Patents by Inventor Xinliang Zhao

Xinliang Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted pre-mRNA/mRNA modification and gene regulation
    Patent number: 9238813
    Abstract: Methods for affecting mRNA expression or translation through the modification of pre-mRNA or mRNA transcripts are described. In one embodiment of the methods of the present invention, the branch point adenosine of a pre-mRNA transcript is 2?-0-methylated to block splicing and subsequent expression of the protein encoded by the transcript. In another embodiment, a uridine residue in a nonsense stop codon may be modified to pseudouridine, causing the translation machinery to read through the nonsense stop codon and translate a full length protein.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: January 19, 2016
    Assignee: University of Rochester
    Inventors: Yi-Tao Yu, Xinliang Zhao
  • Targeted pre-mRNA/mRNA modification and gene regulation
    Publication number: 20140186300
    Abstract: Methods for affecting mRNA expression or translation through the modification of pre-mRNA or mRNA transcripts are described. In one embodiment of the methods of the present invention, the branch point adenosine of a pre-mRNA transcript is 2?-0-methylated to block splicing and subsequent expression of the protein encoded by the transcript. In another embodiment, a uridine residue in a nonsense stop codon may be modified to pseudouridine, causing the translation machinery to read through the nonsense stop codon and translate a full length protein.
    Type: Application
    Filed: October 17, 2013
    Publication date: July 3, 2014
    Applicant: University of Rochester
    Inventors: Yi-Tao YU, Xinliang Zhao
  • Nonsense suppression and genetic codon alteration by targeted modification
    Patent number: 8603457
    Abstract: Methods for affecting mRNA expression or translation through the modification of pre-mRNA or mRNA transcripts are described. In one embodiment of the methods of the present invention, the branch point adenosine of a pre-mRNA transcript is 2?-O-methylated to block splicing and subsequent expression of the protein encoded by the transcript. In another embodiment, a uridine residue in a nonsense stop codon may be modified to pseudouridine, causing the translation machinery to read through the nonsense stop codon and translate a full length protein.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: December 10, 2013
    Assignee: University of Rochester
    Inventors: Yi-Tao Yu, Xinliang Zhao
  • Targeted pre-mRNA/mRNA modification and gene regulation
    Publication number: 20070141030
    Abstract: Methods for affecting mRNA expression or translation through the modification of pre-mRNA or mRNA transcripts are described. In one embodiment of the methods of the present invention, the branch point adenosine of a pre-mRNA transcript is 2?-O-methylated to block splicing and subsequent expression of the protein encoded by the transcript. In another embodiment, a uridine residue in a nonsense stop codon may be modified to pseudouridine, causing the translation machinery to read through the nonsense stop codon and translate a full length protein.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 21, 2007
    Inventors: Yi-Tao Yu, Xinliang Zhao