Patents by Inventor Xiongbin XU

Xiongbin XU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZOXAZINONE DERIVATIVES
    Publication number: 20250034099
    Abstract: A class of benzoxazinone derivatives and a preparation method therefor, specifically related to a compound shown in formula (II), or a stereoisomer or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 14, 2022
    Publication date: January 30, 2025
    Applicants: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., MEDSHINE DISCOVERY INC.
    Inventors: Lingyun WU, Zheming XIAO, Yi CHEN, Xiongbin XU, Wei XIA, Tangyang GUO, Lan CAO, Chi-chung CHAN, Qiu LI, Jian LI, Shuhui CHEN
  • 5-SUBSTITUTED PYRIDINE-2(1H)-KETONE COMPOUND AND USE THEREOF
    Publication number: 20240383906
    Abstract: The present invention relates to a class of 5-substituted pyridine-2 (1H)-ketone compounds and a use thereof, and specifically relates to a compound as shown in formula (X) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 28, 2022
    Publication date: November 21, 2024
    Inventors: Xiongbin XU, Yi CHEN, Guang DONG, Lingyun WU, Shuhui CHEN
  • SALT FORM OF PYRROLOTRIAZINE COMPOUND, CRYSTAL FORM THEREOF, AND PREPARATION METHOD THEREFOR
    Publication number: 20240254144
    Abstract: A pyrrolotriazine compound, e.g., the compound of formula (II), a salt form thereof, a crystal form thereof, a preparation method therefor, and an application thereof are provided. An application in preparation of MNK1/2 inhibitor drugs and/or in preparation of drugs for treating colorectal cancer are also provided.
    Type: Application
    Filed: May 7, 2022
    Publication date: August 1, 2024
    Inventors: Lingyun WU, Xiawei WEI, Xu YOU, Xiongbin XU, Ning JIANG, Shuhui CHEN
  • Uracil compound as c-MET/AXL inhibitor
    Patent number: 11623923
    Abstract: Provided are a uracil compound represented by Formula (IV) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition of the same. Also provided is a use thereof as a c-MET/AXL inhibitor in preparing a c-MET/AXL-inhibiting drug or a drug for treating a tumor.
    Type: Grant
    Filed: November 23, 2018
    Date of Patent: April 11, 2023
    Assignee: MEDSHINE DISCOVERY, INC.
    Inventors: Jinping Li, Xiongbin Xu, Gang Li, Lihong Hu, Charles Z. Ding, Yaling Zhou, Guoping Hu, Jian Li, Shuhui Chen
  • COMPOUND AS SMALL MOLECULE INHIBITOR PD-1/PD-L1 AND APPLICATION THEREOF
    Publication number: 20220402917
    Abstract: A biaryl compound. Specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 30, 2020
    Publication date: December 22, 2022
    Inventors: Lingyun WU, Cailin WANG, Xiongbin XU, Haijun TONG, Shuhui CHEN
  • Crystal form of c-MET inhibitor and salt form thereof and preparation method therefor
    Patent number: 11465986
    Abstract: Disclosed are a crystal form of a c-MET inhibitor and a salt form thereof and a preparation method therefor. Specifically involved are the compound as shown in formula (I), and a salt form and a crystal form thereof, and also included is the use of the crystal form and the salt form in the preparation of medicines for treating cancers.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: October 11, 2022
    Assignee: FUJIAN AKEYLINK BIOTECHNOLOGY CO., LTD.
    Inventors: Xiongbin Xu, Gang Li, Ting Yao, Kun Wang, Lihong Hu, Charles Z. Ding
  • Borate of azetidine derivative
    Patent number: 11466036
    Abstract: A borate compound of an azetidine derivative, relating in particular to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof or a geometric isomer thereof, as well as a use thereof in the preparation of a drug used for the treatment or prevention of multiple myeloma.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: October 11, 2022
    Assignee: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    Inventors: Jian Xiong, Cheng Xie, Xiongbin Xu, Kevin X Chen, Jian Li, Shuhui Chen, Aiming Zhang, Xiquan Zhang, Xin Tian
  • COMPOUND AS PORCUPINE INHIBITOR AND USE THEREOF
    Publication number: 20220281873
    Abstract: Disclosed is a class of porcupine inhibitors, specifically a compound as represented by formula (I), and a pharmaceutically acceptable salt or an isomer thereof.
    Type: Application
    Filed: July 8, 2020
    Publication date: September 8, 2022
    Applicant: MEDSHINE DISCOVERY INC.
    Inventors: Xiongbin XU, Yi CHEN, Cailin WANG, Ru FENG, Wen JIANG, Lingyun WU, Jian LI, Shuhui CHEN
  • URACIL COMPOUND AS C-MET/AXL INHIBITOR
    Publication number: 20210371395
    Abstract: Provided are a uracil compound represented by Formula (IV) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition of the same. Also provided is a use thereof as a c-MET/AXL inhibitor in preparing a c-MET/AXL-inhibiting drug or a drug for treating a tumor.
    Type: Application
    Filed: November 23, 2018
    Publication date: December 2, 2021
    Applicant: MEDSHINE DISCOVERY, INC.
    Inventors: Jinping LI, Xiongbin XU, Gang LI, Lihong HU, Charles Z. DING, Yaling ZHOU, Guoping HU, Jian LI, Shuhui CHEN
  • CRYSTAL FORM OF C-MET INHIBITOR AND SALT FORM THEREOF AND PREPARATION METHOD THEREFOR
    Publication number: 20210238163
    Abstract: Disclosed are a crystal form of a c-MET inhibitor and a salt form thereof and a preparation method therefor. Specifically involved are the compound as shown in formula (I), and a salt form and a crystal form thereof, and also included is the use of the crystal form and the salt form in the preparation of medicines for treating cancers.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 5, 2021
    Applicant: FUJIAN COSUNTER PHARMACEUTICAL CO., LTD.
    Inventors: Xiongbin XU, Gang LI, Ting YAO, Kun WANG, Lihong HU, Charles Z. DING
  • BORATE OF AZETIDINE DERIVATIVE
    Publication number: 20210163507
    Abstract: A borate compound of an azetidine derivative, relating in particular to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof or a geometric isomer thereof, as well as a use thereof in the preparation of a drug used for the treatment or prevention of multiple myeloma.
    Type: Application
    Filed: August 2, 2019
    Publication date: June 3, 2021
    Inventors: Jian Xiong, Cheng Xie, Xiongbin Xu, Kevin X Chen, Jian Li, Shuhui Chen, Aiming Zhang, Xiquan Zhang, Xin Tian
  • Azetidine derivative
    Patent number: 11014943
    Abstract: Disclosed in the present application are a compound represented by formula (I), or a pharmaceutically acceptable salt, a tautomer thereof, a stereoisomer thereof, or a geometrical isomer thereof, and uses thereof in the preparation of drugs for treating or preventing multiple myeloma.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: May 25, 2021
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP GO., LTD.
    Inventors: Jian Xiong, Cheng Xie, Kevin X Chen, Xiongbin Xu, Xuejin Zhang, Zhen Gong, Jian Li, Shuhui Chen, Aiming Zhang, Zhulian Jiang, Xiquan Zhang, Xin Tian
  • AZETIDINE DERIVATIVE
    Publication number: 20200115392
    Abstract: Disclosed in the present application are a compound represented by formula (I), or a pharmaceutically acceptable salt, a tautomer thereof, a stereoisomer thereof, or a geometrical isomer thereof, and uses thereof in the preparation of drugs for treating or preventing multiple myeloma.
    Type: Application
    Filed: February 28, 2018
    Publication date: April 16, 2020
    Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Jian XIONG, Cheng XIE, Kevin X CHEN, Xiongbin XU, Xuejin ZHANG, Zhen GONG, Jian LI, Shuhui CHEN, Aiming ZHANG, Zhulian JIANG, Xiquan ZHANG, Xin TIAN
  • Pyridone compound as c-met inhibitor
    Patent number: 10501443
    Abstract: Disclosed in the present invention is a type of pyridone compounds as c-met inhibitors, and specifically disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: December 10, 2019
    Assignee: FUJIAN COSUNTER PHARMACEUTICAL CO., LTD.
    Inventors: Xiongbin Xu, Gang Li, Charles Z. Ding, Lihong Hu, Guoping Hu, Jian Li, Shuhui Chen, Zhigang Chi, Kun Wang
  • PYRIDONE COMPOUND AS C-MET INHIBITOR
    Publication number: 20190248763
    Abstract: Disclosed in the present invention is a type of pyridone compounds as c-met inhibitors, and specifically disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 23, 2017
    Publication date: August 15, 2019
    Applicant: FUJIAN COSUNTER PHARMACEUTICAL CO., LTD.
    Inventors: Xiongbin XU, Gang LI, Charles Z. DING, Lihong HU, Guoping HU, Jian LI, Shuhui CHEN, Zhigang CHI, Kun WANG
  • Linkers and their application towards ADC
    Patent number: 10280229
    Abstract: The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: May 7, 2019
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Chun Sing Li, Jian Li, Yong Cang, Shuhui Chen, Gang Li, Xiongbin Xu, Lun Lu
  • LINKERS AND THEIR APPLICATION TOWARDS ADC
    Publication number: 20170202974
    Abstract: The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.
    Type: Application
    Filed: July 13, 2015
    Publication date: July 20, 2017
    Applicant: MEDSHINE DISCOVERY INC.
    Inventors: Chun Sing LI, Jian LI, Yong CANG, Shuhui CHEN, Gang LI, Xiongbin XU, Lun LU
  • Welder shell
    Patent number: D1004652
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: November 14, 2023
    Inventor: Xiongbin Xu