Abstract: The disclosed invention relates to methods and transgenic non-human mammals comprising a full length human VIPR2 genomic region integrated into a genome of the mammal. According to a further embodiment the mammal is a mouse. The disclosed invention further relates to transgenic cells from the transgenic non-human mammal. The disclosed invention further relates to therapeutics and methods of treating Schizophrenia in a human comprising administering a therapeutic, where the therapeutic contains one of a pharmacologically effective amount of a hVIPR2 antagonist, and a CRISPR/Cas9 formulation. The disclosed invention further relates to materials and methods of determining efficacy of an antipsychotic therapeutic in treating a condition comprising administering to the transgenic non-human mammal.

Abstract: The embodiments of the present disclosure provide a display substrate, a display panel, and a display device. The display substrate includes: a first base substrate, wherein a plurality of sub-pixel regions arranged in an array are provided on the first base substrate; and a reflective layer provided on one side of the first base substrate, wherein a surface of the reflective layer away from the first base substrate is formed to include a plurality of first bumps and a plurality of second bumps, and the first bump has a size greater than that of the second bump.

Abstract: The present disclosure provides a method, a device, a storage medium and a program product for carbon trading.

Abstract: A method for gene editing in a vertebrate brain comprising: intravascular administration of a brain penetrable viral vector including a target sequence in a genomic locus of interest and a CRISPR enzyme; genomic integration via Non-Homologues End Joining (NHEJ) in post-mitotic neurons; and editing a monopartite cell-type specific gene via NHEJ knock-in a sgRNA flanked by self-cleaving ribozymes into 3?UTR to use an endogenous promoter for sgRNA expression.

Abstract: A method and apparatus for processing carbon emission reduction data, and a computer readable storage medium. The method includes: determining a target smart contract matching an attribute of an object carrying out a carbon emission reduction activity (210); determining a carbon emission reduction equivalent corresponding to the object based on the target smart contract and carbon activity data corresponding to the carbon emission reduction activity (220); and sending the carbon emission reduction equivalent to a node of a blockchain platform to store same in a first account associated with a corporate user on the blockchain platform (230). The solution can be used to effectively and accurately calculate a carbon emission or an emission reduction of a user.

Abstract: Provided are a system and a method for assembling a double-deck vehicle body. The system includes a vehicle body chassis support and an upper floor support. The vehicle body chassis support includes a crossbeam, end supports, and an intermediate support, where the end supports are arranged separately at two ends of the crossbeam, the intermediate support is arranged at the middle of the crossbeam, a height of the end supports is greater than a height of the intermediate support, an upper surface of the end supports and an upper surface of the intermediate support are configured to be closely fitted to a lower surface of a vehicle body chassis; and the upper floor support is detachably arranged on a vehicle body chassis for supporting an upper floor of the vehicle body.

Abstract: The disclosed invention relates to methods and transgenic non-human mammals comprising a full length human VIPR2 genomic region integrated into a genome of the mammal. According to a further embodiment the mammal is a mouse. The disclosed invention further relates to transgenic cells from the transgenic non-human mammal. The disclosed invention further relates to therapeutics and methods of treating Schizophrenia in a human comprising administering a therapeutic, where the therapeutic contains one of a pharmacologically effective amount of a hVIPR2 antagonist, and a CRISPR/Cas9 formulation. The disclosed invention further relates to materials and methods of determining efficacy of an antipsychotic therapeutic in treating a condition comprising administering to the transgenic non-human mammal.

Abstract: A genetically modified non-human animal comprising a genome containing an endogenous non-human ACE2 locus genetically modified to encode a complete human ACE2 gene. According to a further embodiment the genome is genetically modified to encode a second, a third, and a fourth complete human ACE2 gene, the human ACE2 gene is at least 85 percent identical to SEQ ID No: 1, the animal of is a mouse, the human ACE2 gene encodes six protein variants, an endogenous Tmprss2 gene is unmodified, a LoxP gene flanks each of a 5? and a 3? end of a nucleic acid sequence of the human ACE2 gene, and the human ACE2 gene is expressed in a lung, kidney, spleen, stomach, liver, intestine, heart, and skeletal muscle of the animal, and a cortex, striatum, middle brain, hippocampus, olfactory bulb, and cerebellum of a brain of the animal.

Abstract: The present disclosure provides a method, a device, a storage medium and a program product for carbon trading.

Abstract: Methods, devices, block chain nodes, computer readable media and a system for carbon recording and trading based on a block chain. A method for carbon recording and trading based on a block chain includes: obtaining data related to carbon behaviors of a plurality of objects; converting the data related to the carbon behaviors of the plurality of objects to corresponding carbon data of the plurality of objects, respectively; transmitting the carbon data to a block chain platform for storage; performing, based on the carbon data, a carbon trading between two objects in the plurality of objects or one object in the plurality of objects and a third party object not belonging to the plurality of objects; and distributing the carbon trading to the block chain platform as a block chain transaction.

Abstract: Provided are a system and a method for assembling a double-deck vehicle body. The system includes a vehicle body chassis support and an upper floor support. The vehicle body chassis support includes a crossbeam, end supports, and an intermediate support, where the end supports are arranged separately at two ends of the crossbeam, the intermediate support is arranged at the middle of the crossbeam, a height of the end supports is greater than a height of the intermediate support, an upper surface of the end supports and an upper surface of the intermediate support are configured to be closely fitted to a lower surface of a vehicle body chassis; and the upper floor support is detachably arranged on a vehicle body chassis for supporting an upper floor of the vehicle body.