Patents by Inventor XinYan Zhang
XinYan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141347Abstract: An RNA delivery system for the treatment of Huntington's disease. The system comprises a viral vector, the viral vector carries RNA fragments capable of treating Huntington's disease, the viral vector is capable of enrichment in organ tissues of a host and endogenously and spontaneously forming a complex containing the RNA fragments capable of treating Huntington's disease in the organ tissues of the host, and the complex can deliver the RNA fragments into a target tissue to treat Huntington's disease. The safety and reliability of the RNA delivery system for the treatment of Huntington's disease have been fully verified. The system has good medicinal properties, strong versatility, and has economic benefits and application prospects.Type: ApplicationFiled: September 28, 2023Publication date: May 2, 2024Inventors: Chenyu ZHANG, Xi CHEN, Zheng FU, Jing LI, Xiang ZHANG, Xinyan ZHOU, Li ZHANG, Mengchao YU, Hongyuan GUO
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Publication number: 20240141361Abstract: Provided are a gene circuit, an RNA delivery system and the use thereof. Specifically, the gene circuit comprises at least an RNA fragment capable of inhibiting gene expression and/or a targeting tag having a targeting function. The gene circuit can be delivered to a host, enriched in organ tissues of the host and self-assembled to form a complex structure, and inhibits gene expression by means of the RNA fragment, thereby treating diseases. The delivery system comprises the gene circuit and a delivery carrier capable of delivering the gene circuit to organ tissues of a host for enrichment. The provided gene circuit has a targeting function and a treatment function, can quickly and accurately reach target organs and target tissues to exert a treatment effect, and is highly efficient with good results. The safety and reliability of the provided RNA delivery system are fully verified, and the RNA delivery system has good druggability, high universality, and great economic benefits and application prospects.Type: ApplicationFiled: September 28, 2023Publication date: May 2, 2024Inventors: Chenyu Zhang, Xi Chen, Zheng Fu, Jing Li, Xiang Zhang, Xinyan Zhou, Li Zhang, Mengchao Yu, Hongyuan Guo
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Publication number: 20240141344Abstract: Provided are an RNA plasmid delivery system and an application thereof. The RNA plasmid delivery system comprises a plasmid carrying an RNA fragment required to be delivered; the plasmid can be enriched in an organ tissue of a host, and spontaneously forms an exosome containing the RNA fragment in the organ tissue of the host, and therefore can enter and be combined with a target tissue to deliver the RNA fragment into the target tissue. The RNA delivery system is safe, reliable, good in druggability, and strong in universality.Type: ApplicationFiled: September 28, 2023Publication date: May 2, 2024Inventors: Chenyu Zhang, Xi Chen, Zheng Fu, Jing Li, Xiang Zhang, Xinyan Zhou, Li Zhang, Mengchao Yu, Hongyuan Guo
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Publication number: 20240141380Abstract: Provided are a viral vector-based RNA delivery system and a use thereof. The RNA delivery system comprises a viral vector. The viral vector carries an RNA fragment needing to be delivered, and can be enriched in organ tissues of a host. In the host organ tissues, the viral vector can endogenously and spontaneously form a composite structure containing the RNA fragment. The composite structure can enter and bind to target tissues, and feed the RNA fragment into the target tissues. The viral vector has a targeting tag. The composite structure is an exosome. The viral vector RNA delivery system is safe and reliable, and has good druggability and high universality.Type: ApplicationFiled: September 28, 2023Publication date: May 2, 2024Inventors: Chenyu Zhang, Xi Chen, Zheng Fu, Jing Li, Xiang Zhang, Xinyan Zhou, Li Zhang, Mengchao Yu, Hongyuan Guo
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Patent number: 11959122Abstract: A method for assessing microbial drug resistance multi-level risks of antibiotic residues in water environments, belonging to the technical field of water environment assessment, comprises the following steps: S1, environment monitoring; S2, preliminary screening of antibiotics: S2-1, determination of n-octanol/water partition coefficient, and S2-2, determination of antibiotic environment concentration; S3, assessment of microbial drug resistance; and S4, high-level assessment. The assessment method of the present disclosure conducts a step-by-step assessment of target antibiotics or target antibiotic derivatives in water environment with risks.Type: GrantFiled: May 27, 2023Date of Patent: April 16, 2024Assignees: NANJING INSTITUTE OF ENVIRONMENTAL SCIENCES, MEE, NANJING UNIVERSITYInventors: Xinyan Guo, Na Wang, Qingbin Yuan, Ni Ni, Xiaohui Zhang, Mali Shi, Jingbiao Li
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Publication number: 20240087491Abstract: This application is applicable to the field of intelligent vehicles, and specifically provides a projection method and apparatus, a vehicle, and an AR-HUD. The projection method includes: obtaining image information and position information of a calibration object; projecting the calibration object based on the image information and the position information of the calibration object and an imaging model; and when an overlap ratio between the calibration object and a projection plane of the calibration object is less than a first threshold, adjusting a parameter of the imaging model. According to this application, an image projected and displayed may be aligned with a real world, which improves a projection display effect.Type: ApplicationFiled: November 16, 2023Publication date: March 14, 2024Inventors: Xinyan Jiang, Yuteng Zhang, Hai Yu
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Publication number: 20240088869Abstract: A frequency-tunable film bulk acoustic resonator and a preparation method therefor are provided. The resonator includes a substrate, an air gap, a sandwiched structure formed by electrodes and piezoelectric layers, and an electrode lead-out layer, wherein the substrate is connected to the sandwiched structure formed by the electrodes and the piezoelectric layers, and a connection face of the substrate and the sandwiched structure formed by the electrodes and the piezoelectric layers is recessed towards inside of the substrate to form the air gap; and the electrode lead-out layer is connected to the sandwiched structure formed by the electrodes and the piezoelectric layers. The sandwiched structure formed by the electrodes and the piezoelectric layers includes a bottom electrode, piezoelectric layers, intermediate electrodes, and a top electrode, wherein the electrodes and the piezoelectric layers are alternately arranged to form the sandwiched structure.Type: ApplicationFiled: October 31, 2021Publication date: March 14, 2024Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGYInventors: Guoqiang LI, Tielin ZHANG, Hongbin LIU, Xinyan YI, Lishuai ZHAO, Peidong OUYANG
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Patent number: 10988397Abstract: The present invention discloses a small integrated greening device and method for recycling wastewater, including a wastewater collection system, a microorganism and plant purification system, and a reclaimed water collection and distribution system. The method includes the following process: greywater or wastewater is collected through a pipeline and enters a water collection tank of a wastewater collection part. Lifting is performed by submersible sewage pumps, such that the lifted water enters a microorganism and plant synergistic purification and greening part. Each submersible pump is controlled by one corresponding automatic water level controller to transport the treated water to the reclaimed water-use sites.Type: GrantFiled: January 21, 2020Date of Patent: April 27, 2021Assignee: XI'AN UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Qiong Wan, Zhiyan Li, Xuhui Zhou, Li Zhang, Liu Yu, Kai Wang, Tiening Xue, Xinyan Zhang, Kai Ju, Shuancheng Gu
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Patent number: 10942814Abstract: In an embodiment, described herein is a system and method for discovering backups of a database running on a database host, for use by a centralized backup system to validate backup compliance. A report agent executing on the database host can implement a discovery process configured to gather metadata for the backups of the database from a number of dynamic performance views of the database. The metadata is recorded in a control file of the database, and can include one or more commands used by the backup tool to create the backups. The report agent can categorize the metadata into one or more groups based on the backup commands, map backup files associated with each backup to that backup, create a backup report to describe the mapping information and additional information for each backup, and send the backup report to the centralized backup system.Type: GrantFiled: July 31, 2018Date of Patent: March 9, 2021Assignee: EMC IP HOLDING COMPANY LLCInventors: Wei Chu, Xinyan Zhang, Kenneth Owens, Adrian Dobrean, Daniel Wolski
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Publication number: 20200239345Abstract: The present invention discloses a small integrated greening device and method for recycling wastewater, including a wastewater collection system, a microorganism and plant purification system, and a reclaimed water collection and distribution system. The method includes the following process: greywater or wastewater is collected through a pipeline and enters a water collection tank of a wastewater collection part. Lifting is performed by submersible sewage pumps, such that the lifted water enters a microorganism and plant synergistic purification and greening part. Each submersible pump is controlled by one corresponding automatic water level controller to transport the treated water to the reclaimed water-use sites.Type: ApplicationFiled: January 21, 2020Publication date: July 30, 2020Inventors: Qiong WAN, Zhiyan LI, Xuhui ZHOU, Li ZHANG, Liu YU, Kai WANG, Tiening XUE, Xinyan ZHANG, Kai JU, Shuancheng GU
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Publication number: 20200180174Abstract: A multipurpose vehicular emergency tool has a power source and a plurality of electrical outputs sufficient to act as a jump-starter for a vehicle or to charge mobile electronic devices, in addition to powering a light source to act as a flashlight. A plurality of emergency tools are provided, including a seatbelt cutter and a window breaker, in order to facilitate one's safety and survival in an emergency vehicular situation. Additional features include an emergency flasher light, a plurality of reflective bands, a compass, an emergency alarm, and a thermometer.Type: ApplicationFiled: October 9, 2019Publication date: June 11, 2020Inventor: Xinyan Zhang
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Publication number: 20200042395Abstract: In an embodiment, described herein is a system and method for discovering backups of a database running on a database host, for use by a centralized backup system to validate backup compliance. A report agent executing on the database host can implement a discovery process configured to gather metadata for the backups of the database from a number of dynamic performance views of the database. The metadata is recorded in a control file of the database, and can include one or more commands used by the backup tool to create the backups. The report agent can categorize the metadata into one or more groups based on the backup commands, map backup files associated with each backup to that backup, create a backup report to describe the mapping information and additional information for each backup, and send the backup report to the centralized backup system.Type: ApplicationFiled: July 31, 2018Publication date: February 6, 2020Inventors: Wei CHU, Xinyan ZHANG, Kenneth OWENS, Adrian DOBREAN, Daniel WOLSKI
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Patent number: 10281405Abstract: Described is an elemental analysis system and methods for use thereof that can be utilized in examination of samples in their native state. The systems utilize a liquid sampling—atmospheric pressure glow discharge (LS-APGD) device for ambient desorption sampling and excitation of a solid sample in combination with optical emission detection. This approach can find application across a broad spectrum of analytical challenges including metals, soils, and volume-limited samples.Type: GrantFiled: January 6, 2017Date of Patent: May 7, 2019Assignee: Clemson University Research FoundationInventors: Richard Kenneth Marcus, Htoo Wai Paing, Xinyan Zhang
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Publication number: 20170199130Abstract: Described is an elemental analysis system and methods for use thereof that can be utilized in examination of samples in their native state. The systems utilize a liquid sampling—atmospheric pressure glow discharge (LS-APGD) device for ambient desorption sampling and excitation of a solid sample in combination with optical emission detection. This approach can find application across a broad spectrum of analytical challenges including metals, soils, and volume-limited samples.Type: ApplicationFiled: January 6, 2017Publication date: July 13, 2017Inventors: Richard Kenneth Marcus, Htoo Wai Paing, Xinyan Zhang
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Patent number: 8775655Abstract: One embodiment provides a system and a method for presenting streaming media content delivered through a peer-to-peer overlay network. During operation, a data-transfer mechanism sends requests to a plurality of peer nodes to receive data for streaming media content. The system stores received data for the streaming media content into a buffer. Next, a server local to a media presentation mechanism serves the buffered data to a media presentation mechanism. The server controls the data serving in response to a signal received from the media-presentation mechanism.Type: GrantFiled: October 21, 2005Date of Patent: July 8, 2014Assignee: Roxbeam Media Network CorporationInventor: Xinyan Zhang
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Patent number: 8712883Abstract: A system and method facilitate dynamic QoS-based billing in a P2P network. According to one embodiment, a peer node identifies a plurality of partner peer nodes that transiently stage streaming media data the peer node requests and receives from the partner peer nodes. The peer node further collects QoS information for the received data and communicates a QoS information report to a remote node to facilitate QoS-based billing.Type: GrantFiled: June 12, 2006Date of Patent: April 29, 2014Assignee: Roxbeam Media Network CorporationInventors: Yongqi Yang, Xinyan Zhang
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Publication number: 20120011200Abstract: One embodiment of the present invention provides a peer-to-peer (P2P) data-storage system. The system includes a P2P network, a file upload module configured to receive a file uploaded by a user, a file processing module configured to disassemble the received file into a plurality of file blocks and select a plurality of peer nodes from the P2P network, and a file distribution module configured to distribute the file blocks to the selected peer nodes. A respective file block is distributed to a respective peer node.Type: ApplicationFiled: July 5, 2011Publication date: January 12, 2012Applicant: ROXBEAM MEDIA NETWORK CORPORATIONInventors: Xinyan Zhang, Li Zhou
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Patent number: 7937362Abstract: A system and method facilitate a credit system for providing user incentives to encourage data sharing in a P2P network. The credit system maintains a user credit database and respectively increases or decreases a user's credits based on the data uploaded to or downloaded from other peer nodes. The credit system can also associate a user's credits with economic value or rewards to encourage the user to share data with other peer nodes. In one embodiment, the credit system maintains a credit record for each user. The credit system increases the credit for a user based on the amount of data a peer node associated with the user uploads to other peer nodes in the P2P network. The credit system also decreases the credit for the user based on the amount of data downloaded by the peer node associated with the user.Type: GrantFiled: April 28, 2006Date of Patent: May 3, 2011Assignee: Roxbeam Media Network CorporationInventors: Qiao Lian, Xinyan Zhang
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Patent number: 7818402Abstract: One embodiment provides a method and a system for expediting content delivery in a peer-to-peer overlay network. A local cache and directory server caches a multiplicity of segments for multi-media content, and maintains a mapping between cacheable content and one or more local partner nodes that transiently stage segments for the cacheable content. The local cache and directory server receives a request identifying requested content, which may or may not be cached or mapped. The cache and directory server determines a match to the requested content in the mapping and sends a list of local partner nodes that transiently stage segments for the requested content based on the match.Type: GrantFiled: February 8, 2006Date of Patent: October 19, 2010Assignee: Roxbeam Media Network CorporationInventor: Xinyan Zhang
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Patent number: 7742485Abstract: A system for delivering streamed content over a large digital network such as the Internet. Distributed functionality executes on nodes in the network to achieve functions such as assigning partner nodes for transfer of content to or from a target node, scheduling transfer operations among nodes, adding or removing nodes from the network, maintaining security, and other operations. Different embodiments may use one or more of the functional features. In a preferred embodiment, video content is segmented and streamed through multi-path routing. An overlay network uses nodes in partnership groups so that a target node can obtain segments from multiple sources. Partner nodes can provide the segments within a given time window, including simultaneous delivery from multiple partner nodes, so that a more reliable data stream is supported.Type: GrantFiled: July 29, 2005Date of Patent: June 22, 2010Assignee: Roxbeam Media Network CorporationInventor: Xinyan Zhang