Patents by Inventor Xinzhu Gu

Xinzhu Gu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220160526
    Abstract: The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices include a combination or integration of superelastic material, biodegradable metal and, thin film nitinol and/or biodegradable polymer. A structural frame is formed of individual elongated pieces composed of biodegradable metal. These pieces are joined together by connector pieces composed of superelastic material. At least a portion of the structural frame has deposited thereon the thin film nitinol and/or biodegradable polymer. The structural frame of the device is collapsible for insertion in a delivery tube and, recoverable for deployment and placement in a vascular location of a patient body.
    Type: Application
    Filed: December 2, 2020
    Publication date: May 26, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: YOUNGJAE CHUN, WILLIAM R. WAGNER, XINZHU GU, PETER DREW WEARDEN, TOMO YOSHIZUMI
  • Patent number: 10888442
    Abstract: The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices include a combination or integration of superelastic material, biodegradable metal and, thin film nitinol and/or biodegradable polymer. A structural frame is formed of individual elongated pieces composed of biodegradable metal. These pieces are joined together by connector pieces composed of superelastic material. At least a portion of the structural frame has deposited thereon the thin film nitinol and/or biodegradable polymer. The structural frame of the device is collapsible for insertion in a delivery tube and, recoverable for deployment and placement in a vascular location of a patient body.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: January 12, 2021
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Youngjae Chun, William R. Wagner, Xinzhu Gu, Peter Drew Wearden, Tomo Yoshizumi
  • Patent number: 10744308
    Abstract: The invention relates to an in-utero ventriculoamniotic shunting device that includes a shunt tube (26) composed of polymer composite and having metallic wire embedded therein, one or more anchors (30) composed of superelastic wire, e.g., thermal shape-set nitinol structures, that are mechanically attached to an exterior surface of the shunt tube (26), and a one-way passive valve (32) composed of a thin polymer membrane. The anchors (30) are effective to prevent migration and dislodgement of the shunting device following its deployment, and the valve (32) is effective to prevent the backflow of amniotic fluid (23).
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: August 18, 2020
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Yanfei Chen, Young Jae Chun, Stephen Emery, Xinzhu Gu, William Wagner, Stephanie Greene
  • Patent number: 10336911
    Abstract: A waterborne shape memory polymer coating that gives textiles and fibers good shape memory performance. An amphiphilic, crosslinkable grafted polysaccharide polymer was synthesized and provided in a water dispersion that can be applied to a flexible fibrous material and then crosslinked to yield good shape memory properties. The polymer coating showed good binding to human hair, which could be styled into a permanent shape (e.g., straight) during the crosslinked step. Next, this permanent shape can be styled to a temporary shape (e.g. curly) by heating and styling, and cooling. Finally, the permanent style can be regained by activation with water, heat, or both.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 2, 2019
    Assignee: Syracuse University
    Inventors: Patrick T. Mather, Xinzhu Gu
  • Publication number: 20180369160
    Abstract: Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided.
    Type: Application
    Filed: June 18, 2018
    Publication date: December 27, 2018
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Kia M. Washington, William R. Wagner, Michael Brandt Steketee, Yolandi Van der Merwe, Xinzhu Gu
  • Publication number: 20180296810
    Abstract: The invention relates to an in-utero ventriculoamniotic shunting device that includes a shunt tube (26) composed of polymer composite and having metallic wire embedded therein, one or more anchors (30) composed of superelastic wire, e.g., thermal shape-set nitinol structures, that are mechanically attached to an exterior surface of the shunt tube (26), and a one-way passive valve (32) composed of a thin polymer membrane. The anchors (30) are effective to prevent migration and dislodgement of the shunting device following its deployment, and the valve (32) is effective to prevent the backflow of amniotic fluid (23).
    Type: Application
    Filed: October 13, 2016
    Publication date: October 18, 2018
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Yanfei Chen, Young Jae Chun, Stephen Emery, Xinzhu Gu, William Wagner, Stephanie Greene
  • Publication number: 20170340463
    Abstract: The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices include a combination or integration of superelastic material, biodegradable metal and, thin film nitinol and/or biodegradable polymer. A structural frame is formed of individual elongated pieces composed of biodegradable metal. These pieces are joined together by connector pieces composed of superelastic material. At least a portion of the structural frame has deposited thereon the thin film nitinol and/or biodegradable polymer. The structural frame of the device is collapsible for insertion in a delivery tube and, recoverable for deployment and placement in a vascular location of a patient body.
    Type: Application
    Filed: November 11, 2015
    Publication date: November 30, 2017
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: YOUNGJAE CHUN, WILLIAM R. WAGNER, XINZHU GU, PETER DREW WEARDEN, TOMO YOSHIZUMI
  • Publication number: 20160032140
    Abstract: A waterborne shape memory polymer coating that gives textiles and fibers good shape memory performance. An amphiphilic, crosslinkable grafted polysaccharide polymer was synthesized and provided in a water dispersion that can be applied to a flexible fibrous material and then crosslinked to yield good shape memory properties. The polymer coating showed good binding to human hair, which could be styled into a permanent shape (e.g., straight) during the crosslinked step. Next, this permanent shape can be styled to a temporary shape (e.g. curly) by heating and styling, and cooling. Finally, the permanent style can be regained by activation with water, heat, or both.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: Syracuse University
    Inventors: Patrick T. MATHER, Xinzhu GU
  • Patent number: 9249254
    Abstract: A multi-block thermoplastic polyurethanes system which incorporates polyhedral oligomeric silsesquioxane into conventional biodegradable thermoplastic polyurethanes built up by poly(?-caproactone) and polyethylene glycol blocks, resulting in biostability. The multi-block thermoplastic polyurethanes are synthesized from lysine-diisocyanate with poly(?-caprolactone)-diol, polyhedral oligomeric silsesquioxane-diol, and poly(ethylene glycol) using a one-step synthesis process.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: February 2, 2016
    Assignee: Syracuse University
    Inventors: Patrick Mather, Jian Wu, Xinzhu Gu
  • Publication number: 20110263808
    Abstract: A multi-block thermoplastic polyurethanes system which incorporates polyhedral oligomeric silsesquioxane into conventional biodegradable thermoplastic polyurethanes built up by poly(?-caproactone) and polyethylene glycol blocks, resulting in biostability. The multi-block thermoplastic polyurethanes are synthesized from lysine-diisocyanate with poly(?-caprolactone)-diol, polyhedral oligomeric silsesquioxane-diol, and poly(ethylene glycol) using a one-step synthesis process.
    Type: Application
    Filed: April 22, 2011
    Publication date: October 27, 2011
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Patrick Mather, Jian Wu, Xinzhu Gu