Patents by Inventor Xinqiang Li

Xinqiang Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV integrase inhibitors, pharmaceutical compositions and methods for their use
    Patent number: 7138408
    Abstract: Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: November 21, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Atsuo Kuki, Xinqiang Li, Michael Bruno Plewe, Hai Wang, Junhu Zhang
  • HIV integrase inhibitors, pharmaceutical compositions and methods for their use
    Publication number: 20060122211
    Abstract: Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
    Type: Application
    Filed: October 14, 2005
    Publication date: June 8, 2006
    Inventors: Atsuo Kuki, Xinqiang Li, Michael Plewe, Hai Wang, Junhu Zhang
  • HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use
    Patent number: 7001912
    Abstract: Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: February 21, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Atsuo Kuki, Xinqiang Li, Michael Bruno Plewe, Hai Wang, Junhu Zhang
  • HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use
    Publication number: 20050165040
    Abstract: Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
    Type: Application
    Filed: January 26, 2004
    Publication date: July 28, 2005
    Inventors: Atsuo Kuki, Xinqiang Li, Michael Plewe, Hai Wang, Junhu Zhang
  • Substantially complete ribozyme libraries
    Publication number: 20040259079
    Abstract: The present invention provides a high complexity substantially complete hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.
    Type: Application
    Filed: July 22, 2004
    Publication date: December 23, 2004
    Applicant: Immusol, Inc.
    Inventors: Jack Barber, Peter Welch, Xinqiang Li, Richard Tritz
  • Substantially complete ribozyme libraries
    Publication number: 20030096399
    Abstract: The present invention provides a high complexity substantially complete hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.
    Type: Application
    Filed: February 5, 2002
    Publication date: May 22, 2003
    Applicant: Immusol Incorporated
    Inventors: Jack Barber, Peter Welch, Xinqiang Li, Richard Tritz
  • Inhibition of HIV replication using a mutated transfer RNA primer
    Patent number: 6355790
    Abstract: Modified tRNA molecules are provided which inhibit HIV-1 replication. A tRNA molecule has a modified aminoacyl acceptor stem with a 3′ segment which has reduced complementarity to the HIV primer binding site can initiate aberrant reverse transcription and/or interfere with reverse transcription. tRNA molecules which are modified in regions outside the acceptor stem which interact with reverse trancriptase or the HIV-1 RNA template can also inhibit HIV-1 replication. Methods are disclosed for introducing the modified tRNA molecules into human cells.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: March 12, 2002
    Assignees: University of Rochester, University of California
    Inventors: Joseph D. Rosenblatt, Xinqiang Li