Patents by Inventor Xinlei Chen

Xinlei Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11498897
    Abstract: A preparing method for high-purity levetiracetam, comprising: adjusting the pH of an extracted aqueous layer obtained by dissociating (S)-?-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-methylbenzylamine salt to 5-9; removing water; adding an organic solvent to form a solution and then performing an esterification reaction with ethyl chloroformate or methylchlorofonmate; and carrying out an ammonolysis reaction to obtain the levetiracetam. The method simplifies production process, increases yield, reduces or even avoids the use of triethylamine in the esterification process, and reduces the emission of a great amount of three wastes.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: November 15, 2022
    Assignees: Zhejiang Huahai Pharmaceutical Co., Ltd., Zhejiang Huahai Tiancheng Pharmaceutical Co., Ltd., Zhejiang Huahai Zhicheng Pharmaceutical Co., Ltd.
    Inventors: Xinlei Chen, Zhicheng Hu, Liang Zheng, Peng Dong
  • Publication number: 20220348648
    Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to delta-like protein 3 (DLL3). The antibodies of the present technology are useful in methods for detecting and treating a DLL3-associated cancer in a subject in need thereof.
    Type: Application
    Filed: July 8, 2020
    Publication date: November 3, 2022
    Inventors: John T. POIRIER, Charles RUDIN, Jason LEWIS, Abdul KHAN, David ANDREW, Xinlei CHEN, Ivo LORENZ
  • Patent number: 11096625
    Abstract: A system and method of detecting a sobriety of a subject utilizing a mobile device. The mobile device includes a processor and a memory storing historical data including movements indicating a drunk state, movements indicating a sober state, or a combination of both. The mobile device further includes a user interface, a recorder operable to capture a recording, and an accelerometer operable to generate acceleration values of movements of the recording. When the mobile device captures the recording of a subject performing movements, the processor compares the data on the memory with the acceleration values of the movements of the subject and produces an indication of either a drunk state of the subject or a sober state of the subject on the user interface.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: August 24, 2021
    Inventors: Deeptaanshu Kumar, Ajmal Thanikkal, Prithvi Krishnamurthy, Pei Zhang, Xinlei Chen
  • Publication number: 20200253549
    Abstract: A system and method of detecting a sobriety of a subject utilizing a mobile device. The mobile device includes a processor and a memory storing historical data including movements indicating a drunk state, movements indicating a sober state, or a combination of both. The mobile device further includes a user interface, a recorder operable to capture a recording, and an accelerometer operable to generate acceleration values of movements of the recording. When the mobile device captures the recording of a subject performing movements, the processor compares the data on the memory with the acceleration values of the movements of the subject and produces an indication of either a drunk state of the subject or a sober state of the subject on the user interface.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 13, 2020
    Inventors: Deeptaanshu Kumar, Ajmal Thanikkal, Prithvi Krishnamurthy, Pei Zhang, Xinlei Chen
  • Publication number: 20200172479
    Abstract: A preparing method for high-purity levetiracetam, comprising: adjusting the pH of an extracted aqueous layer obtained by dissociating (S)-?-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-methylbenzylamine salt to 5-9; removing water; adding an organic solvent to form a solution and then performing an esterification reaction with ethyl chloroformate or methylchlorofonmate; and carrying out an ammonolysis reaction to obtain the levetiracetam. The method simplifies production process, increases yield, reduces or even avoids the use of triethylamine in the esterification process, and reduces the emission of a great amount of three wastes.
    Type: Application
    Filed: August 9, 2018
    Publication date: June 4, 2020
    Inventors: Xinlei Chen, Zhicheng Hu, Liang Zheng, Peng Dong