Patents by Inventor Xinlei Chen

Xinlei Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240368269
    Abstract: The presently disclosed subject matter provides antibodies or antigen-binding fragments thereof that bind to DLL3 and methods of using such antibodies or antigen-binding fragments thereof same.
    Type: Application
    Filed: February 28, 2024
    Publication date: November 7, 2024
    Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER, SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC.
    Inventors: John T. Poirier, Charles Rudin, Jason Lewis, Abdul Khan, David Andrew, Xinlei Chen, Ivo C. Lorenz, Kathryn M. Tully, Salomon Tendler
  • Publication number: 20240255462
    Abstract: A portable device for detection of cerebrospinal fluid (CSF) in a sample. The device may comprise a substrate and a sensor disposed on the substrate, the sensor comprising a sensing area. The sensor further comprises an aptamer solution comprising an aptamer sequence functionalized by a redox agent to be sensitive to the CSF biomarker and functionalized to attach to the sensor. The sensor may be configured to be sensitive to a CSF biomarker. The device may further comprise an electrochemical detection component operatively coupled to the sensor. When a sample containing an amount of the CSF biomarker is disposed on the sensing area of the sensor, the electrode may generate a detection signal to be transmitted to the electrochemical detection component. The electrochemical detection component may transmit the detection signal to the computing device.
    Type: Application
    Filed: March 11, 2024
    Publication date: August 1, 2024
    Inventors: Edward C. Kuan, Michelle Khine, Andrej Luptak, Arash Abiri, Julia A. Zakashansky, Xinlei Chen
  • Publication number: 20240251611
    Abstract: A display substrate, a preparing method therefor, and a display apparatus are disclosed. The display substrate includes a display region (100), the display region (100) includes a plurality of sub-pixels, at least one sub-pixel includes a circuit unit disposed on the base substrate (101), the circuit unit at least includes a pixel drive circuit and a data signal line (60), the pixel drive circuit is connected with the data signal line (60); the base substrate (101) includes a base substrate conductive layer disposed between the first flexible layer (101A) and the second flexible layer (101C), the base substrate conductive layer at least includes a data fan-out line (70), and the data signal line (60) is connected with the data fan-out line (70) through a lapping via (DV1).
    Type: Application
    Filed: February 25, 2022
    Publication date: July 25, 2024
    Inventors: Xiaoqi DING, Changchang LIU, Xuewei TIAN, Ke LIU, Fei FANG, Liqiang CHEN, Ling SHI, Shuo LI, Guoyi CUI, Xinlei YANG
  • Publication number: 20240216557
    Abstract: The presently disclosed subject matter provides compositions and methods for in vivo diagnosis and treatment of diseases or disorders associated with DLL3. In particular, the presently disclosed subject matter provides novel anti-DLL3 antibodies-TCO conjugates, which can form a radioimmunoconjugate with a radioligand comprising a radioactive isotope.
    Type: Application
    Filed: February 28, 2024
    Publication date: July 4, 2024
    Applicants: Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute for Cancer Research, Memorial Hospital for Cancer and Allied Diseases, Tri-Institutional Therapeutics Discovery Institute, Inc.
    Inventors: John T. POIRIER, Charles Rudin, Jason Lewis, Abdul Khan, David Andrew, Xinlei Chen, Ivo C. Lorenz, Kathryn M. Tully, Salomon Tendler
  • Publication number: 20240197398
    Abstract: A cooling sleeve includes an inner tube within which a bar-shaped or tubular object is placed to be cooled, and an outer tube within which the inner tube is located. The outer wall surface of the bar-shaped or tubular object contacts with the inner wall surface of the inner tube to form first contact portions, and axial gaps from the adjacent first contact portions form first circulation channels, and the inner wall surface of the outer tube contacts with the outer wall surface of the inner tube to form second contact portions, and axial gaps from the adjacent second contact portions form second circulation channels. Proximal ends of the first and second circulation channels are connected with each other inside the proximal end of the outer tube via a forming cavity, and distal ends of the first and second circulation channels are independently connected externally.
    Type: Application
    Filed: April 26, 2022
    Publication date: June 20, 2024
    Inventors: HUIJIE JIN, PENG CAO, LIANGDAO XIA, XINLEI CHEN, XIANGLIANG LIAO
  • Publication number: 20240115721
    Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.
    Type: Application
    Filed: January 13, 2022
    Publication date: April 11, 2024
    Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: John T. POIRIER, Charles RUDIN, Jason LEWIS, Abdul KHAN, David ANDREW, Xinlei CHEN, Ivo LORENZ, Hironori MATSUNAGA
  • Publication number: 20240115720
    Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.
    Type: Application
    Filed: January 13, 2022
    Publication date: April 11, 2024
    Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: John T. POIRIER, Charles RUDIN, Jason LEWIS, Abdul KHAN, David ANDREW, Xinlei CHEN, Ivo LORENZ, Hironori MATSUNAGA
  • Publication number: 20240096072
    Abstract: In particular embodiments, a computing system may access a plurality of images for pre-training a first machine-learning model that includes an encoder and a decoder. Using each image, the system may pre-train the model by dividing the image into a set a patches, selecting a first subset of the patches to be visible and a second subset of the patches to be masked during the pre-training, processing, using the encoder, the first subset of patches to generate corresponding first latent representations, processing, using the decoder, the first latent representations corresponding to the first subset of patches and mask tokens corresponding to the second subset of patches to generate reconstructed patches corresponding to the second subset of patches, the reconstructed patches and the first subset of patches being used to generate a reconstructed image, and updating the model based on comparisons between the image and the reconstructed image.
    Type: Application
    Filed: July 27, 2022
    Publication date: March 21, 2024
    Inventors: Kaiming He, Piotr Dollar, Ross Girshick, Saining Xie, Xinlei Chen, Yanghao Li
  • Patent number: 11498897
    Abstract: A preparing method for high-purity levetiracetam, comprising: adjusting the pH of an extracted aqueous layer obtained by dissociating (S)-?-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-methylbenzylamine salt to 5-9; removing water; adding an organic solvent to form a solution and then performing an esterification reaction with ethyl chloroformate or methylchlorofonmate; and carrying out an ammonolysis reaction to obtain the levetiracetam. The method simplifies production process, increases yield, reduces or even avoids the use of triethylamine in the esterification process, and reduces the emission of a great amount of three wastes.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: November 15, 2022
    Assignees: Zhejiang Huahai Pharmaceutical Co., Ltd., Zhejiang Huahai Tiancheng Pharmaceutical Co., Ltd., Zhejiang Huahai Zhicheng Pharmaceutical Co., Ltd.
    Inventors: Xinlei Chen, Zhicheng Hu, Liang Zheng, Peng Dong
  • Publication number: 20220348648
    Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to delta-like protein 3 (DLL3). The antibodies of the present technology are useful in methods for detecting and treating a DLL3-associated cancer in a subject in need thereof.
    Type: Application
    Filed: July 8, 2020
    Publication date: November 3, 2022
    Inventors: John T. POIRIER, Charles RUDIN, Jason LEWIS, Abdul KHAN, David ANDREW, Xinlei CHEN, Ivo LORENZ
  • Patent number: 11096625
    Abstract: A system and method of detecting a sobriety of a subject utilizing a mobile device. The mobile device includes a processor and a memory storing historical data including movements indicating a drunk state, movements indicating a sober state, or a combination of both. The mobile device further includes a user interface, a recorder operable to capture a recording, and an accelerometer operable to generate acceleration values of movements of the recording. When the mobile device captures the recording of a subject performing movements, the processor compares the data on the memory with the acceleration values of the movements of the subject and produces an indication of either a drunk state of the subject or a sober state of the subject on the user interface.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: August 24, 2021
    Inventors: Deeptaanshu Kumar, Ajmal Thanikkal, Prithvi Krishnamurthy, Pei Zhang, Xinlei Chen
  • Publication number: 20200253549
    Abstract: A system and method of detecting a sobriety of a subject utilizing a mobile device. The mobile device includes a processor and a memory storing historical data including movements indicating a drunk state, movements indicating a sober state, or a combination of both. The mobile device further includes a user interface, a recorder operable to capture a recording, and an accelerometer operable to generate acceleration values of movements of the recording. When the mobile device captures the recording of a subject performing movements, the processor compares the data on the memory with the acceleration values of the movements of the subject and produces an indication of either a drunk state of the subject or a sober state of the subject on the user interface.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 13, 2020
    Inventors: Deeptaanshu Kumar, Ajmal Thanikkal, Prithvi Krishnamurthy, Pei Zhang, Xinlei Chen
  • Publication number: 20200172479
    Abstract: A preparing method for high-purity levetiracetam, comprising: adjusting the pH of an extracted aqueous layer obtained by dissociating (S)-?-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-methylbenzylamine salt to 5-9; removing water; adding an organic solvent to form a solution and then performing an esterification reaction with ethyl chloroformate or methylchlorofonmate; and carrying out an ammonolysis reaction to obtain the levetiracetam. The method simplifies production process, increases yield, reduces or even avoids the use of triethylamine in the esterification process, and reduces the emission of a great amount of three wastes.
    Type: Application
    Filed: August 9, 2018
    Publication date: June 4, 2020
    Inventors: Xinlei Chen, Zhicheng Hu, Liang Zheng, Peng Dong