Abstract: A peptide of formula (I), i.e., R1—Wm-AA1-AA2-AA3-AA4-Trp-AA5-Xn—Yp—Zq—R2, a stereoisomer thereof, a mixture of stereoisomers thereof, a salt thereof, or a composition thereof, and a use thereof in the preparation of a composition for inhibiting ROCK activity, preventing aging or photoaging, and implementing anti-aging repair and moisturization.

Abstract: Disclosed are a peptide having formula (I), i.e. R1-X1-X2-X3-Leu-Tyr-X4-X5-R2, or a stereoisomer of the peptide, or a mixture of the stereoisomer of the peptide, or a salt of the peptide, or a mixture thereof, and the use thereof in the preparation of a composition for resisting aging or photoaging, anti-aging repair, soothing and moisturizing.

Abstract: The present application provides a polypeptide and a cosmetic composition or pharmaceutical composition and use thereof. The polypeptide has the following general formula: R1—X1—X2—X3—X4—X5—X6—X7—X8—R2. The present application relates to a peptide, stereoisomers thereof, a mixture of the stereoisomers, or a cosmetically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, or a cosmetic composition or a pharmaceutical composition thereof, and a use thereof in the preparation of the cosmetic composition or pharmaceutical composition for improving skin aging or photoaging, and treating or caring for a condition, a disorder or a disease caused by muscle contraction.

Abstract: A peptide as represented by general formula (I), a stereoisomer thereof, a mixture of the stereoisomer, or a cosmetically acceptable salt or pharmaceutically acceptable salt thereof, or a cosmetic composition or pharmaceutical composition thereof, and an application thereof for treatment or care of a disorder, an illness, or a disease of the skin or mucosa.

Abstract: The present invention relates to a hexapeptide, a cosmetic composition or a pharmaceutical composition thereof, and a use thereof, the peptide has the following general formula: R1-Phe-Phe-Trp-Phe-X1-X2-R2. The peptide of the present invention, a stereoisomer thereof, or a mixture of stereoisomers thereof, or a cosmetically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, or their cosmetic compositions or pharmaceutical compositions, and their uses in the preparation of a cosmetic composition or a pharmaceutical composition for anti-inflammation and skin barrier repair.

Abstract: A peptide derivative and a cosmetic composition or pharmaceutical composition and use thereof. The peptide derivative has the following general formula: R1—Pro-Lys-Glu-Lys-R2. The peptide derivative is obtained by means of covalent binding of niacin, tranexamic acid or kojic acid with a peptide, has the effects of relieving skin inflammation reaction and inhibiting melanin generation, and can be used in the fields of cosmetics or medicines for anti-inflammation as well as whitening and freckle-removing of skin, especially for improving post-inflammation hyperpigmentation.

Abstract: Provided are a peptide derivative and a cosmetic composition or pharmaceutical composition and use thereof. The peptide derivative has a general formula as follows: R1-Gly-Pro-Gln-Gly-Pro-Gln-R2. The peptide derivative is obtained by covalently binding caffeic acid and gallic acid to peptide, respectively; and compared with single caffeic acid, gallic acid and single polypeptide, the peptide derivative has excellent skin photoaging and anti-oxidation effects, and can be applied to the fields of cosmetics, medicines, and the like.

Abstract: The present disclosure provides a pH and oxygen dual-sensitive magnetic resonance imaging contrast agent and a preparation method thereof, which is a dual-modal nanoparticle contrast agent with 19F signal and CEST dual signal (19F-CEST), a CEST contrast agent that is dual-sensitive to pH and oxygen. The preparation method comprises: mixing a variety of phospholipid surfactants and cholesterol well to obtain a blend of phospholipid surfactants, which is dissolved in chloroform or a mixed solvent of chloroform and methanol, evaporated to dryness with a rotary evaporator and dried overnight in a vacuum oven at 40° C. after adding rhodamine, finally, it is dispersed in water containing glycerin by mechanical dispersion or ultrasonic vibration to obtain a lipid modifier; mixing perfluorocarbon, the lipid modifier obtained in step (1), glycerin, and water and ultrasonically mixing well with a probe, and extruding with an extruder to prepare a perfluorocarbon nanoemulsion.

Abstract: Disclosed is a molecular imaging method for evaluating liver regeneration ability after ALPPS. The method includes steps of: 1) preparing a VX2 rabbit liver cancer model; 2) performing ALPPS for the VX2 rabbit liver cancer model; 3) synthesizing 18F-Fluoromethylcholine (18F-Methylcholine, 18F-FCH); 4) PET/CT imaging and data processing for 18F-FCH. The disclosure is the first to propose the use of 18F-FCH PET/CT to monitor the proliferative capacity of residual liver, and further indirectly reflect the increased ability of cell membrane synthesis on the basis that 18F-FCH has higher choline metabolism in residual liver tissue, so that the liver regeneration ability after ALPPS is evaluated by the molecular imaging method, thereby providing important new ideas for the clinical selection of ALPPS to choose the best time for second-stage surgery.