Patents by Inventor Xinxin Gao
Xinxin Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108561Abstract: Dentifrice compositions comprising water, bicarbonate salt, and glycine or a salt thereof are effective in treating dental plaque biofilm. A dentifrice composition may include from about 15% to about 55%, by weight of the composition, of water, from about 20% to about 40% by weight of the composition, of sodium bicarbonate, from about 0.05% to about 5%, by weight of the composition, of neutral amino acid, where the neutral amino acid comprises glycine or a salt thereof, and from about 0.0025% to about 2%, by weight of the composition, of fluoride.Type: ApplicationFiled: December 6, 2023Publication date: April 4, 2024Inventors: Ross STRAND, Yunming SHI, Zhaoxin Gao, Xinxin LI
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Publication number: 20240059755Abstract: The present invention generally relates to nanolipoprotein particle conjugates comprising at least one polypeptide and nanolipoprotein particle conjugates comprising at least one short peptide between 20-60 amino acids in length. Also provided are related compositions and systems, and methods of preparing and using same. In particular, nanolipoprotein particle (NLP) conjugates with antigen-binding fragments (Fabs) are provided, where the NLP comprises a bilayer of membrane-forming lipids encircled by scaffold proteins, and the Fabs are conjugated to one or both bilayer surfaces. In some embodiments, the (NLP) conjugates further comprise a short peptide 20-60 amino acids in length.Type: ApplicationFiled: December 9, 2022Publication date: February 22, 2024Applicant: Genentech, IncInventors: Whitney BINDER, Craig D. BLANCHETTE, Martine A. DARWISH, Rami HANNOUSH, Xinxin GAO
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Publication number: 20230174596Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: ApplicationFiled: June 17, 2022Publication date: June 8, 2023Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
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Patent number: 11407794Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: GrantFiled: August 19, 2019Date of Patent: August 9, 2022Assignee: Genetech, Inc.Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
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Patent number: 11155586Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: GrantFiled: September 18, 2019Date of Patent: October 26, 2021Assignee: Genentech, Inc.Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
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Patent number: 11078243Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: GrantFiled: September 18, 2019Date of Patent: August 3, 2021Assignee: Genentech, Inc.Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
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Publication number: 20200325187Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, Including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: ApplicationFiled: June 29, 2020Publication date: October 15, 2020Applicant: Genentech, Inc.Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
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Publication number: 20200231636Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: ApplicationFiled: September 18, 2019Publication date: July 23, 2020Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
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Patent number: 10696721Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: GrantFiled: April 3, 2018Date of Patent: June 30, 2020Assignee: Genentech, Inc.Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
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Publication number: 20200140498Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: ApplicationFiled: September 18, 2019Publication date: May 7, 2020Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
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Publication number: 20200115424Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: ApplicationFiled: August 19, 2019Publication date: April 16, 2020Applicant: Genentech, Inc.Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
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Patent number: 10428125Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: GrantFiled: September 15, 2016Date of Patent: October 1, 2019Assignee: Genentech, Inc.Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
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Publication number: 20180291069Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: ApplicationFiled: April 3, 2018Publication date: October 11, 2018Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
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Publication number: 20170129927Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.Type: ApplicationFiled: September 15, 2016Publication date: May 11, 2017Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
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Patent number: 9017962Abstract: The invention provides a variety of molecular tools for use in live-cell tracking of activities of biomolecules and in high-throughput drug screening.Type: GrantFiled: August 20, 2008Date of Patent: April 28, 2015Assignee: The Johns Hopkins UniversityInventors: Jin Zhang, Robert Howard Newman, Xinxin Gao, Michael David Allen, Matthew David Fosbrink
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Publication number: 20110275103Abstract: Phosphoinositide-dependent kinase 1 (PDK1) activity reporters can be used in high throughput assays for drug screening.Type: ApplicationFiled: April 28, 2011Publication date: November 10, 2011Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Jin Zhang, Xinxin Gao
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Publication number: 20100202970Abstract: The invention provides a variety of molecular tools for use in live-cell tracking of activities of biomolecules and in high-throughput drug screening.Type: ApplicationFiled: August 20, 2008Publication date: August 12, 2010Applicant: The Johns Hopkins UniversityInventors: Jin Zhang, Robert Howard Newman, Xinxin Gao, Michael David Allen, Matthew David Fosbrink