Patents by Inventor Xinyao Du

Xinyao Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPIDS FOR LIPID NANOPARTICLE DELIVERY OF ACTIVE AGENTS
    Publication number: 20250236586
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, G1, G2, and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: September 30, 2024
    Publication date: July 24, 2025
    Inventor: Xinyao Du
  • LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20250188020
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: September 16, 2024
    Publication date: June 12, 2025
    Inventors: Xinyao Du, Steven M. Ansell, Jason Samuel Tan, Polina Blagojevic, Stephen Paul Arns, Julia Gatenyo
  • LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20250084030
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: July 9, 2024
    Publication date: March 13, 2025
    Inventor: Xinyao DU
  • LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20250084029
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: May 10, 2024
    Publication date: March 13, 2025
    Inventor: Xinyao Du
  • CATIONIC LIPIDS FOR USE IN LIPID NANOPARTICLES
    Publication number: 20250059129
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein a, b, c, d, G1, G2, L1, L2, R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8 and X are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, nanoparticles comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: March 21, 2024
    Publication date: February 20, 2025
    Inventors: Julia Gatenyo, Xinyao Du
  • NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20250034081
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: April 18, 2024
    Publication date: January 30, 2025
    Inventors: Steven M. Ansell, Xinyao Du
  • MIXED AMIDE ESTER CONTAINING LIPIDS FOR USE IN LIPID NANOPARTICLES
    Publication number: 20250025427
    Abstract: Compounds are provided having the following Formula (I): or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein G1, G2, R1, R2, R3, L1a, L1b, and L2 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: June 14, 2024
    Publication date: January 23, 2025
    Inventors: Xinyao Du, Polina Blagojevic, Stephen Paul Arns
  • Lipids for lipid nanoparticle delivery of active agents
    Patent number: 12151996
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, G1, G2, and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: November 26, 2024
    Assignee: Acuitas Therapeutics, Inc.
    Inventor: Xinyao Du
  • Lipids for use in lipid nanoparticle formulations
    Patent number: 12129223
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: October 29, 2024
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Xinyao Du, Steven M. Ansell, Jason Samuel Tan, Polina Blagojevic, Stephen Paul Arns, Julia Gatenyo
  • LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20240308952
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: November 30, 2023
    Publication date: September 19, 2024
    Inventor: Xinyao Du
  • Lipids for use in lipid nanoparticle formulations
    Patent number: 12065396
    Abstract: Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: August 20, 2024
    Assignee: Acuitas Therapeutics, Inc.
    Inventor: Xinyao Du
  • LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20240270679
    Abstract: Compounds are provided having the following Structure (I): or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R1a, R1b, R2, R3, L1a, L1b, n1, and X are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: September 6, 2023
    Publication date: August 15, 2024
    Inventors: Xinyao Du, Polina Blagojevic, Elena Barbosa
  • Cationic lipids for use in lipid nanoparticles
    Patent number: 11976019
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein a, b, c, d, G1, G2, L1, L2, R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8 and X are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, nanoparticles comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: May 7, 2024
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Julia Gatenyo, Xinyao Du
  • NOVEL CARBONYL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20240122854
    Abstract: Compounds are provided having one of the following structures (I) or or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G1b and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: October 6, 2023
    Publication date: April 18, 2024
    Inventors: Xinyao Du, Steven M. Ansell
  • NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20240075163
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: October 24, 2023
    Publication date: March 7, 2024
    Inventors: Steven M. Ansell, Xinyao Du
  • LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20230372537
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Application
    Filed: June 9, 2023
    Publication date: November 23, 2023
    Inventors: Michael J. Hope, Barbara Mui, Paulo Jia Ching Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • Carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11820728
    Abstract: Compounds are provided having one of the following structures (I) or (II): or (I) (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G2b and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: November 21, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Xinyao Du, Steven M. Ansell
  • LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20230295075
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: December 15, 2022
    Publication date: September 21, 2023
    Inventors: Xinyao Du, Steven M. Ansell, Jason Samuel Tan, Polina Blagojevic, Stephen Paul Arns, Julia Gatenyo
  • Lipid nanoparticle formulations
    Patent number: 11712481
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: August 1, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Michael J. Hope, Barbara Mui, Paulo Jia Ching Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11648324
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: May 16, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du