Abstract: A method and a device for time synchronization are disclosed according to the embodiments of the present invention. The method includes: selecting, by a slave device, a port of a single-fiber bi-directional line as a synchronization port of a 1588 clock protocol; specifying a work mode of the synchronization port; exchanging a 1588 clock synchronization packet with a master device through the synchronization port according to the work mode; acquiring transmission time information and restore a system clock according to the 1588 clock synchronization packet; and adjusting the system clock according to the work mode and the transmission time information. The device includes: a line processing module, a clock recovery module and a clock adjustment module. Through the method and the device, zero-error time synchronization is implemented; and in the case of unfixed path delay, the time synchronization can also be implemented.

Abstract: The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.