Abstract: The present disclosure relates to an siRNA for inhibiting the expression of an angiopoietin-like protein 3 (ANGPTL3) gene, an siRNA conjugate, and a pharmaceutical composition thereof, and a method for reducing the expression of the ANGPTL3 gene by using the siRNA, the siRNA conjugate, and the pharmaceutical composition thereof. The siRNA, the siRNA conjugate, and the pharmaceutical composition thereof of the present disclosure can be used for treating and/or preventing an ANGPTL3 gene-mediated disease or disorder.

Abstract: There are provided inhibin subunit beta E (INHBE) inhibitors such as RNAi agents and RNAs useful for inhibiting the expression of INHBE, pharmaceutical compositions thereof, and applications thereof in the prevention and/or treatment of INHBE-associated disorders, e.g., metabolic disorders such as metabolic syndrome. In some embodiments the RNAi agents and RNAs comprise at least one non-canonical base pairing nucleotide.

Abstract: A plasma source ion implanter with a preparation chamber for linear or cross transferring workpiece is provided to solve the problem of low production efficiency of an existing single vacuum chamber plasma source ion implanter. The ion implanter includes a preparation chamber, an implantation chamber and a workpiece transferring chamber. The implantation chamber is provided to maintain a high vacuum condition all the time, and the time for pre-vacuuming the base vacuum is ignored. The ion implanter with dual chamber configuration is able to greatly shorten the production cycle. The structural configurations of the preparation chamber and the implantation chamber are basically the same, and are adapted to be used independently when ion implantation is required for a long time.

Abstract: High-frequency hot-pressing continuous automatic production lines for dimensional bamboo timbers, and production methods thereof are provided. The production line can include a clip-up store and feeding mechanism fixed with one end of a three-roller type gluing system. An other end of the three-roller type gluing system is fixed with one end of a system for loading, layer up and stacking non-glued bamboo sheets. The outer side edge of the system for loading, layer up and stacking non-glued bamboo sheets is connected to a front inner end of a plate stack conveying system. A high-frequency press and high-frequency generator system is located at a rear inner end of the system for loading, layer up and stacking non-glued bamboo sheets.

Abstract: A plasma source ion implanter with a preparation chamber for linear or cross transferring workpiece is provided to solve the problem of low production efficiency of an existing single vacuum chamber plasma source ion implanter. The ion implanter includes a preparation chamber, an implantation chamber and a workpiece transferring chamber. The implantation chamber is provided to maintain a high vacuum condition all the time, and the time for pre-vacuuming the base vacuum is ignored. The ion implanter with dual chamber configuration is able to greatly shorten the production cycle. The structural configurations of the preparation chamber and the implantation chamber are basically the same, and are adapted to be used independently when ion implantation is required for a long time.

Abstract: There are provided bivalent compounds and conjugates thereof, the conjugates comprising a bivalent compound, a targeting moiety, and a bioactive agent, as well as pharmaceutical compositions and methods of use of the conjugate for the treatment, inhibition, or prevention of diseases and disorders which are therapeutic targets of the bioactive agent.

Abstract: High-frequency hot-pressing continuous automatic production lines for dimensional bamboo timbers, and production methods thereof are provided. The production line can include a clip-up store and feeding mechanism fixed with one end of a three-roller type gluing system. An other end of the three-roller type gluing system is fixed with one end of a system for loading, layer up and stacking non-glued bamboo sheets. The outer side edge of the system for loading, layer up and stacking non-glued bamboo sheets is connected to a front inner end of a plate stack conveying system. A high-frequency press and high-frequency generator system is located at a rear inner end of the system for loading, layer up and stacking non-glued bamboo sheets.

Abstract: A method for effectively controlling harmful organisms in the large-scale culture of microalgae comprises the following steps: (1) determining the harmful organism species causing contamination to the microalgae in culture, and the acid and alkali tolerance levels of said harmful organism species; and (2) adjusting the pH value of the microalgae culture system according to the different acid and alkali tolerance levels of the harmful organisms; when the harmful organisms are determined to be killed or inhibited effectively, adjusting the pH value back to be suitable for the normal growth of the microalgae. After the treatment, common harmful protozoa in the culturing processes of most microalgae (green algae, blue algae and variegated algae) can be controlled effectively, and the method is also effective on certain miscellaneous algae contamination.

Abstract: A method for effectively controlling harmful organisms in the large-scale culture of microalgae comprises the following steps: (1) determining the harmful organism species causing contamination to the microalgae in culture, and the acid and alkali tolerance levels of said harmful organism species; and (2) adjusting the pH value of the microalgae culture system according to the different acid and alkali tolerance levels of the harmful organisms; when the harmful organisms are determined to be killed or inhibited effectively, adjusting the pH value back to be suitable for the normal growth of the microalgae. After the treatment, common harmful protozoa in the culturing processes of most microalgae (green algae, blue algae and variegated algae) can be controlled effectively, and the method is also effective on certain miscellaneous algae contamination.