Patents by Inventor Xinning Wang

Xinning Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10434194
    Abstract: A PSMA targeted nanobubble includes a membrane that defines at least one internal void, which includes at least one gas, and at least one PSMA ligand coupled or conjugated to the membrane. The membrane includes at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: October 8, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: James R. Basilion, Agata Exner, Xinning Wang, Christopher Hernandez
  • Patent number: 10363313
    Abstract: Compounds that are PSMA ligands, pharmaceutical compositions comprising these compounds, methods for treating and detecting cancers in a subject, methods for identifying cancer cells in a sample are described herein.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: July 30, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: James Basilion, Xinning Wang, Clemens Burda
  • Publication number: 20190175745
    Abstract: A phthalocyanine compound or targeted conjugate thereof having the formula (I).
    Type: Application
    Filed: February 19, 2019
    Publication date: June 13, 2019
    Inventors: James Basilion, Xinning Wang, Clemens Burda
  • Patent number: 10207005
    Abstract: A phthalocyanine compound or targeted conjugate thereof having the formula (I).
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: February 19, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: James Basilion, Xinning Wang, Clemens Burda
  • Publication number: 20180369385
    Abstract: Compounds that are PSMA ligands, pharmaceutical compositions comprising these compounds, methods for treating and detecting cancers in a subject, methods for identifying cancer cells in a sample are described herein.
    Type: Application
    Filed: February 13, 2018
    Publication date: December 27, 2018
    Inventors: James Basilion, Xinning Wang, Clemens Burda
  • Patent number: 9889199
    Abstract: Compounds that are PSMA ligands, pharmaceutical compositions comprising these compounds, methods for treating and detecting cancers in a subject, methods for identifying cancer cells in a sample are described herein. Prostate-specific membrane antigen (PSMA) is a 120 kDa protein expressed in prostate tissues and was originally identified by reactivity with a monoclonal antibody designated 7EII-C5 (Horoszewicz et al., 1987, Anticancer Res. 7:927-935; U.S. Pat. No. 5,162,504). PSMA is characterized as a type II transmembrane protein sharing sequence identity with the transferrin receptor (Israeli et al., 1994, Cancer Res. 54:1807-1811).
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: February 13, 2018
    Assignee: Case Western Reserve University
    Inventors: James Basilion, Xinning Wang, Clemens Burda
  • Publication number: 20170354748
    Abstract: A PSMA-specific imaging agent comprising a compound according to formula I: are described, wherein S1 is an organic spacer group having from 5 to 30 carbons, A is an amino acid forming a portion of a negatively charged peptide oligomer, n is from 3 to 6, S2 is an organic spacer group having from 5 to 15 carbons, and I is an imaging group, and pharmaceutically acceptable salts thereof. The PSMA-specific imaging agents can be used to image PSMA within a tissue region to guide the treatment of diseases such as prostate cancer.
    Type: Application
    Filed: June 26, 2017
    Publication date: December 14, 2017
    Inventors: Steve Shih-Lin Huang, Warren D. Heston, Xinning Wang
  • Publication number: 20170281789
    Abstract: A phthalocyanine compound or targeted conjugate thereof having the formula (I).
    Type: Application
    Filed: June 21, 2017
    Publication date: October 5, 2017
    Inventors: James Basilion, Xinning Wang, Clemens Burda
  • Patent number: 9713649
    Abstract: A PSMA-specific imaging agent comprising a compound according to formula I: are described, wherein S1 is an organic spacer group having from 5 to 30 carbons, A is an amino acid forming a portion of a negatively charged peptide oligomer, n is from 3 to 6, S2 is an organic spacer group having from 5 to 15 carbons, and I is an imaging group, and pharmaceutically acceptable salts thereof. The PSMA-specific imaging agents can be used to image PSMA within a tissue region to guide the treatment of diseases such as prostate cancer.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: July 25, 2017
    Assignee: The Cleveland Clinic Foundation
    Inventors: Steve Shih-Lin Huang, Warren D. Heston, Xinning Wang
  • Publication number: 20150209453
    Abstract: A PSMA-specific imaging agent comprising a compound according to formula I: are described, wherein S1 is an organic spacer group having from 5 to 30 carbons, A is an amino acid forming a portion of a negatively charged peptide oligomer, n is from 3 to 6, S2 is an organic spacer group having from 5 to 15 carbons, and I is an imaging group, and pharmaceutically acceptable salts thereof. The PSMA-specific imaging agents can be used to image PSMA within a tissue region to guide the treatment of diseases such as prostate cancer.
    Type: Application
    Filed: January 26, 2015
    Publication date: July 30, 2015
    Inventors: Steve Shih-Lin Huang, Warren D. Heston, Xinning Wang
  • Publication number: 20070293467
    Abstract: The present invention provides a stereo-isomer of the demethylcantharidin platinum complex of formula I and use thereof. The stereo-isomer inhibits the growth of cisplatin, carboplatin or oxaliplatin-sensitive and -resistant tumorous cells. The invention also describes a pharmaceutical composition comprising the stereo-isomer of the demethylcantharidin platinum complex and use thereof.
    Type: Application
    Filed: April 8, 2005
    Publication date: December 20, 2007
    Inventors: Yee Ho, Steve Au-Yeung, Kin To, Xinning Wang
  • Patent number: 6721926
    Abstract: A method and apparatus provide a digital circuit including dynamic logic that minimizes circuit-path delay, residue logic, and circuit area. The method and apparatus use a library of circuit cells to produce a digital circuit design using a mapping algorithm. The mapping algorithm firstly determines an arrangement of circuit cells to minimize the delay in the circuit design, secondly determines an arrangement of circuit cells to minimize the residue logic for the circuit design, thirdly determines an arrangement of circuit cells to minimize the circuit area for the circuit design, and then repeats the process for each node in the circuit until the best circuit design is produced in accordance with pre-determined criteria.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: April 13, 2004
    Assignee: Intel Corporation
    Inventors: Xinning Wang, Prashant Sawkar, Barbara Chappell
  • Publication number: 20030145288
    Abstract: A method and apparatus provide a digital circuit including dynamic logic that minimizes circuit-path delay, residue logic, and circuit area. The method and apparatus use a library of circuit cells to produce a digital circuit design using a mapping algorithm. The mapping algorithm firstly determines an arrangement of circuit cells to minimize the delay in the circuit design, secondly determines an arrangement of circuit cells to minimize the residue logic for the circuit design, thirdly determines an arrangement of circuit cells to minimize the circuit area for the circuit design, and then repeats the process for each node in the circuit until the best circuit design is produced in accordance with pre-determined criteria.
    Type: Application
    Filed: January 25, 2002
    Publication date: July 31, 2003
    Inventors: Xinning Wang, Prashant Sawkar, Barbara Chappell