Patents by Inventor Xinxu Shi

Xinxu Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of progesterone receptor modulators
    Patent number: 7754895
    Abstract: Processes for preparing oxindoles, which can be utilized in the preparation of a variety of useful compounds, and methods for minimizing or preventing N-alkylation of amide containing compounds, including oxindoles, are provided.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: July 13, 2010
    Assignee: Wyeth LLC
    Inventors: Yanzhong Wu, Bogdan Kazimierz Wilk, Zhixian Ding, Xinxu Shi, Charles Chao Wu, Panolil Raveendranath, Haris Durutlic
  • N'-(2-HALOBENZYLIDENE)SULFONYLHYDRAZIDES AS INTERMEDIATES IN THE MANUFACTURE OF ARYLSULFONYLINDAZOLES
    Publication number: 20090023925
    Abstract: The present invention provides N?-(2-halobenzylidene)sulfonylhydrazides of formula I Compounds of formula I are useful for the manufacture of 1-arylsulfonylindazole 5-HT6 ligands.
    Type: Application
    Filed: June 27, 2008
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: Anita Wai-Yin Chan, Mahmut Levent, David Place, Panolil Raveendranath, Sanjay Raveendranth, Vijay Raveendranath, Girija Raveendranath, Xinxu Shi, Charles Wu
  • PROCESS FOR THE PREPARATION OF TRIFLUOROALKYL-PHENYL AND HETEROCYCLIC SULFONAMIDES
    Publication number: 20090023903
    Abstract: A novel trifluoroacetylating agent, i.e., N-trifluoroacetylmorpholine, is described. This reagent is useful in the preparation of phenyl and heterocyclic sulfonamide compounds. Methods are therefore described for preparing sulfonamide compounds of the following structure, wherein R1 and R2 are defined herein, using N-trifluoroacetylmorpholine. The sulfonamide compounds that may be prepared as described herein include 5-chloro-thiophene-2-sulfonic acid [(1S,2R)-2-(3,5-difluoro-phenyl)-3,3,3-trifluoro-1-hydroxymethyl-propyl]-amide using N-trifluoroacetylmorpholine.
    Type: Application
    Filed: July 14, 2008
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: Terrence Joseph Connolly, Anita Wai-Yin Chan, Zhixian Ding, Mousumi Ghosh, Xinxu Shi, Jianxin Ren, Eric Hansen, Roger Farr, Michael MacEwan, Asaf Alimardanov, Antonia Nikitenko, John Potoski
  • Methods for the Preparation of {2-[(8,9)-Dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} Phosphonic Acid and Esters Thereof
    Publication number: 20080114165
    Abstract: The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid, and esters thereof.
    Type: Application
    Filed: January 18, 2008
    Publication date: May 15, 2008
    Applicant: WYETH
    Inventors: Bogdan WILK, Galina VID, Weiguo LIU, Xinxu SHI
  • PROCESSES AND COMPOUNDS FOR THE PREPARATION OF SUBSTITUTED NAPHTHYLINDOLE DERIVATIVES
    Publication number: 20080071091
    Abstract: The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1 (PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.
    Type: Application
    Filed: November 28, 2007
    Publication date: March 20, 2008
    Applicant: Wyeth
    Inventors: Vladimir DRAGAN, John Potoski, Wayne McMahon, Jean Helom, Xinxu Shi
  • Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid and esters thereof
    Patent number: 7345032
    Abstract: The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid, and esters thereof.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: March 18, 2008
    Assignee: Wyeth
    Inventors: Bogdan K. Wilk, Galina Vid, Weiguo Liu, Xinxu Shi
  • Processes and compounds for the preparation of substituted naphthylindole derivatives
    Patent number: 7323483
    Abstract: The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: January 29, 2008
    Assignee: Wyeth
    Inventors: Vladimir A. Dragan, John Richard Potoski, Wayne G. McMahon, Jean Louise Helom, Xinxu Shi
  • Process for the synthesis of progesterone receptor modulators
    Publication number: 20070027327
    Abstract: Processes for preparing oxindoles, which can be utilized in the preparation of a variety of useful compounds, and methods for minimizing or preventing N-alkylation of amide containing compounds, including oxindoles, are provided.
    Type: Application
    Filed: July 27, 2006
    Publication date: February 1, 2007
    Applicant: Wyeth
    Inventors: Yanzhong Wu, Bogdan Wilk, Zhixian Ding, Xinxu Shi, Charles Wu, Panolil Raveendranath, Haris Durutlic
  • Processes and compounds for the preparation of substituted naphthylindole derivatives
    Publication number: 20060183917
    Abstract: The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.
    Type: Application
    Filed: January 25, 2006
    Publication date: August 17, 2006
    Applicant: Wyeth
    Inventors: Vladimir Dragan, John Potoski, Wayne McMahon, Jean Helom, Xinxu Shi
  • Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl[ethyl} phosphonic acid and esters thereof
    Publication number: 20050090470
    Abstract: The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1 (7)-en-2-yl]ethyl}phosphonic acid, and esters thereof.
    Type: Application
    Filed: October 20, 2004
    Publication date: April 28, 2005
    Applicant: Wyeth
    Inventors: Bogdan Wilk, Galina Vid, Weiguo Liu, Xinxu Shi