Abstract: A digital twin-based intelligent slope monitoring method, system, and storage medium are provided. The method includes obtaining point cloud data of a surface of a slope, creating a digital twin model; dividing the digital twin model to generate a plurality of first grids, calculating a displacement change value of each first grid during a target duration; defining the first grid with a displacement change value greater than a first threshold as a first region, dividing the target duration into a plurality of first durations with different lengths; setting a plurality of rainfall patterns, determining an optimal pattern for each first duration, calculating representative rainfall, constructing a prediction model, predicting representative rainfall for a future duration based on the optimal pattern and the representative rainfall of the first duration; generating a safety factor of the first region during the future duration based on the representative rainfall and a pore water pressure.

Abstract: This disclosure is directed to a pharmaceutical composition for treating or preventing a disease. The pharmaceutical composition can comprise a polymer-drug nanoaggregate having a polymer and at least one bioactive agent that can comprise STING polypeptide, a nucleic acid encoding said STING polypeptide, a STING inhibitor, a STING activator, a STING agonist, a STING antagonist, a STING modulating molecule, or a combination thereof. The pharmaceutical composition can be a vaccine or an adjuvant for a vaccine. This disclosure is also directed to a method for treating or preventing a disease using the pharmaceutical composition. The disease can include infectious diseases caused by viruses or other pathogens, for example, influenza, rabies, or respiratory illnesses such as severe acute respiratory syndrome (SARS) caused by coronaviruses, such as MERS-CoV, SARS-CoV, and Coronavirus Disease 2019 (COVID-19) caused by the virus SARS-CoV-2 and its variants.

Abstract: Provided herein are a series of compounds and their use as an adjuvant. Provided herein are the compounds, a composition comprising the compounds, and the use thereof. These compounds can be used as an adjuvant for a vaccine, and compared to the conventional aluminum adjuvant, the compounds can significantly improve the cellular and humoral immune responses to a vaccine. The compounds as an adjuvant can increase a broad-spectrum protection against various corona viruses such as SARS virus, influenza viruses, and HIV viruses, and significantly enhance persistence of immunoprotection of vaccines.