Abstract: The present invention relates to an isoindol-sulfilimine compound and its preparation and its use as a sigma-2 receptor inhibitor. Compared with the prior art, the isoindol-sulfilimine compound prepared by the present invention can effectively inhibit the sigma-2 receptor activity by binding to the sigma-2 receptor and deformationally regulating the sigma-2 receptor complex, which will lead to the instability of the binding of adjacent A? oligomers to the receptor on the synapse, thus leading to the removal of AB oligomers from the synapse. It can be further used for the preparation of new therapeutic drugs for tumor and neurodegenerative diseases.

Abstract: The present invention relates to an isoindol-sulfilimine compound and its preparation and its use as a sigma-2 receptor inhibitor. Compared with the prior art, the isoindol-sulfilimine compound prepared by the present invention can effectively inhibit the sigma-2 receptor activity by binding to the sigma-2 receptor and deformationally regulating the sigma-2 receptor complex, which will lead to the instability of the binding of adjacent A? oligomers to the receptor on the synapse, thus leading to the removal of A? oligomers from the synapse. It can be further used for the preparation of new therapeutic drugs for tumor and neurodegenerative diseases.

Abstract: A system for reducing or eliminating PIM interference in an RX signal is disclosed. The system is configured to use RX and TX signals to generate a frequency-shifted output that includes a RX carrier signal component of the RX signal, as well as first and second TX carrier signal components of the TX signal, positioned in a frequency spectrum so that a frequency spacing between the first and the second TX carrier signal components and a frequency spacing between the RX carrier signal component and a closest one of the first and the TX second carrier signal components is smaller than a frequency spacing between the first and the second TX carrier signal components in the TX signal. The system may then use the frequency-shifted output to generate an estimate of a PIM signal component in the RX signal.

Abstract: A method for measuring active power of alternating current (AC) using a digital phase-locked loop (DPLL) includes the steps of (1) generating via the DPLL a pair of substantially mutually orthogonal sinusoid signals in response to an input voltage data signal, (2) mixing a first sinusoid signal of the pair with a current data signal of the alternating current via a first low-pass filter, (3) mixing the first sinusoid signal of the pair with a voltage signal of the alternating current via a second low-pass filter, and (4) computing an active power of the alternating current based on an output from the first low-pass filter and an output from the second low-pass filter.

Abstract: A method and device for measuring active power of AC with respect to a fundamental frequency or harmonic frequencies using a DPLL include generating via the DPLL a pair of substantially mutually orthogonal sinusoid signals in response to an input voltage data signal, mixing a first sinusoid signal of the pair with a current data signal of the alternating current via a first low-pass filter, mixing the first sinusoid signal of the pair with a voltage signal of the alternating current via a second low-pass filter, and computing an active power of the alternating current based on a further mixing of an output from the first low-pass filter and an output from the second low-pass filter.