Patents by Inventor Xiufen Zhou

Xiufen Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYMATIC PHOSPHOROTHIOATION OF DNA OR RNA
    Publication number: 20140308711
    Abstract: This invention relates to methods, compositions, and kits for enzymatic phosphorothioation of the sugar-phosphate backbone of nucleic acids. The invention allows for phosphorothioation of pre-existing nucleic acids.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 16, 2014
    Applicants: Massachusetts Institute of Technology, Wuhan University, Shanghai Jiaotong University
    Inventors: Peter C. Dedon, Delin You, Bo Cao, Ramesh Babu Indrakanti, Michael S. DeMott, Lianrong Wang, Zixin Deng, Xiufen Zhou
  • Genes for synthesis of FR-008 polyketides
    Patent number: 7595156
    Abstract: The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: September 29, 2009
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Sang Yup Lee, Zixin Deng, Shi Chen, Ki Jun Jeong, Xiufen Zhou
  • Genes for synthesis of FR-008 polyketides
    Publication number: 20050089884
    Abstract: The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.
    Type: Application
    Filed: April 6, 2004
    Publication date: April 28, 2005
    Inventors: Sang Lee, Zixin Deng, Shi Chen, Ki Jeong, Xiufen Zhou