Patents by Inventor Xinzhong Dong

Xinzhong Dong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING MELANOMA
    Publication number: 20240337646
    Abstract: Compositions and methods are provided that include use of one or more MrgprX4 antagonists to treat melanoma.
    Type: Application
    Filed: July 29, 2022
    Publication date: October 10, 2024
    Inventors: Xinzhong Dong, Naina Gour
  • COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN
    Publication number: 20240002395
    Abstract: Positive allosteric modulators (PAMs) of Mas-related G protein-coupled receptor X1 (MRGPRX1) and their use for treating neuropathic pain is disclosed.
    Type: Application
    Filed: November 30, 2021
    Publication date: January 4, 2024
    Inventors: Takashi Tsukamoto, Barbara Slusher, Nlyada Hin, Camilo Rojas, Xinzhong Dong, Yun Guan, Ilyas Abdul-Quddoos Berhane
  • COMPOSITIONS AND METHODS FOR TREATING G PROTEIN COUPLED RECEPTOR MEDIATED CONDITIONS
    Publication number: 20230228738
    Abstract: The present invention relates to cells and methods for detecting compounds that affect G protein coupled receptor mediated conditions. The invention also relates to methods for treating adverse drug reactions, autoimmune disorders, and pruritus.
    Type: Application
    Filed: June 27, 2022
    Publication date: July 20, 2023
    Inventors: Xinzhong Dong, Chirag Vasavda, Solomon H. Snyder, James Meixiong, Yingying Cheng, Nathachit Limjunyawong, Xintong Dong
  • Method for treating a chronic itch condition by administering small molecule MrgprX4 antagonists
    Patent number: 11442059
    Abstract: The present invention relates to cells and methods for detecting compounds that affect G protein coupled receptor mediated conditions. The invention also relates to methods for treating adverse drug reactions, autoimmune disorders, and pruritus.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: September 13, 2022
    Assignee: The Johns Hopkins University
    Inventors: Xinzhong Dong, Chirag Vasavda, Solomon H. Snyder, James Meixiong, Yingying Cheng, Nathachit Limjunyawong, Xintong Dong
  • TMEM100 PEPTIDES AND VARIANTS THEREOF AND THEIR USE IN TREATING OR PREVENTING DISEASES OR CONDITIONS
    Publication number: 20210403526
    Abstract: The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.
    Type: Application
    Filed: July 6, 2021
    Publication date: December 30, 2021
    Inventors: Xinzhong Dong, Hao-jui Weng
  • Tmem100 peptides and variants thereof and their use in treating or preventing diseases or conditions
    Patent number: 11066455
    Abstract: The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Xinzhong Dong, Hao-Jui Weng
  • MRGPRX2/MRGPRB2 EXPRESSING CELL BASED ASSAY TO DETECT PSEUDO-ALLERGIC DRUG REACTIONS AND TO IDENTIFY BLOCKERS TO PREVENT THE ADVERSE REACTIONS
    Publication number: 20200370051
    Abstract: The present invention relates to cells and methods for detecting compounds that induce a pseudo-allergic-type reaction and methods for reducing the severity of a pseudo-allergic-type reaction.
    Type: Application
    Filed: June 5, 2020
    Publication date: November 26, 2020
    Inventors: Xinzhong Dong, Benjamin McNeil
  • MrgprX2/MrgprB2 expressing cell based assay to detect pseudo-allergic drug reactions and to identify blockers to prevent the adverse reactions
    Patent number: 10696971
    Abstract: The present invention relates to cells and methods for detecting compounds that induce a pseudo-allergic-type reaction and methods for reducing the severity of a pseudo-allergic-type reaction.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: June 30, 2020
    Assignee: The Johns Hopkins University
    Inventors: Xinzhong Dong, Benjamin McNeil
  • COMPOSITIONS AND METHODS FOR TREATING G PROTEIN COUPLED RECEPTOR MEDIATED CONDITIONS
    Publication number: 20200173985
    Abstract: The present invention relates to cells and methods for detecting compounds that affect G protein coupled receptor mediated conditions. The invention also relates to methods for treating adverse drug reactions, autoimmune disorders, and pruritus.
    Type: Application
    Filed: June 15, 2018
    Publication date: June 4, 2020
    Inventors: Xinzhong Dong, Chirag Vasavda, Solomon H. Snyder, James Meixiong, Yingying Cheng, Nathachit Limjunyawong, Xintong Dong
  • METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS
    Publication number: 20170355997
    Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
    Type: Application
    Filed: August 21, 2017
    Publication date: December 14, 2017
    Inventors: Xinzhong Dong, Qin Liu, David J. Anderson
  • TMEM100 PEPTIDES AND VARIANTS THEREOF AND THEIR USE IN TREATING OR PREVENTING DISEASES OR CONDITIONS
    Publication number: 20170305990
    Abstract: The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.
    Type: Application
    Filed: February 20, 2015
    Publication date: October 26, 2017
    Inventors: Xinzhong Dong, Hao-Jui Weng
  • Methods and compositions for treating or preventing pruritis
    Patent number: 9771592
    Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: September 26, 2017
    Assignees: The Johns Hopkins University, California Institute of Technology
    Inventors: Xinzhong Dong, Qin Liu, David J. Anderson
  • MRGPRX2/MRGPRB2 EXPRESSING CELL BASED ASSAY TO DETECT PSEUDO-ALLERGIC DRUG REACTIONS AND TO IDENTIFY BLOCKERS TO PREVENT THE ADVERSE REACTIONS
    Publication number: 20170204419
    Abstract: The present invention relates to cells and methods for detecting compounds that induce a pseudo-allergic-type reaction and methods for reducing the severity of a pseudo-allergic-type reaction.
    Type: Application
    Filed: July 31, 2015
    Publication date: July 20, 2017
    Inventors: Xinzhong Dong, Benjamin Mcneil
  • Pain signaling molecules
    Patent number: 8916355
    Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: December 23, 2014
    Assignee: California Institute of Technology
    Inventors: David J. Anderson, Xinzhong Dong, Mark Zylka, Sang-kyou Han, Melvin I. Simon
  • METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS
    Publication number: 20140303231
    Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
    Type: Application
    Filed: January 24, 2014
    Publication date: October 9, 2014
    Applicant: The Johns Hopkins University
    Inventors: Xinzhong Dong, Qin Liu, David J. Anderson
  • METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS
    Publication number: 20120073001
    Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
    Type: Application
    Filed: November 30, 2009
    Publication date: March 22, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Xinzhong Dong, Qin Liu, David J. Anderson
  • IDENTIFICATION AND USE OF COMPOUNDS FOR TREATING PERSISTENT PAIN
    Publication number: 20110150769
    Abstract: The present application provides methods and compositions that can be used to treat persistent pain and to identify compounds that can be used for treating persistent pain. More specifically, agonists of members of the Mrgpr receptor family, particularly agonists of MrgprX1, can identified and screened for use in treating persistent pain, such as pain caused by inflammation or nerve injury.
    Type: Application
    Filed: August 5, 2010
    Publication date: June 23, 2011
    Inventors: David J. Anderson, Xinzhong Dong, Qin Liu, Yun Guan
  • MRG polypeptides and nucleic acids encoding the same
    Patent number: 7691604
    Abstract: The invention relates generally to novel genes expressed in normal but not neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: April 6, 2010
    Assignee: California Institute of Technology
    Inventors: Xinzhong Dong, David J. Anderson
  • Assay employing G protein-coupled receptor expressed in dorsal root ganglia
    Patent number: 7510845
    Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: March 31, 2009
    Assignee: California Institute of Technology
    Inventors: David J. Anderson, Xinzhong Dong, Mark J. Zylka, Sang-Kyou Han, Melvin I. Simon
  • IDENTIFICATION OF A RECEPTOR CONTROLLING MIGRATION AND METASTASIS OF SKIN CANCER CELLS
    Publication number: 20080014586
    Abstract: The invention relates generally to genes expressed in skin cancer cells, particularly melanoma tumor cells, and their role in migration and metastasis. Methods for identifying melanoma cells are provided, as are methods of treating melanoma. Methods for identifying compounds that are useful in the treatment of melanoma are also provided.
    Type: Application
    Filed: July 13, 2007
    Publication date: January 17, 2008
    Applicant: California Institute of Technology
    Inventors: Mark Zylka, Xinzhong Dong, David Anderson