Abstract: Disclosed herein is a novel chimeric antigen receptor and use thereof. The novel chimeric antigen receptor consists of a signal peptide, an antigen binding domain, a transmembrane region, and an intracellular signal domain, and comprises a 4-1BB signal peptide and/or a 4-1BB molecular transmembrane region. Nucleic acid sequences of various chimeric antigen receptors are separated and purified and provided is a chimeric antigen receptor and a CAR-T cell which are specific for a CD19 malignant tumor antigen. In the malignant tumor killing test of hematological cell lines, the ability of immune cells to target and recognize tumor cells is significantly enhanced, and the killing activity against tumor cells is also enhanced.

Abstract: Disclosed herein is a novel chimeric antigen receptor and use thereof. The novel chimeric antigen receptor consists of a signal peptide, an antigen binding domain, a transmembrane region, and an intracellular signal domain, and comprises a 4-1BB signal peptide and/or a 4-1BB molecular transmembrane region. Nucleic acid sequences of various chimeric antigen receptors are separated and purified and provided is a chimeric antigen receptor and a CAR-T cell which are specific for a CD19 malignant tumor antigen. In the malignant tumor killing test of hematological cell lines, the ability of immune cells to target and recognize tumor cells is significantly enhanced, and the killing activity against tumor cells is also enhanced.

Abstract: A uniplanar pedicle screw comprises a screw base, a positioning compression ring and a ball-head screw. Lateral bosses are provided at left and right sides of an upper portion of a ball head of the ball-head screw, and upper side surfaces of the lateral bosses are arc-shaped and project upwards. A central boss is provided on the ball head of the ball-head screw between the two lateral bosses, and an upper side surface of the central boss is arc-shaped and protrudes upwards. An arc center of the central boss and a connecting line of arc centers of the two lateral bosses are on the same straight line. Arc-shaped concave surfaces matching the two lateral bosses are provided at a lower portion of the positioning compression ring and at left and right sides of a rod accommodating groove.

Abstract: A grasping end of a frog-style forceps relates to the technical field of medical instrument for spinal surgery, and comprises a grasping end tube and a pressing-rod sleeve. The pressing-rod sleeve is sleeved over the grasping end tube. Two opposite strip-shaped openings are axially provided on a side wall of the grasping end tube. Positioning spring sheets are disposed inside the strip-shaped openings. Positioning protrusions are disposed on inner sides of lower end portions of the two positioning spring sheets inside the strip-shaped openings at a lower portion of the grasping end tube. A position limiting protrusion is disposed inside the lower portion of the grasping end tube. The grasping end for a frog-style forceps does not need to align relatively small positioning protrusions with a slot on a screw seat, so that it is convenient and easy to assemble and very easy to dismantle the grasping end.