Patents by Inventor Xinqiao Jia

Xinqiao Jia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for inducing bioorthogonal reactivity
    Patent number: 10875840
    Abstract: A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein one R group on the dihydrotetrazine 1 is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the other R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl,- or heteroatom-containing groups; 1, 2 wherein the method comprises oxidizing dihydrotetrazine 1 in a reaction medium in the presence of a catalyst and a stoichiometric oxidant.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: December 29, 2020
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: Joseph Fox, Xinqiao Jia, Will Trout, Joel Rosenthal, Han Zhang, Yinzhi Fang, Colin Thorpe, Shuang Liu, Yixin Xie
  • METHODS FOR INDUCING BIOORTHOGONAL REACTIVITY
    Publication number: 20180362504
    Abstract: A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein one R group on the dihydrotetrazine 1 is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the other R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl,—or heteroatom-containing groups; 1, 2 wherein the method comprises oxidizing dihydrotetrazine 1 in a reaction medium in the presence of a catalyst and a stoichiometric oxidant.
    Type: Application
    Filed: December 15, 2016
    Publication date: December 20, 2018
    Applicant: University of Delaware
    Inventors: Joseph FOX, Xinqiao JIA, Will TROUT, Joel ROSENTHAL, Han ZHANG, Yinzhi FANG, Colin THORPE, Shuang LIU, Yixin XIE
  • Implantable modular hydrogel for salivary gland restoration
    Patent number: 9642941
    Abstract: Implantable modular hydrogels to aid in salivary gland restoration and associated methods are provided. In one embodiment, the present disclosure provides for a hydrogel network comprising: a hyaluronic acid macromer crosslinked with a multiblock copolymer.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 9, 2017
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Robert L. Witt, Xinqiao Jia, Swati Pradham Bhatt, Mary C. Farach-Carson, Daniel A. Harrington
  • Injectable delivery system for heparan-binding growth factors
    Patent number: 9597412
    Abstract: A method for enhancing chondrogenesis in a subject in need thereof comprises administering to the subject an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles (HGPs). The hyaluronic acid (HA)-based hydrogel particles (HGPs) are conjugated with a heparan sulfate proteoglycan (HSPG). Related medicaments and methods for preparing the medicaments are provided.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: March 21, 2017
    Assignee: University of Delaware
    Inventors: Catherine E. Safran, Mary C. Farach-Carson, Xinqiao Jia, Padma P. Srinivasan, Amit Jha
  • IMPLANTABLE MODULAR HYDROGEL FOR SALIVARY GLAND RESTORATION
    Publication number: 20140294960
    Abstract: Implantable modular hydrogels to aid in salivary gland restoration and associated methods are provided. In one embodiment, the present disclosure provides for a hydrogel network comprising: a hyaluronic acid macromer crosslinked with a multiblock copolymer.
    Type: Application
    Filed: June 16, 2014
    Publication date: October 2, 2014
    Inventors: Robert L. Witt, Xinqiao Jia, Swati Pradham Bhatt, Mary C. Farach-Carson, Daniel A. Harrington
  • INJECTABLE DELIVERY SYSTEM FOR HEPARAN-BINDING GROWTH FACTORS
    Publication number: 20140005111
    Abstract: A method for enhancing chondrogenesis in a subject in need thereof comprises administering to the subject an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles (HGPs). The hyaluronic acid (HA)-based hydrogel particles (HGPs) are conjugated with a heparan sulfate proteoglycan (HSPG). Related medicaments and methods for preparing the medicaments are provided.
    Type: Application
    Filed: March 16, 2012
    Publication date: January 2, 2014
    Applicant: UNIVERSITY OF DELAWARE
    Inventors: Catherine B. Safran, Mary C. Farach-Carson, Xinqiao Jia, Padma P. Srinivasa, Amit Jha
  • DYNAMIC VIBRATIONAL METHOD AND DEVICE FOR VOCAL FOLD TISSUE GROWTH
    Publication number: 20100291045
    Abstract: Dynamic vibrational methods and devices for inducing differentiation of stem cells into vocal fold fibroblast-like cells or for generating vocal fold-like tissue from cultured cells. Also provided are matrices providing sustained release of growth factors, and bioreactors generating and delivering a high frequency vibration with in-plane shear stress to cultured cells.
    Type: Application
    Filed: May 17, 2010
    Publication date: November 18, 2010
    Applicant: University of Delaware
    Inventors: Xinqiao Jia, Mingde Jia, Amit K. Jha, Alexandra J.E. Farran, Zhixiang Tong