Patents by Inventor Xinxin Sang
Xinxin Sang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132410Abstract: The invention presents a near-infrared photothermal coupling curing non-oxide ceramic slurry, along with its preparation method and application. The ceramic slurry consists of various raw materials, with weight fractions as follows: non-oxide ceramic powder (40˜90 parts), photosensitive resin (0.5˜20 parts), photosensitive monomer (1˜40 parts), photoinitiator (0.25˜4 parts), thermal initiator (0.25˜4 parts), additive (0.75˜5 parts), and up-conversion luminescent material (0.5˜4 parts). The non-oxide ceramic powders can include Si3N4, TiN, BN, AlN, SiC, WC, TiC, ZrC, TiB2, and ZrB2. By combining the photochemical and photothermal dual curing system using near-infrared up-conversion, this invention addresses the issue of insufficient curing encountered in single photocuring or thermal curing processes.Type: ApplicationFiled: July 30, 2023Publication date: April 25, 2024Inventors: Ren LIU, Xinxin SANG, Yongqin ZHAO, Jiatao MIAO
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Publication number: 20240132733Abstract: A method is described for preparing metal ink for additive manufacturing based on photo-thermal synergistic curing, relating to functional ink technology. The ink includes 50%-95% metal powder, 1%-35% photosensitive resin, 1%-35% photosensitive monomer, 0.1%-7% photoinitiator, 0.1%-5% thermal initiator, 0.1%-5% up-conversion material, and 0%-2% auxiliary agent. The method includes adding metal ink to the ink tank of a direct ink writing 3D printer, extruding the metal ink from the nozzle under computer control to the printing specific shapes on the platform, and curing under real-time illumination of a specific light source to obtain the green body. The method includes performing high-temperature debinding treatment on the obtained green body in a specific atmosphere. The treated green body is subjected to a high-temperature and high-pressure sintering treatment in a specific atmosphere and then cooled to room temperature.Type: ApplicationFiled: August 28, 2023Publication date: April 25, 2024Inventors: Ren LIU, Guo Wei, Junzhao Yuan, Xinxin Sang
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Patent number: 11510874Abstract: A method for making reduction sensitive nano micelles comprising: 1) dissolving taurine in distilled water, and adding sodium hydroxide solution; 2) dissolving acryloyl chloride in dichloromethane, reacting at 25° C.; dissolving lipoic acid in toluene and adding hydroxyethyl methacrylate, reacting at 85° C.; 3) dissolving N-acryloyltaurine and lipoic acid methacryloyloxyethyl ester and reacting at 60˜65° C., dropping the polymer solution into deionized water, adding dithiothreitol and reacting at 25˜30° C. to obtain reduction sensitive nano micelles after freeze-drying. The nano micelles have regular morphology and uniform distribution, and can be used as drug carriers for controlled release.Type: GrantFiled: December 31, 2020Date of Patent: November 29, 2022Assignee: JIANGNAN UNIVERSITYInventors: Liping Zhang, Caihua Ni, Xinxin Sang, Gang Shi
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Publication number: 20220054415Abstract: A method for making reduction sensitive nano micelles comprising: 1) dissolving taurine in distilled water, and adding sodium hydroxide solution; 2) dissolving acryloyl chloride in dichloromethane, reacting at 25° C.; dissolving lipoic acid in toluene and adding hydroxyethyl methacrylate, reacting at 85° C.; 3) dissolving N-acryloyltaurine and lipoic acid methacryloyloxyethyl ester and reacting at 60˜65° C., dropping the polymer solution into deionized water, adding dithiothreitol and reacting at 25˜30° C. to obtain reduction sensitive nano micelles after freeze-drying. The nano micelles have regular morphology and uniform distribution, and can be used as drug carriers for controlled release.Type: ApplicationFiled: December 31, 2020Publication date: February 24, 2022Inventors: Caihua NI, Liping ZHANG, Xinxin Sang, Gang SHI
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Patent number: 11203523Abstract: The present invention discloses a bionic SERS substrate of a metal-based compound eye bowl structure, a construction method and application. The bionic SERS substrate of the metal-based compound eye bowl structure of the present invention consists of a metal bowl and a cone-shaped structure substrate in an ordered hierarchy manner. The metal bowl is of a continuously and closely arranged single-layer bowl structure. A height of the metal bowl is 0.01-10 ?m, and a bowl opening diameter is 0.01-10 ?m. A cone is a micron pyramid cone, and a height of the micron pyramid cone is 1-100 ?m. The present invention assembles the metal bowl on a surface of the substrate of the micron pyramid cone structure with great fluctuation by a solid-liquid interface chemical reduction method and a small ball template method, and further constructs a 3D SERS substrate with a bionic compound eye structure.Type: GrantFiled: October 28, 2020Date of Patent: December 21, 2021Assignee: JIANGNAN UNIVERSITYInventors: Gang Shi, Ying Li, Jianhua Li, Xuan Jin, Dawei Wang, Likui Wang, Jingguo Yang, Xinxin Sang, Caihua Ni
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Patent number: 11119047Abstract: The present invention discloses an SERS substrate of a metal-modified semiconductor-based bionic compound eye bowl structure and a construction method, and belongs to the technical field of nano materials. The present invention is based on a multi-time interface self-assembly method. Firstly, a small ball template is constructed by using a gas-liquid interface assembly process. Then, a semiconductor bowl structure array is induced to be formed by the template by using a solid-liquid interface assembly process. Next, a semiconductor bowl is assembled to a surface of a pyramid-shaped cone to form a bionic compound eye structure by using a transfer process. Finally, a surface of the bionic compound eye structure is modified with a layer of uniformly distributed metal particles by a physical deposition method or a chemical deposition method, thereby forming the SERS substrate of the metal-modified semiconductor-based bionic compound eye bowl structure.Type: GrantFiled: October 28, 2020Date of Patent: September 14, 2021Assignee: JIANGNAN UNIVERSITYInventors: Gang Shi, Ying Li, Jie Chen, Xuan Jin, Likui Wang, Dawei Wang, Jingguo Yang, Xinxin Sang, Caihua Ni
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Publication number: 20210114868Abstract: The present invention discloses a bionic SERS substrate of a metal-based compound eye bowl structure, a construction method and application. The bionic SERS substrate of the metal-based compound eye bowl structure of the present invention consists of a metal bowl and a cone-shaped structure substrate in an ordered hierarchy manner. The metal bowl is of a continuously and closely arranged single-layer bowl structure. A height of the metal bowl is 0.01-10 ?m, and a bowl opening diameter is 0.01-10 ?m. A cone is a micron pyramid cone, and a height of the micron pyramid cone is 1-100 ?m. The present invention assembles the metal bowl on a surface of the substrate of the micron pyramid cone structure with great fluctuation by a solid-liquid interface chemical reduction method and a small ball template method, and further constructs a 3D SERS substrate with a bionic compound eye structure.Type: ApplicationFiled: October 28, 2020Publication date: April 22, 2021Inventors: Gang Shi, Ying Li, Jianhua Li, Xuan Jin, Dawei Wang, Likui Wang, Jingguo Yang, Xinxin Sang, Caihua Ni
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Publication number: 20210109025Abstract: The present invention discloses an SERS substrate of a metal-modified semiconductor-based bionic compound eye bowl structure and a construction method, and belongs to the technical field of nano materials. The present invention is based on a multi-time interface self-assembly method. Firstly, a small ball template is constructed by using a gas-liquid interface assembly process. Then, a semiconductor bowl structure array is induced to be formed by the template by using a solid-liquid interface assembly process. Next, a semiconductor bowl is assembled to a surface of a pyramid-shaped cone to form a bionic compound eye structure by using a transfer process. Finally, a surface of the bionic compound eye structure is modified with a layer of uniformly distributed metal particles by a physical deposition method or a chemical deposition method, thereby forming the SERS substrate of the metal-modified semiconductor-based bionic compound eye bowl structure.Type: ApplicationFiled: October 28, 2020Publication date: April 15, 2021Inventors: Gang Shi, Ying Li, Jie Chen, Xuan Jin, Likui Wang, Dawei Wang, Jingguo Yang, Xinxin Sang, Caihua Ni
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Patent number: 10933028Abstract: The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of ?-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(?-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.Type: GrantFiled: December 3, 2018Date of Patent: March 2, 2021Assignee: JIANGNAN UNIVERSITYInventors: Liping Zhang, Caihua Ni, Ren Liu, Dawei Wang, Gang Shi, Xinxin Sang, Xiaofeng Xia
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Publication number: 20200281865Abstract: The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of ?-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(?-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.Type: ApplicationFiled: December 3, 2018Publication date: September 10, 2020Inventors: Liping ZHANG, Caihua NI, Ren LIU, Dawei WANG, Gang SHI, Xinxin SANG, Xiaofeng XIA
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Patent number: 10632071Abstract: Disclosed is a preparation method for charge reversal and reversibly crosslinked redox-sensitive nanomicelles, falling within the technical field of biomedical materials. The method comprises: synthesizing thiocinamide from lipoic acid and ethylenediamine under an N,N?-carbonyl diimidazole catalyst; and polymerizing thiocinamide, polyethylene glycol diglycidyl ether and lysine through a nucleophilic addition mechanism to prepare a poly(lysine-co-polyethylene glycol diglycidyl ether-co-thiocinamide) terpolymer. The micelle is endowed with excellent anti-protein nonspecific adsorption and enhanced cell uptake property through a self-assembly and protonation/deprotonation action; and a disulfide bond in lipoyl may form a linear polydisulfide structure under the action of 1,4-dithiothreitol, so that a micelle core is crosslinked, and a crosslinked structure is destroyed in the cell under a redox condition, and controlled release of a drug can be achieved.Type: GrantFiled: April 27, 2017Date of Patent: April 28, 2020Assignee: JIANGNAN UNIVERSITYInventors: Liping Zhang, Ren Liu, Caihua Ni, Yuanyuan Ding, Gang Shi, Xinxin Sang
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Publication number: 20190091147Abstract: Disclosed is a preparation method for charge reversal and reversibly crosslinked redox-sensitive nanomicelles, falling within the technical field of biomedical materials. The method comprises: synthesizing thiocinamide from lipoic acid and ethylenediamine under an N,N?-carbonyl diimidazole catalyst; and polymerizing thiocinamide, polyethylene glycol diglycidyl ether and lysine through a nucleophilic addition mechanism to prepare a poly(lysine-co-polyethylene glycol diglycidyl ether-co-thiocinamide) terpolymer. The micelle is endowed with excellent anti-protein nonspecific adsorption and enhanced cell uptake property through a self-assembly and protonation/deprotonation action; and a disulfide bond in lipoyl may form a linear polydisulfide structure under the action of 1,4-dithiothreitol, so that a micelle core is crosslinked, and a crosslinked structure is destroyed in the cell under a redox condition, and controlled release of a drug can be achieved.Type: ApplicationFiled: April 27, 2017Publication date: March 28, 2019Inventors: Liping ZHANG, Ren LIU, Caihua NI, Yuanyuan Ding, Gang SHI, Xinxin Sang