Patents by Inventor Xinshe Xu

Xinshe Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATED POLYMERS AND METHODS OF USE
    Publication number: 20230109663
    Abstract: The present disclosure provides fluorescent polyindenofluorene polymers or macromers with unique optical properties that are stable. The polymeric fluorophores are useful in various bioassays formats. The inventive polymers are useful in assays relying on fluorescence resonance energy transfer (FRET) mechanisms where two fluorophores are used.
    Type: Application
    Filed: November 30, 2022
    Publication date: April 6, 2023
    Applicant: BioLegend, Inc.
    Inventors: XINSHE XU, Jing Wang, Matthew Yerou
  • Conjugated polymers and methods of use
    Patent number: 11584883
    Abstract: The present disclosure provides fluorescent polyindenofluorene polymers or macromers with unique optical properties that are stable. The polymeric fluorophores are useful in various bioassays formats. The inventive polymers are useful in assays relying on fluorescence resonance energy transfer (FRET) mechanisms where two fluorophores are used.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: February 21, 2023
    Assignee: BIOLEGEND, INC.
    Inventors: Xinshe Xu, Jing Wang, Matthew Yerou
  • SUBSTITUTED POLYFLUORENE COMPOUNDS
    Publication number: 20220002552
    Abstract: The present invention provides fluorescent polyfluorene polymers or macromers with unique optical properties that are stable. The polymeric fluorophores are useful in various bioassays formats. The inventive polymers are useful in assays relying on fluorescence resonance energy transfer (FRET) mechanisms where two fluorophores are used.
    Type: Application
    Filed: September 8, 2021
    Publication date: January 6, 2022
    Applicant: BIOLEGEND, INC.
    Inventors: Xinshe Xu, Jing Wang
  • Substituted polyfluorene compounds
    Patent number: 11155714
    Abstract: The present invention provides fluorescent polyfluorene polymers or macromers with unique optical properties that are stable. The polymeric fluorophores are useful in various bioassays formats. The inventive polymers are useful in assays relying on fluorescence resonance energy transfer (FRET) mechanisms where two fluorophores are used.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: October 26, 2021
    Assignee: BIOLEGEND, INC.
    Inventors: Xinshe Xu, Jing Wang
  • Phthalocyanine formulation and uses thereof
    Patent number: 10988687
    Abstract: The present invention provides a chemiluminescent ink formulation, comprising: a phthalocyanine metal catalyst; a visible dye; and a solvent. The formulation is useful in catalyzing a chemiluminescent reaction, by admixing for example, luminol or isoluminol with an oxidizing agent, a base and the chemiluminescent ink formulation to emit light.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: April 27, 2021
    Assignee: LI-COR, INC.
    Inventors: Xinshe Xu, Rose Skopp, Mark Cradduck, Nisha Padhye
  • CONJUGATED POLYMERS AND METHODS OF USE
    Publication number: 20200239766
    Abstract: The present disclosure provides fluorescent polyindenofluorene polymers or macromers with unique optical properties that are stable. The polymeric fluorophores are useful in various bioassays formats. The inventive polymers are useful in assays relying on fluorescence resonance energy transfer (FRET) mechanisms where two fluorophores are used.
    Type: Application
    Filed: December 3, 2019
    Publication date: July 30, 2020
    Applicant: BioLegend
    Inventors: Xinshe Xu, Jing Wang, Matthew Yerou
  • SUBSTITUTED POLYFLUORENE COMPOUNDS
    Publication number: 20190203052
    Abstract: The present invention provides fluorescent polyfluorene polymers or macromers with unique optical properties that are stable. The polymeric fluorophores are useful in various bioassays formats. The inventive polymers are useful in assays relying on fluorescence resonance energy transfer (FRET) mechanisms where two fluorophores are used.
    Type: Application
    Filed: January 4, 2019
    Publication date: July 4, 2019
    Applicant: BioLegend
    Inventors: Xinshe Xu, Jing Wang
  • PHTHALOCYANINE FORMULATION AND USES THEREOF
    Publication number: 20180079954
    Abstract: The present invention provides a chemiluminescent ink formulation, comprising: a phthalocyanine metal catalyst; a visible dye; and a solvent. The formulation is useful in catalyzing a chemiluminescent reaction, by admixing for example, luminol or isoluminol with an oxidizing agent, a base and the chemiluminescent ink formulation to emit light.
    Type: Application
    Filed: November 29, 2017
    Publication date: March 22, 2018
    Applicant: LI-COR, Inc.
    Inventors: Xinshe Xu, Rose Skopp, Mark Cradduck, Nisha Padhye
  • Phthalocyanine formulation and uses thereof
    Patent number: 9845430
    Abstract: The present invention provides a chemiluminescent ink formulation, comprising: a phthalocyanine metal catalyst; a visible dye; and a solvent. The formulation is useful in catalyzing a chemiluminescent reaction, by admixing for example, luminol or isoluminol with an oxidizing agent, a base and the chemiluminescent ink formulation to emit light.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: December 19, 2017
    Assignee: LI-COR, Inc.
    Inventors: Xinshe Xu, Rose Skopp, Mark Cradduck, Nisha Padhye
  • Fluorogenic and chromogenic substrate
    Patent number: 9632034
    Abstract: The present invention provides near-infrared fluorogenic and/or chromogenic formulations, methods, systems and kits. Upon contacting an azine with an oxidant and a peroxidase, the azine is converted to an azine derivative which is both visibly colored and fluorescent. This invention also provides high sensitive methods to detect biological molecules, showing better sensitivity than chemiluminescence methods. Advantageously, the formulation and reaction is free of luminol or luminol derivatives.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 25, 2017
    Assignee: LI-COR, Inc.
    Inventors: Ying Wang, Xinshe Xu, Nisha Padhye
  • FLUOROGENIC AND CHROMOGENIC SUBSTRATE
    Publication number: 20160266045
    Abstract: The present invention provides near-infrared fluorogenic and/or chromogenic formulations, methods, systems and kits. Upon contacting an azine with an oxidant and a peroxidase, the azine is converted to an azine derivative which is both visibly colored and fluorescent. This invention also provides high sensitive methods to detect biological molecules, showing better sensitivity than chemiluminescence methods. Advantageously, the formulation and reaction is free of luminol or luminol derivatives.
    Type: Application
    Filed: March 11, 2016
    Publication date: September 15, 2016
    Applicant: LI-COR, Inc.
    Inventors: Ying Wang, Xinshe Xu, Nisha Padhye
  • Bioconjugates of cyanine dyes
    Patent number: 9408924
    Abstract: Compounds are disclosed that are useful for noninvasive imaging in the near-infrared spectral range.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: August 9, 2016
    Assignee: LI-COR, INC.
    Inventors: Xinshe Xu, Daniel R. Draney, Lael Cheung
  • PHTHALOCYANINE FORMULATION AND USES THEREOF
    Publication number: 20150267108
    Abstract: The present invention provides a chemiluminescent ink formulation, comprising: a phthalocyanine metal catalyst; a visible dye; and a solvent. The formulation is useful in catalyzing a chemiluminescent reaction, by admixing for example, luminol or isoluminol with an oxidizing agent, a base and the chemiluminescent ink formulation to emit light.
    Type: Application
    Filed: April 25, 2014
    Publication date: September 24, 2015
    Inventors: Xinshe Xu, Rose Skopp, Mark Cradduck, Nisha Padhye
  • Fluorescent imaging with substituted cyanine dyes
    Patent number: 9089603
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 28, 2015
    Assignee: LI-COR, INC.
    Inventors: Xinshe Xu, Daniel R. Draney, Mark Cradduck, Lael Cheung, Kousik Kundu, William M. Volcheck
  • BIOCONJUGATES OF CYANINE DYES
    Publication number: 20150119553
    Abstract: Compounds are disclosed that are useful for noninvasive imaging in the near-infrared spectral range.
    Type: Application
    Filed: November 24, 2014
    Publication date: April 30, 2015
    Inventors: Xinshe Xu, Daniel R. Draney, Lael Cheung
  • Cyanine dyes and their conjugates
    Patent number: 8927719
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 6, 2015
    Assignee: Li-Cor, Inc.
    Inventors: Xinshe Xu, Daniel R. Draney, Lael Cheung
  • CYANINE DYES AND THEIR CONJUGATES
    Publication number: 20130274452
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 17, 2013
    Inventors: Xinshe Xu, Daniel R. Draney, Lael Cheung
  • Fluorescent imaging with substituted cyanine dyes
    Patent number: 8481752
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: July 9, 2013
    Assignee: Li-Cor, Inc.
    Inventors: Xinshe Xu, Daniel R. Draney
  • OPTICAL FLUORESCENT IMAGING IN HISTOLOGY
    Publication number: 20130052637
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Application
    Filed: August 29, 2012
    Publication date: February 28, 2013
    Applicant: LI-COR, INC.
    Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
  • OPTICAL FLUORESCENT IMAGING
    Publication number: 20120258048
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 11, 2012
    Applicant: LI-COR, INC.
    Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan