Patents by Inventor Xinzhu Gu
Xinzhu Gu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11529318Abstract: Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided.Type: GrantFiled: June 18, 2018Date of Patent: December 20, 2022Assignees: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, DEPARTMENT OF VETERANS AFFAIRSInventors: Kia M. Washington, William R. Wagner, Michael Brandt Steketee, Yolandi Van der Merwe, Xinzhu Gu
-
Publication number: 20220160526Abstract: The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices include a combination or integration of superelastic material, biodegradable metal and, thin film nitinol and/or biodegradable polymer. A structural frame is formed of individual elongated pieces composed of biodegradable metal. These pieces are joined together by connector pieces composed of superelastic material. At least a portion of the structural frame has deposited thereon the thin film nitinol and/or biodegradable polymer. The structural frame of the device is collapsible for insertion in a delivery tube and, recoverable for deployment and placement in a vascular location of a patient body.Type: ApplicationFiled: December 2, 2020Publication date: May 26, 2022Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: YOUNGJAE CHUN, WILLIAM R. WAGNER, XINZHU GU, PETER DREW WEARDEN, TOMO YOSHIZUMI
-
Patent number: 10888442Abstract: The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices include a combination or integration of superelastic material, biodegradable metal and, thin film nitinol and/or biodegradable polymer. A structural frame is formed of individual elongated pieces composed of biodegradable metal. These pieces are joined together by connector pieces composed of superelastic material. At least a portion of the structural frame has deposited thereon the thin film nitinol and/or biodegradable polymer. The structural frame of the device is collapsible for insertion in a delivery tube and, recoverable for deployment and placement in a vascular location of a patient body.Type: GrantFiled: November 11, 2015Date of Patent: January 12, 2021Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Youngjae Chun, William R. Wagner, Xinzhu Gu, Peter Drew Wearden, Tomo Yoshizumi
-
Patent number: 10744308Abstract: The invention relates to an in-utero ventriculoamniotic shunting device that includes a shunt tube (26) composed of polymer composite and having metallic wire embedded therein, one or more anchors (30) composed of superelastic wire, e.g., thermal shape-set nitinol structures, that are mechanically attached to an exterior surface of the shunt tube (26), and a one-way passive valve (32) composed of a thin polymer membrane. The anchors (30) are effective to prevent migration and dislodgement of the shunting device following its deployment, and the valve (32) is effective to prevent the backflow of amniotic fluid (23).Type: GrantFiled: October 13, 2016Date of Patent: August 18, 2020Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Yanfei Chen, Young Jae Chun, Stephen Emery, Xinzhu Gu, William Wagner, Stephanie Greene
-
Patent number: 10336911Abstract: A waterborne shape memory polymer coating that gives textiles and fibers good shape memory performance. An amphiphilic, crosslinkable grafted polysaccharide polymer was synthesized and provided in a water dispersion that can be applied to a flexible fibrous material and then crosslinked to yield good shape memory properties. The polymer coating showed good binding to human hair, which could be styled into a permanent shape (e.g., straight) during the crosslinked step. Next, this permanent shape can be styled to a temporary shape (e.g. curly) by heating and styling, and cooling. Finally, the permanent style can be regained by activation with water, heat, or both.Type: GrantFiled: March 14, 2014Date of Patent: July 2, 2019Assignee: Syracuse UniversityInventors: Patrick T. Mather, Xinzhu Gu
-
Publication number: 20180369160Abstract: Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided.Type: ApplicationFiled: June 18, 2018Publication date: December 27, 2018Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, DEPARTMENT OF VETERANS AFFAIRSInventors: Kia M. Washington, William R. Wagner, Michael Brandt Steketee, Yolandi Van der Merwe, Xinzhu Gu
-
Publication number: 20180296810Abstract: The invention relates to an in-utero ventriculoamniotic shunting device that includes a shunt tube (26) composed of polymer composite and having metallic wire embedded therein, one or more anchors (30) composed of superelastic wire, e.g., thermal shape-set nitinol structures, that are mechanically attached to an exterior surface of the shunt tube (26), and a one-way passive valve (32) composed of a thin polymer membrane. The anchors (30) are effective to prevent migration and dislodgement of the shunting device following its deployment, and the valve (32) is effective to prevent the backflow of amniotic fluid (23).Type: ApplicationFiled: October 13, 2016Publication date: October 18, 2018Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Yanfei Chen, Young Jae Chun, Stephen Emery, Xinzhu Gu, William Wagner, Stephanie Greene
-
Publication number: 20170340463Abstract: The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices include a combination or integration of superelastic material, biodegradable metal and, thin film nitinol and/or biodegradable polymer. A structural frame is formed of individual elongated pieces composed of biodegradable metal. These pieces are joined together by connector pieces composed of superelastic material. At least a portion of the structural frame has deposited thereon the thin film nitinol and/or biodegradable polymer. The structural frame of the device is collapsible for insertion in a delivery tube and, recoverable for deployment and placement in a vascular location of a patient body.Type: ApplicationFiled: November 11, 2015Publication date: November 30, 2017Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: YOUNGJAE CHUN, WILLIAM R. WAGNER, XINZHU GU, PETER DREW WEARDEN, TOMO YOSHIZUMI
-
Publication number: 20160032140Abstract: A waterborne shape memory polymer coating that gives textiles and fibers good shape memory performance. An amphiphilic, crosslinkable grafted polysaccharide polymer was synthesized and provided in a water dispersion that can be applied to a flexible fibrous material and then crosslinked to yield good shape memory properties. The polymer coating showed good binding to human hair, which could be styled into a permanent shape (e.g., straight) during the crosslinked step. Next, this permanent shape can be styled to a temporary shape (e.g. curly) by heating and styling, and cooling. Finally, the permanent style can be regained by activation with water, heat, or both.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: Syracuse UniversityInventors: Patrick T. MATHER, Xinzhu GU
-
Patent number: 9249254Abstract: A multi-block thermoplastic polyurethanes system which incorporates polyhedral oligomeric silsesquioxane into conventional biodegradable thermoplastic polyurethanes built up by poly(?-caproactone) and polyethylene glycol blocks, resulting in biostability. The multi-block thermoplastic polyurethanes are synthesized from lysine-diisocyanate with poly(?-caprolactone)-diol, polyhedral oligomeric silsesquioxane-diol, and poly(ethylene glycol) using a one-step synthesis process.Type: GrantFiled: April 22, 2011Date of Patent: February 2, 2016Assignee: Syracuse UniversityInventors: Patrick Mather, Jian Wu, Xinzhu Gu
-
Publication number: 20110263808Abstract: A multi-block thermoplastic polyurethanes system which incorporates polyhedral oligomeric silsesquioxane into conventional biodegradable thermoplastic polyurethanes built up by poly(?-caproactone) and polyethylene glycol blocks, resulting in biostability. The multi-block thermoplastic polyurethanes are synthesized from lysine-diisocyanate with poly(?-caprolactone)-diol, polyhedral oligomeric silsesquioxane-diol, and poly(ethylene glycol) using a one-step synthesis process.Type: ApplicationFiled: April 22, 2011Publication date: October 27, 2011Applicant: SYRACUSE UNIVERSITYInventors: Patrick Mather, Jian Wu, Xinzhu Gu