Abstract: A preparing method for high-purity levetiracetam, comprising: adjusting the pH of an extracted aqueous layer obtained by dissociating (S)-?-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-methylbenzylamine salt to 5-9; removing water; adding an organic solvent to form a solution and then performing an esterification reaction with ethyl chloroformate or methylchlorofonmate; and carrying out an ammonolysis reaction to obtain the levetiracetam. The method simplifies production process, increases yield, reduces or even avoids the use of triethylamine in the esterification process, and reduces the emission of a great amount of three wastes.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to delta-like protein 3 (DLL3). The antibodies of the present technology are useful in methods for detecting and treating a DLL3-associated cancer in a subject in need thereof.

Abstract: A system and method of detecting a sobriety of a subject utilizing a mobile device. The mobile device includes a processor and a memory storing historical data including movements indicating a drunk state, movements indicating a sober state, or a combination of both. The mobile device further includes a user interface, a recorder operable to capture a recording, and an accelerometer operable to generate acceleration values of movements of the recording. When the mobile device captures the recording of a subject performing movements, the processor compares the data on the memory with the acceleration values of the movements of the subject and produces an indication of either a drunk state of the subject or a sober state of the subject on the user interface.

Abstract: A system and method of detecting a sobriety of a subject utilizing a mobile device. The mobile device includes a processor and a memory storing historical data including movements indicating a drunk state, movements indicating a sober state, or a combination of both. The mobile device further includes a user interface, a recorder operable to capture a recording, and an accelerometer operable to generate acceleration values of movements of the recording. When the mobile device captures the recording of a subject performing movements, the processor compares the data on the memory with the acceleration values of the movements of the subject and produces an indication of either a drunk state of the subject or a sober state of the subject on the user interface.

Abstract: A preparing method for high-purity levetiracetam, comprising: adjusting the pH of an extracted aqueous layer obtained by dissociating (S)-?-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-methylbenzylamine salt to 5-9; removing water; adding an organic solvent to form a solution and then performing an esterification reaction with ethyl chloroformate or methylchlorofonmate; and carrying out an ammonolysis reaction to obtain the levetiracetam. The method simplifies production process, increases yield, reduces or even avoids the use of triethylamine in the esterification process, and reduces the emission of a great amount of three wastes.