Abstract: Provided are compounds of Formula (I) or (II) and related compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: Systems and methods are described for making repair decisions to improve resilience of a utility distribution network (UDN). A graph convolutional network (GCN) integrates reinforcement learning to provide an integrated model framework, in which the GCN encodes the information of the UDN, such as topology and operating characteristics. A neural network is connected to the GCN, and the framework trains the neural network to provide a recovery sequence based on the current state (e.g., a damaged state) of the UDN based one or more performance indicators.

Abstract: Provided are compounds of Formula I, compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: In a described example, a system for leak detection and localization is provided. The system includes a water distribution network (WDN) partition stage programmed to cluster a WDN model into partition zones based on applying a modified k-means clustering algorithm to leakage characteristic data and physical connectivity data. A leakage monitoring stage can be programmed to detect the occurrence of leakage in the WDN and provide leak detection data based on applying a trained unsupervised leakage detection machine-learning model to the partition zones and sensor data. The leakage monitoring stage can also provide localization data to identify a location of a leakage zone in the WDN based on feeding the leak detection data to a localization machine-learning model.

Abstract: A curing agent for disposal of municipal solid waste incineration (MSWI) fly ash and a preparation method and use method thereof are provided. In the present disclosure, a loofah nanofiber crystal, a rice husk ash (RHA), sodium hydroxide, and water are adopted as raw materials to prepare the curing agent, and the curing agent can effectively realize the safe disposal and curing of heavy metals in an MSWI fly ash. The highest curing rates of the curing agent for heavy metals Pb2+, Zn2+, Cd2+, Cr3+, and Cu2+ can reach 99.7%, 99.4%, 99.5%, 98.7%, and 99.5%, respectively. The special three-dimensional (3D) cross-linked network structure of the loofah nanofiber crystal and the excellent physical and chemical adsorption properties and ion exchange capacity of the RHA are fully used in the curing agent of the present disclosure.

Abstract: The present teaching relates to adjustable one-time password (OTP) setup, sign-in, and verification. In one example, a first length of a signature is determined. The signature has been used previously by a first user to initially sign in a second device. A second length that is different from the first length is determined. A signing key is generated based at least partially on the second length. A new signature having the second length is generated based on the signing key. The new signature is provided to a second user so that the second user can input at least a portion of the new signature into the second device for a subsequent sign in. The verification key is generated based at least partially on the new signature. The new signature input by the second user into the second device is transmitted from the second device to the third device.

Abstract: The present teaching relates to adjustable one-time password (OTP) setup, sign-in, and verification. In one example, a first length of a signature is determined. The signature has been used previously by a first user to initially sign in a second device. A second length that is different from the first length is determined. A signing key is generated based at least partially on the second length. A new signature having the second length is generated based on the signing key. The new signature is provided to a second user so that the second user can input at least a portion of the new signature into the second device for a subsequent sign in. The verification key is generated based at least partially on the new signature. The new signature input by the second user into the second device is transmitted from the second device to the third device.