Abstract: A method for detection and pathological classification of polyps via colonoscopy based on an anchor-free technique includes: performing feature extraction on a color endoscopic image that is pretreated, enhancing and extending the extracted features, decoding the feature information of the enhanced feature and the extended feature through an anchor-free detection algorithm to acquire a polyp prediction box and a prospect prediction mask, then respectively extracting global and local feature vectors from the extended feature and the prospect prediction mask, and combining the global feature vector with the local feature vector, so as to predict the type of polyps through a full-connection layer. Through the present application, the type of polyps can be correctly predicted, and the detection rate of polyps and the accuracy rate of pathological classification are improved.

Abstract: Disclosed is an anticancer composition containing auranofin and a mercapto compound and the use thereof. The composition contains auranofin and the mercapto compound. By the combined use of auranofin and the mercapto compound, the problem that auranofin cannot effectively inhibit the proliferation of cancer cells under normal physiological condition is solved. When combined with the mercapto compound, auranofin can inhibit tumor growth well, indicating that the combination of auranofin and the mercapto compound can be used as an anticancer drug composition. Moreover, the uptake of auranofin in tumor tissues also can be adjusted by regulating the type of mercapto compound, and thus, providing better selectivity in vivo anti-cancer.

Abstract: The present invention discloses a method of treating tumor using a novel pyrimidine derivative. It is demonstrated through the tests on anti-tumor activity at the cellular level (tumor cells expressed with c-Met) that, through the introduction of a chiral structure in the molecule, the introduction of an isotope of hydrogen (deuterium) at the sites that are prone to metabolism in the molecule, and the introduction of atoms or groups such as sulfur, selenium and sulfoxide in the molecule, the compounds of the invention have excellent anti-tumor activities, and the stabilities of the anti-tumor compounds are significantly improved.

Abstract: The present invention discloses a novel pyrimidine derivative and a preparation process thereof and a use thereof in anti-tumor drugs. It is demonstrated through the tests on anti-tumor activity at the cellular level (tumor cells expressed with c-Met) that, through the introduction of a chiral structure in the molecule, the introduction of an isotope of hydrogen (deuterium) at the sites that are prone to metabolism in the molecule, and the introduction of atoms or groups such as sulfur, selenium and sulfoxide in the molecule, the compounds of the invention have excellent anti-tumor activities, and the stabilities of the anti-tumor compounds are significantly improved.

Abstract: The present invention discloses a pyrimidine derivative containing one deuterium atom, a preparation process thereof and a use thereof. It is demonstrated through in vivo and in vitro animal experiments that the antitumor activity of the pyrimidine derivative containing one deuterium atom provided in the disclosure is significantly superior to that of the positive drug Tepotinib, and the preparation process is simple and low in cost.