Abstract: Disclosed are systems and techniques for determining an acoustic biomarker. For example, a precordial sound recording that includes at least a first sound component corresponding to a heart and a second sound component corresponding to a left ventricular assist device (LVAD) can be obtained. At least a portion of the second sound component corresponding to the LVAD can be filtered from the precordial sound recording to yield a filtered precordial sound recording. Based on the filtered precordial sound recording, at least one acoustic biomarker can be determined.

Abstract: Disclosed are systems and techniques for determining an acoustic biomarker. For example, a precordial sound recording that includes at least a first sound component corresponding to a heart and a second sound component corresponding to a left ventricular assist device (LVAD) can be obtained. At least a portion of the second sound component corresponding to the LVAD can be filtered from the precordial sound recording to yield a filtered precordial sound recording. Based on the filtered precordial sound recording, at least one acoustic biomarker can be determined.

Abstract: An optical imaging method based on mapping of a layered structure. The specific spatial distribution and optical properties of materials in each layer are fully taken into account so that optical information of each corresponding layer can be separated out, wherein the optical information comprises absorption and scattering coefficients of each layer. The method is applied to biological system detection to obtain physiological parameter information of each layer of tissue, wherein the physiological parameter information comprises the content of oxyhemoglobin, the content of deoxyhemoglobin the content of melanin, and epidermal thickness. The method in combination with SFDI technology is applied to forearm reactive hyperemia experiments and skin mole examinations yielding positive results.

Abstract: An optical imaging method based on mapping of a layered structure. The specific spatial distribution and optical properties of materials in each layer are fully taken into account so that optical information of each corresponding layer can be separated out, wherein the optical information comprises absorption and scattering coefficients of each layer. The method is applied to biological system detection to obtain physiological parameter information of each layer of tissue, wherein the physiological parameter information comprises the content of oxyhemoglobin, the content of deoxyhemoglobin the content of melanin, and epidermal thickness. The method in combination with SFDI technology is applied to forearm reactive hyperemia experiments and skin mole examinations yielding positive results.