Patents by Inventor Xinming Du

Xinming Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDOLONE DERIVATIVE HAVING IRAK4 INHIBITORY ACTIVITY, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20260217704
    Abstract: The present application relates to an indolone derivative having an IRAK4 inhibitory activity as represented by formula (I), a preparation method therefor and the use thereof, and further relates to a compound capable of inhibiting and degrading the IRAK4 protein and a pharmaceutical composition comprising the indolone derivative or the compound capable of inhibiting and degrading the IRAK4 protein.
    Type: Application
    Filed: January 11, 2024
    Publication date: July 30, 2026
    Applicant: DOVETREE MEDICINES UNUS, INC.
    Inventors: XinMing DU, LiFei DU, ZhaoQiang CHEN, JunJun MA, ShaoHui WANG, Bin CHEN, PeiYu ZHANG
  • NOVEL IRAK4 INHIBITOR AND COMPOUND FOR INHIBITING AND DEGRADING IRAK4 PROTEIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20260200944
    Abstract: The present application relates to a novel IRAK4 inhibitor of formula (I) and a compound for inhibiting and degrading IRAK4 protein, a preparation method therefor and use thereof, and also relates to a pharmaceutical composition comprising the IRAK4 inhibitor or the compound for inhibiting and degrading IRAK4 protein.
    Type: Application
    Filed: November 29, 2023
    Publication date: July 16, 2026
    Applicant: DOVETREE MEDICINES UNUS, INC.
    Inventors: XinMing DU, JunJun MA, ZhaoQiang CHEN, LiFei DU, ShaoHui WANG, Bin CHEN, PeiYu ZHANG
  • CRBN LIGAND, PREPARATION METHOD THEREFOR, AND APPLICATION
    Publication number: 20260191970
    Abstract: Provided are a compound or an enantiomer, diastereoisomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, or metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound, or prodrug thereof, as well as an application thereof in the treatment of a CRBN-mediated disease or disorder.
    Type: Application
    Filed: September 30, 2025
    Publication date: July 9, 2026
    Applicant: Shenzhen Zhongge Biological Technology Co., Ltd.
    Inventors: Junjun Ma, Fanyang Ji, Xinming Du, Zhaoqiang Chen, Lifei Du, Shaohui Wang, Bin Chen, Peiyu Zhang
  • COMPOUND FOR INHIBITING IRAK4 ACTIVITY AND USE THEREOF
    Publication number: 20260028337
    Abstract: The present application relates to a compound for inhibiting IRAK4 activity and a use thereof, and specifically provides a compound as represented by formula A, or an enantiomer, a diastereoisomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a nitrogen oxide, a metabolite or a pharmaceutically acceptable salt, an ester, a solvate, a hydrate, an isotope-labeled compound (preferably a deuterated substance), or a prodrug thereof,
    Type: Application
    Filed: July 21, 2023
    Publication date: January 29, 2026
    Inventors: Xinming DU, He XU, Lifei DU, Zhaoqiang CHEN, Yuanpeng LI, Yutao MI, Mengyang QU, Jilong JIA, Junjun MA, Junjie ZOU, Rongfeng ZOU, Xiaoming WEN, Shaohui WANG, Bin CHEN, Peiyu ZHANG
  • Acetophenone oxime compound and application thereof
    Patent number: 12479794
    Abstract: Disclosed are an acetophenone oxime compound and a preparation method therefor, and specifically disclosed are a compound as shown in formula (II) and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: November 25, 2025
    Assignee: Medshine Discovery Inc.
    Inventors: Lingyun Wu, Lele Zhao, Xinming Du, Xu You, Shuhui Chen
  • SMALL MOLECULE INHIBITOR FOR CATHEPSIN C AND MEDICINAL USE THEREOF
    Publication number: 20240083888
    Abstract: The present disclosure relates to a small molecule inhibitor of cathepsin C and the medicinal use thereof. Specifically, provided in the present disclosure are an amide nitrile compound represented by formula VI, a pharmaceutical composition containing the compound, and the use thereof in the inhibition of cathepsin C.
    Type: Application
    Filed: December 3, 2021
    Publication date: March 14, 2024
    Inventors: Xin Hao, Shuyi Gong, Defeng Shen, Xinming Du
  • ACETOPHENONE OXIME COMPOUND AND APPLICATION THEREOF
    Publication number: 20230295076
    Abstract: Disclosed are an acetophenone oxime compound and a preparation method therefor, and specifically disclosed are a compound as shown in formula (II) and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 16, 2021
    Publication date: September 21, 2023
    Inventors: Lingyun Wu, Lele Zhao, Xinming Du, Xu You, Shuhui Chen