Abstract: Disclosed are compounds of Formula A, or a salt thereof: Wherein “A1”, R1, R2, R3, R6, and R7 are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch and neuropathic pain disorders using the same.

Abstract: A method and a device for nidus recognition in a neuroimage, an electronic apparatus, and a storage medium are provided. A collection of neuroimages to be recognized, including a first structural image, a first nidus image, and a first metabolic image, is determined, and then image preprocessing is performed on the collection of neuroimages to acquire a collection of object images including a second structural image, a second nidus image, and a second metabolic image. The collection of object images is input into a trained three-dimensional convolutional neural network to acquire a position of a nidus of the target object, and then the position of the nidus is labeled on the first structural image based on the position of the nidus of the target object to acquire and display an image of the position of the nidus.

Abstract: The invention provides an automatic stirring device in the field of fluid machinery and bioreactors, focusing on enhancing fluid control efficiency and consistency in biological cultivation processes. It utilizes a flexible channel body or reactor body to facilitate the flow of nutrient solution along specific channels (such as S-shaped flexible channels or S-shaped loop channels), designed to reduce shear forces and achieve iso-level uniform flow. A power system and monitoring and control system are employed to regulate the flow of nutrient solution and monitor cultivation conditions in real-time, thus supporting various bioprocess cultivation requirements.

Abstract: Disclosed are compounds of Formula A, or a salt thereof: Wherein “A1”, R1, R2, R3, R6, and R7 are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch and neuropathic pain disorders using the same.

Abstract: In a device for producing quantitative-diameter spray droplets of pesticide, a driving motor is controlled by a control center, the driving motor drives a lead screw, the lead screw drives a sliding device to achieve a designated accurate position on a guide track, and a piston moves slowly along with the sliding device to extrude chemicals in a droplet generator quantitatively, the chemicals extruded by the piston through the motion in a droplet cavity forms small single droplets through a guide pipe, the droplets with specific particle size are further generated by precisely controlling the extrusion amount of the chemicals, so that the device can be widely used for studies about diffusion of the droplets evaporation property of the single droplets and the like tested by water-sensitive paper, as well as tests of the properties of the pesticide, and further has broad application prospects.

Abstract: Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.

Abstract: Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.

Abstract: In a device for producing quantitative-diameter spray droplets of pesticide, a driving motor is controlled by a control center, the driving motor drives a lead screw, the lead screw drives a sliding device to achieve a designated accurate position on a guide track, and a piston moves slowly along with the sliding device to extrude chemicals in a droplet generator quantitatively, the chemicals extruded by the piston through the motion in a droplet cavity forms small single droplets through a guide pipe, the droplets with specific particle size are further generated by precisely controlling the extrusion amount of the chemicals, so that the device can be widely used for studies about diffusion of the droplets evaporation property of the single droplets and the like tested by water-sensitive paper, as well as tests of the properties of the pesticide, and further has broad application prospects.

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Y and Z are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.

Abstract: Compounds of formula (II): known as: 5-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-yloxy]pyridazin-3-yl}-1-H-indole salt with (2R, 3R)-2,3-dihydroxybutanedioic acid (1:1).

Abstract: A compound of the formula is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed.

Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.

Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.

Abstract: In an interactive display system, a transmitter is provided for transmitting a periodic signal to a plurality of receivers through the air. One or more phase differences are measured between the receiving at pairs of receivers. These phase differences control the coordinates of a locator on a display screen. Separate measured phase differences control the positions along different coordinate axes independently.