Patents by Inventor Xinsheng Tian

Xinsheng Tian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AN INTERLEUKIN-1 RECEPTOR ANTAGONIST AND A FUSION PROTEIN CONTAINING THE SAME
    Publication number: 20240018206
    Abstract: Provided is an Interleukin-1 Receptor Antagonist (IL-1RN) protein or a variant or analogue thereof, and a fusion protein comprising the following three-parts: the Interleukin-1 Receptor Antagonist protein or a variant or analogue thereof, a domain for half-life extension and an optional tumor necrosis factor receptor 2, and the preparation method and use thereof. The above-mentioned protein mutant and fusion protein have the effects of extended half-life, improved affinity with interleukin-1 receptor and superior biological activity, and find use in the field of treatment and prevention of inflammatory-associated diseases.
    Type: Application
    Filed: July 9, 2020
    Publication date: January 18, 2024
    Inventors: Ziqiang LI, Rong MA, Xinsheng TIAN, Yiping SUN, Yiren LIU, Shaokui LI
  • FUSION POLYPEPTIDE
    Publication number: 20230242615
    Abstract: Provided is a fusion polypeptide as an antagonist for IL4 and IL13. Also provided is a pharmaceutical composition comprising the fusion polypeptide and a pharmaceutically acceptable excipient.
    Type: Application
    Filed: December 9, 2022
    Publication date: August 3, 2023
    Inventors: Ziqiang Li, Xinsheng Tian, Yiping Sun, Yiren Liu, Shaokui Li