Patents by Inventor XIUFANG GUO

XIUFANG GUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formation of neuromuscular junctions in a co-culture comprising rat muscle cells overlayered with differentiated human spinal cord stem cells in a serum free medium
    Patent number: 9952204
    Abstract: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more rat muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a rat muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: April 24, 2018
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Xiufang Guo, Mercedes Gonzalez, Maria Stancescu
  • NOCICEPTOR-LIKE CELLS DIFFERENTIATED FROM HUMAN NEURAL PROGENITORS AND USES THEREOF
    Publication number: 20170045499
    Abstract: Disclosed herein are methods of differentiating human neural progenitor cells to nociceptor-like cells. Also disclosed are methods of making an innervated skin-like construct using nociceptor-like cells differentiated from human neural progenitor cells. Also disclosed are engineered constructs for screening potentially therapeutic compounds that include a skin-like construct and nociceptor-like cells differentiated from human neural progenitor cells. Also disclosed is a method of screening potential therapies.
    Type: Application
    Filed: August 12, 2016
    Publication date: February 16, 2017
    Inventors: James J. Hickman, Xiufang Guo
  • Synthetic mammalian neuromuscular junction and method of screening for a candidate drug thereon
    Patent number: 9267936
    Abstract: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: February 23, 2016
    Assignee: University of Central Florida Research Foundation
    Inventors: James Hickman, Xiufang Guo
  • COMPOSITIONS AND METHODS FOR GENERATING NEURAL CREST STEM CELLS AND SENSORY NEURONS
    Publication number: 20150299652
    Abstract: In an aspect, the invention relates to compositions, methods, and kits for generating neural crest stem cells, sensory neurons, and Schwann cells. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: November 27, 2013
    Publication date: October 22, 2015
    Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC.
    Inventors: Xiufang GUO, Severo SPRADLING, James J. HICKMAN
  • Synthetic Mammalian Neuromuscular Junction and Method of Making
    Publication number: 20140349884
    Abstract: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.
    Type: Application
    Filed: August 6, 2014
    Publication date: November 27, 2014
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Xiufang Guo
  • Synthetic mammalian neuromuscular junction and method of making
    Patent number: 8835168
    Abstract: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: September 16, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Xiufang Guo
  • FORMATION OF NEUROMUSCULAR JUNCTIONS IN A DEFINED SYSTEM
    Publication number: 20130115694
    Abstract: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.
    Type: Application
    Filed: May 6, 2011
    Publication date: May 9, 2013
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Xiufang Guo
  • FORMATION OF NEUROMUSCULAR JUNCTIONS IN A DEFINED SYSTEM
    Publication number: 20110250682
    Abstract: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more rat muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a rat muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.
    Type: Application
    Filed: May 6, 2011
    Publication date: October 13, 2011
    Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: JAMES HICKMAN, XIUFANG GUO, MERCEDES GONZALEZ, MARIA STANCESCU