Patents by Inventor Xinshan Kang
Xinshan Kang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11767296Abstract: Provided herein are compounds of formula (I) having activity on a receptor protein tyrosine kinase, wherein R1, R2, R3, A, Q, Z, X and W are set forth in the description, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof.Type: GrantFiled: March 13, 2019Date of Patent: September 26, 2023Assignee: FUJIAN HAIXI PHARMACEUTICALS CO., LTDInventors: Yan Feng, Ruyong Wang, Junqing Li, Jianjia Zheng, Xin Lian, Xuan Gong, Yueli Fu, Xinshan Kang
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Publication number: 20220380312Abstract: Provided herein are compounds of formula (I) having activity on a receptor protein tyrosine kinase, wherein R1, R2, R3, A, Q, Z, X and W are set forth in the description, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: March 13, 2019Publication date: December 1, 2022Applicant: FUJIAN HAIXI PHARMACEUTICALS CO., LTDInventors: Yan FENG, Ruyong WANG, Junqing LI, Jianjia ZHENG, Xin LIAN, Xuan GONG, Yueli FU, Xinshan KANG
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Patent number: 11247977Abstract: The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.Type: GrantFiled: June 20, 2019Date of Patent: February 15, 2022Assignee: FUJIAN HAIXI PHARMACEUTICALS CO., LTD.Inventors: Yan Feng, Ruyong Wang, Yizhang Ye, Fengsen Zhang, Xuan Gong, Zhonghong Wang, Xinshan Kang
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Publication number: 20210261515Abstract: The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.Type: ApplicationFiled: June 20, 2019Publication date: August 26, 2021Applicant: FUJIAN HAIXI PHARMACEUTICALS CO., LTDInventors: Yan FENG, Ruyong WANG, Yizhang YE, Fengsen ZHANG, Xuan GONG, Zhonghong WANG, Xinshan KANG
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Patent number: 9603848Abstract: The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.Type: GrantFiled: June 8, 2007Date of Patent: March 28, 2017Assignee: Senomyx, Inc.Inventors: Guy Servant, Xiaodong Li, Feng Zhang, Haitian Liu, Catherine Tachdjian, Xiao-Qing Tang, Sara Werner, Marketa Rinnova, Qing Chen, Albert Zlotnik, Mark Zoller, Boris Klebansky, Richard Fine, Xinshan Kang
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Patent number: 9409900Abstract: The compound of Formula (I), pharmaceutically acceptable salts thereof, solvates thereof, chelates thereof, non-covalent complexes thereof or produgs of compounds mentioned above or the mixture of any form above mentioned are provided. The use of the compounds in manufacturing a medicament for the treatment and/or prevention of diabetes, obesity and related disorders.Type: GrantFiled: November 9, 2011Date of Patent: August 9, 2016Assignees: FUJIAN HAIXI PHARMACEUTICALS, INC., BETTA PHARMACUETICALS CO., LTD.Inventors: Xinshan Kang, Wei Long, Cunbo Ma, Yanping Wang, Xiaoyan Shen, Yunyan Hu, Fenlai Tan, Yinxiang Wang
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Publication number: 20160200734Abstract: The invention relates to compounds for increasing QPR40 receptor activity and application thereof. These compounds include of a compound of Formula (I), pharmaceutically acceptable salts thereof, solvates thereof, isomers thereof, or produgs of the compounds mentioned above, or the mixture of any form above mentioned. The invention also relates to the use of the compounds in manufacturing a medicament for the treatment and/or prevention of diabetes, obesity or for Insulin secretagogue.Type: ApplicationFiled: August 22, 2014Publication date: July 14, 2016Inventors: Xinshan KANG, Zhonghui CHEN
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Patent number: 9238637Abstract: The polymorphic forms of the compound of Formula I, the preparation thereof including the preparation of the intermediates, the pharmaceutical compositions thereof and the uses of a polymorph above in the manufacture of medicaments for treating a disease, a disorder or a condition are disclosed.Type: GrantFiled: July 30, 2012Date of Patent: January 19, 2016Assignee: BEIJING BETTA PHARMACEUTICALS CO., LTDInventors: Xinshan Kang, Wei Long, Fei Wang, Cunbo Ma, Liufeng Zhou, Yunyan Hu, Yanping Wang, Hong Cao, Yinxiang Wang, Fenlai Tan
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Patent number: 9206134Abstract: The present invention relates to the polymorphic forms of the compound of Formula (I), preparation thereof including the preparation of intermediates and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder or a condition, or in the manufacturing of a medicament for the treatment of a disease, a disorder or a condition.Type: GrantFiled: July 23, 2012Date of Patent: December 8, 2015Assignee: BEIJING BETTA PHARMACEUTICALS CO. LTD.Inventors: Xinshan Kang, Wei Long, Jianxi Zhang, Yunyan Hu, Yinxiang Wang
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Patent number: 9181276Abstract: The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.Type: GrantFiled: November 12, 2013Date of Patent: November 10, 2015Assignee: Senomyx, Inc.Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Xiaodong Li, Feng Zhang, Guy Servant, Qing Chen, Vincent Darmohusodo, Richard Fine, Joseph R. Fotsing, Jeffrey Robert Hammaker, Xinshan Kang, Rachel D. A. Kimmich, Boris Klebansky, Haitian Liu, Goran Petrovic, Marketa Rinnova, Sara Adamski-Werner, Jeffrey Yamamoto, Hong Zhang, Albert Zlotnik
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Publication number: 20150031721Abstract: The present invention relates to the polymorphic forms of the compound of Formula (I), preparation thereof including the preparation of intermediates and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder or a condition, or in the manufacturing of a medicament for the treatment of a disease, a disorder or a condition.Type: ApplicationFiled: July 23, 2012Publication date: January 29, 2015Inventors: Xinshan Kang, Wei Long, Jianxi Zhang, Yunyan Hu, Yinxiang Wang
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Publication number: 20140343137Abstract: The polymorphic forms of the compound of Formula I, the preparation thereof including the preparation of the intermediates, the pharmaceutical compositions thereof and the uses of a polymorph above in the manufacture of medicaments for treating a disease, a disorder or a condition are disclosed.Type: ApplicationFiled: July 30, 2012Publication date: November 20, 2014Applicants: BEIJING BETTA PHARMACEUTICALS CO., LTD.Inventors: Xinshan Kang, Wei Long, Fei Wang, Cunbo Ma, Liufeng Zhou, Yunyan Hu, Yanping Wang, Hong Cao, Yinxiang Wang, Fenlai Tan
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Publication number: 20140235623Abstract: The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.Type: ApplicationFiled: November 12, 2013Publication date: August 21, 2014Applicant: SENOMYX, INC.Inventors: Catherine TACHDJIAN, Donald S. KARANEWSKY, Xiao-Qing TANG, Xiaodong LI, Feng ZHANG, Guy SERVANT, Qing CHEN, Vincent DARMOHUSODO, Richard FINE, Joseph R. FOTSING, Jeffrey Robert HAMMAKER, Xinshan KANG, Rachel D.A. KIMMICH, Boris KLEBANSKY, Haitian LIU, Goran PETROVIC, Marketa RINNOVA, Sara ADAMSKI-WERNER, Jeffrey YAMAMOTO, Hong ZHANG, Albert ZLOTNIK
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Patent number: 8742138Abstract: This invention relates to new compounds that can serve as hypoxia mimetics. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one of these compounds.Type: GrantFiled: July 14, 2010Date of Patent: June 3, 2014Assignees: Betta Pharmaceuticals Co., Ltd.Inventors: Xinshan Kang, Wei Long, Cunbo Ma, Yanping Wang, Hong Cao, Yinxiang Wang, Fenlai Tan, Yunyan Hu
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Patent number: 8633186Abstract: The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.Type: GrantFiled: June 3, 2008Date of Patent: January 21, 2014Assignee: Senomyx Inc.Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Xiaodong Li, Feng Zhang, Guy Servant, Qing Chen, Vincent Darmohusodo, Richard Fine, Joseph R. Fotsing, Jeffrey Robert Hammaker, Xinshan Kang, Rachel D. A. Kimmich, Boris Klebansky, Haitian Liu, Goran Petrovic, Marketa Rinnova, Sara Adamski-Werner, Jeffrey Yamamoto, Hong Zhang, Albert Zlotnik, Karen Zoller
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Patent number: 8541421Abstract: The present invention provides, in part, substituted thieno[2,3-d]pyrimidines and methods of contacting compositions with such compounds to enhance the sweet taste of said compositions.Type: GrantFiled: March 18, 2011Date of Patent: September 24, 2013Assignee: Senomyx Inc.Inventors: Catherine Tachdjian, Xiao-Qing Tang, Sara Werner, Marketa Rinnova, Qing Chen, Guy Servant, Xiaodong Li, Feng Zhang, Haitian Liu, Albert Zlotnik, Mark Zoller, Boris Klebansky, Richard Fine, Xinshan Kang
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Publication number: 20130225587Abstract: The compound of Formula (I), pharmaceutically acceptable salts thereof, solvates thereof, chelates thereof, non-covalent complexes thereof or produgs of compounds mentioned above or the mixture of any form above mentioned are provided. The use of the compounds in manufacturing a medicament for the treatment and/or prevention of diabetes, obesity and related disorders.Type: ApplicationFiled: November 9, 2011Publication date: August 29, 2013Applicants: Zhejiang Beta Pharma Incorporation, Fujian Haixi Pharmaceuticals, Inc.Inventors: Xinshan Kang, Wei Long, Cunbo Ma, Yanping Wang, Xiaoyan Shen, Yunyan Hu, Fenlai Tan, Yinxiang Wang
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Publication number: 20120172399Abstract: This invention relates to new compounds that can serve as hypoxia mimetics. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one of these compounds.Type: ApplicationFiled: July 14, 2010Publication date: July 5, 2012Inventors: Xinshan Kang, Wei Long, Cunbo Ma, Yanping Wang, Hong Cao, Yinxiang Wang, Fenlai Tan, Yunyan Hu
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Publication number: 20110230502Abstract: The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.Type: ApplicationFiled: March 18, 2011Publication date: September 22, 2011Applicant: SENOMYX, INC.Inventors: Catherine TACHDJIAN, Xiao-Qing Tang, Sara Werner, Marketa Rinnova, Qing Chen, Guy Servant, Xiaodong Li, Feng Zhang, Haitian Liu, Albert Zlotnik, Mark Zoller, Boris Klebansky, Richard Fine, Xinshan Kang
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Publication number: 20110224155Abstract: The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.Type: ApplicationFiled: June 3, 2008Publication date: September 15, 2011Applicant: SENOMYX INC.Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Xiaodong Li, Feng Zhang, Guy Servant, Qing Chen, Vincent Darmohusodo, Richard Fine, Joseph R. Fotsing, Jeffrey Robert Hammaker, Xinshan Kang, Rachel D.A. Kimmich, Boris Klebansky, Haitian Liu, Goran Petrovic, Marketa Rinnova, Sara Adamski-Werner, Jeffrey Yamamoto, Hong Zhang, Albert Zlotnik, Mark Zoller, Karen Zoller