Patents by Inventor Xinming Qian
Xinming Qian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240018309Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: ApplicationFiled: September 12, 2023Publication date: January 18, 2024Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 11802182Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: May 12, 2022Date of Patent: October 31, 2023Assignee: Alcon Inc.Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Publication number: 20230158760Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a watersoluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: November 21, 2022Publication date: May 25, 2023Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 11534994Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: GrantFiled: January 11, 2021Date of Patent: December 27, 2022Assignee: Alcon Inc.Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Publication number: 20220275154Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: ApplicationFiled: May 12, 2022Publication date: September 1, 2022Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 11365288Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: September 30, 2020Date of Patent: June 21, 2022Assignee: Alcon Inc.Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 11346982Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: September 30, 2020Date of Patent: May 31, 2022Assignee: Alcon Inc.Inventors: Daqing Wu, Junhao Ge, Steve Yun Zhang, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 11001647Abstract: The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.Type: GrantFiled: February 20, 2019Date of Patent: May 11, 2021Assignee: Alcon Inc.Inventors: Frank Chang, Troy Vernon Holland, Xinming Qian, Robert Scott, Joseph Michael Lindacher, Uwe Haken
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Publication number: 20210130648Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: January 11, 2021Publication date: May 6, 2021Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 10920102Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: GrantFiled: December 19, 2019Date of Patent: February 16, 2021Assignee: Alcon Inc.Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Publication number: 20210009762Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: ApplicationFiled: September 30, 2020Publication date: January 14, 2021Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Publication number: 20210011197Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: ApplicationFiled: September 30, 2020Publication date: January 14, 2021Inventors: Daqing Wu, Junhao Ge, Steve Yun Zhang, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 10875967Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: June 6, 2018Date of Patent: December 29, 2020Assignee: Alcon Inc.Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 10866344Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: June 6, 2018Date of Patent: December 15, 2020Assignee: Alcon Inc.Inventors: Daqing Wu, Junhao Ge, Steve Yun Zhang, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 10843422Abstract: The present invention generally relates to a method for producing inherently wettable silicone hydrogel contact lenses with a robusteness of lens shape and having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus.Type: GrantFiled: June 6, 2018Date of Patent: November 24, 2020Assignee: Alcon, Inc.Inventors: Daqing Wu, Steve Yun Zhang, Xinming Qian, Zach Munoz, Frank Chang, Wei Liang, Ying Zheng, Richard Charles Breitkopf, Matthew D. Nelson, Augustine Twum Kumi
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Publication number: 20200157378Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: December 19, 2019Publication date: May 21, 2020Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 10598825Abstract: The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.Type: GrantFiled: April 30, 2019Date of Patent: March 24, 2020Assignee: Alcon Inc.Inventors: Xinming Qian, Frank Chang, Yasuo Matsuzawa, Venkat Shankar
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Patent number: 10563090Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: GrantFiled: April 29, 2019Date of Patent: February 18, 2020Assignee: Novartis AGInventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 10449740Abstract: The present invention generally relates to a method for producing silicone hydrogel contact lenses having a stable lubricious coating thereon without involving use of organic solvent in post-curing processes.Type: GrantFiled: December 13, 2016Date of Patent: October 22, 2019Assignee: Novartis AGInventors: Xinming Qian, Jared Nelson, Robert Carey Tucker, Steve Yun Zhang, Daqing Wu, Leroy Wainaina Muya, Dharmesh Patel, Zach Munoz, Yongxing Qiu, Chung-Yuan Chiang, Ritu Shrestha, Kelly Kayi Tallau
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Publication number: 20190309188Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: April 29, 2019Publication date: October 10, 2019Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson