Patents by Inventor Xinzhu ZHANG

Xinzhu ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused tricyclic heterocycle compounds and therapeutic uses thereof
    Patent number: 11535633
    Abstract: This application discloses a new class of fused tricyclic heterocycles of formula (I), preparation methods thereof, pharmaceutical compositions comprising these compounds, and pharmaceutically acceptable salts, solvates, or prodrugs thereof, and their uses for the treatment of diseases in which modulation of STING is beneficial, for example, cancers, pre-cancerous disorders, and viral infections.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: December 27, 2022
    Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Dong Liu, Lei Chen, Linghang Zhuang, Puhui Li, Xinzhu Zhang, Chunying Song, Matthew Miller, Qiyue Hu, Yuna Yan, Feng He, Weikang Tao
  • TRICYCLIC COMPOUNDS AS STING AGONISTS, AND PREPARATION METHODS AND MEDICINAL USES THEREOF
    Publication number: 20220056044
    Abstract: Compounds of formula (I) useful as agonists of stimulator of interferon genes (STING), the preparation method therefor, pharmaceutical compositions comprising the compounds, and the pharmaceutical uses for the treatment of STING-mediated diseases or disorders are disclosed.
    Type: Application
    Filed: December 14, 2019
    Publication date: February 24, 2022
    Inventors: Dong Liu, Puhui Li, Linghang Zhuang, Fengqi Zhang, Lei Chen, Xinzhu Zhang, Chunying Song, Suxing Liu, Matthew Miller, Qiyue Hu, Yuna Yan, Jing Li, Feng He, Weikang Tao
  • ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF
    Publication number: 20220009909
    Abstract: Compounds of formula (I) useful as inhibitors of ADAMTS-5 and/or ADAMTS-4, pharmaceutical compositions thereof, and use of them as therapeutic agents for the treatment of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthritis and/or rheumatoid arthritis, are disclosed.
    Type: Application
    Filed: June 30, 2021
    Publication date: January 13, 2022
    Inventors: Dong Liu, Peng Zhao, Jian Liu, Linghang Zhuang, Xinzhu Zhang, Chunying Song, Suxing Liu
  • FUSED TRICYCLIC HETEROCYCLE COMPOUNDS AND THERAPEUTIC USES THEREOF
    Publication number: 20210300944
    Abstract: This application discloses a new class of fused tricyclic heterocycles of formula (I), preparation methods thereof, pharmaceutical compositions comprising these compounds, and pharmaceutically acceptable salts, solvates, or prodrugs thereof, and their uses for the treatment of diseases in which modulation of STING is beneficial, for example, cancers, pre-cancerous disorders, and viral infections.
    Type: Application
    Filed: June 28, 2019
    Publication date: September 30, 2021
    Inventors: Dong Liu, Lei Chen, Linghang Zhuang, Puhui Li, Xinzhu Zhang, Chunying Song, Matthew Miller, Qiyue Hu, Yuna Yan, Feng He, Weikang Tao
  • Method and device for detecting damage rate of an inner coating of a downhole oil casing
    Patent number: 10641723
    Abstract: This disclosure provides a method and device for detecting the damage rate of an inner coating of a downhole oil casing. The method includes filling the oil casing with electrolyte, obtaining the well depth-detection current on a discharge electrode in a process of moving the discharge electrode from one end of the oil casing to the other end of the oil casing, and determining a well depth-damage rate state of the inner coating of the oil casing according to the well depth-detection current. This application can realize quantitative judgment for the damage rate of an inner coating of a downhole oil casing, resulting in rapid in detection speed, convenient and safe in operation, and low detection cost.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: May 5, 2020
    Assignee: PetroChina Company Limited
    Inventors: Qiongwei Li, Bihai Cheng, Zewei Tang, Jianqiang Xue, Caili Fu, Huili Yang, Zhiwu He, Lihua Yang, Xinzhu Zhang, Yulai Sun
  • METHOD AND DEVICE FOR DETECTING DAMAGE RATE OF AN INNER COATING OF A DOWNHOLE OIL CASING
    Publication number: 20180209928
    Abstract: This disclosure provides a method and device for detecting the damage rate of an inner coating of a downhole oil casing. The method includes filling the oil casing with electrolyte, obtaining the well depth-detection current on a discharge electrode in a process of moving the discharge electrode from one end of the oil casing to the other end of the oil casing, and determining a well depth-damage rate state of the inner coating of the oil casing according to the well depth-detection current. This application can realize quantitative judgment for the damage rate of an inner coating of a downhole oil casing, resulting in rapid in detection speed, convenient and safe in operation, and low detection cost.
    Type: Application
    Filed: March 21, 2018
    Publication date: July 26, 2018
    Applicant: PETROCHINA COMPANY LIMITED
    Inventors: Qiongwei LI, Bihai CHENG, Zewei TANG, Jianqiang XUE, Caili FU, Huili YANG, Zhiwu HE, Lihua YANG, Xinzhu ZHANG, Yulai SUN