Patents by Inventor Xiulan Sun
Xiulan Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240076706Abstract: MLX1034 is from Polaribacter sp. Q13, and has the amino acid sequence of the 1,3/1,4-xylanase MLX1034 is listed in SEQ ID NO.1; a nucleotide sequence of the gene is listed in SEQ ID NO.2; the 1,3/1,4-xylanase MLX1034 in the invention is capable of efficiently and specifically degrading 1,3/1,4-xylan and producing xylooligosaccharides with DP values above one; in addition, the physical and chemical properties of the 1,3/1,4-xylanase MLX1034 are stable enough to hydrolyze 1,3/1,4-xylan at room temperature; the 1,3/1,4-xylanase MLX1034 is suitable for the industrial production of red algal xylooligosaccharides at low energy costs.Type: ApplicationFiled: December 7, 2021Publication date: March 7, 2024Applicant: SHAN DONG UNIVERSITYInventors: Yuzhong ZHANG, Fang ZHAO, Xiulan CHEN, Haining SUN, Xiaoyan SONG, Pingyi LI
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Patent number: 11655208Abstract: The present disclosure discloses a 1-carboxy-2-hydroxy-3-iminopropane and an extraction method thereof, and belongs to the technical fields of food, health food and medicine.Type: GrantFiled: December 13, 2021Date of Patent: May 23, 2023Assignee: JIANGNAN UNIVERSITYInventors: Xiulan Sun, Yongli Ye, Qianqian Hong, Deping Xu, Yinzhi Zhang, Shuxiang Geng
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Patent number: 11612878Abstract: The present disclosure belongs to the technical field of analytical chemistry, in particular to synthesis and application of a nanomaterial for removal of patulin (Pat). The present disclosure adopts 2-Oxin as a substitute template, AM as a functional monomer, and synthetic Fe3O4@SiO2@CS-GO magnetic nanoparticles as a carrier, for preparing a magnetic MIP specific for Pat adsorption by surface imprinting. The addition of Fe3O4 makes the finally prepared molecular imprinted adsorbent material magnetic, thereby facilitating separation of a material from a matrix, eliminating complicated operation steps such as filtration and centrifugation, and facilitating recovery of materials.Type: GrantFiled: July 11, 2019Date of Patent: March 28, 2023Assignee: JIANGNAN UNIVERSITYInventors: Xiulan Sun, Yongli Ye, Jian Ji, Fuwei Pi, Yinzhi Zhang, Wei Guo, Xueqing Shan
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Publication number: 20230081132Abstract: The present invention discloses a time-resolved immunoquantitation test strip for detecting tetrodotoxin (TTX) in shellfish food, which belongs to the technical field of rapid detection of time-resolved immunoassay. In the present invention, fluorescent microspheres are adopted to replace the traditional colloidal gold; the fluorescent microsphere is used for labeling a TTX antibody complex; by utilizing a competitive immunization method, the fluorescent microsphere, serving as a fluorescent probe, is used for immunochromatography; and by reading the fluorescence value of a detection line on a fluoroimmunoassay instrument, the TTX in shellfish samples can be analyzed quantitatively and rapidly. The time-resolved immunoquantitation test strip of the present invention can be used for detecting the content of the TTX in various types of shellfish food quantitatively and rapidly and is strong in specificity and high in sensitivity, wherein when the concentration of the TTX is 0.Type: ApplicationFiled: August 10, 2022Publication date: March 16, 2023Applicant: Jiangnan UniversityInventors: Yongli YE, Xiulan SUN, Zhixuan SHI, Jiadi SUN, Jian JI, Yinzhi ZHANG
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Publication number: 20220308005Abstract: The disclosure provides a single-cell-based electrochemical sensor based on a functionalized nano-probe and an application thereof, and belongs to the technical fields of electrochemical sensors and toxin detection. The single-cell-based electrochemical sensor of the disclosure combines a nano-probe and an electrochemical cell-based sensor, conducts functional modification on the nano-probe using Prussian blue, and conducts current signal analysis on a single cell by a micro-operating platform. The disclosure constructs a reliable, easy to operate and highly repeatable single-cell-based electrochemical detection platform, and the current value is determined by electrochemical chronoamperometry to determine damage of a single cell stimulated by toxins, thereby quickly and effectively evaluating the cytotoxicity of fungal toxins, and further enabling application of the fungal toxin toxicity in real-time monitoring and nano-environmental detection in living cells.Type: ApplicationFiled: June 16, 2022Publication date: September 29, 2022Inventors: Yongli YE, Xiulan SUN, Jiadi SUN, Liping WANG, Jian JI, Yinzhi ZHANG, Lu GAO
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Patent number: 11384109Abstract: The disclosure discloses a method for separating phenolic acid glucoside compounds from Diaphragma juglandis Fructus, belonging to the technical field of food. The method includes the following steps: (1) extraction: crushing Diaphragma juglandis Fructus, and then extracting by using ethanol to obtain walnut ethanol extract; and (2) separation: performing column chromatography on the walnut ethanol extract obtained in step (1), sequentially eluting by using ethanol of different concentrations, purifying and eluting repeatedly, and performing separation to obtain phenolic acid glucoside compounds. The phenolic acid glucoside compounds are 2-hydroxyl-5-methoxylphenyl-O-?-D-glucopyranoside, 6-hydroxylnaphthyl-1,2-di-O-?-D-glucopyranoside and 2,6-dihydroxynaphthyl-O-?-D-glucopyranoside. Pharmacological experiments confirm that the three compounds have good antioxidant activity.Type: GrantFiled: October 21, 2021Date of Patent: July 12, 2022Assignee: Jiangnan UniversityInventors: Xiulan Sun, Yida Xu, Deping Xu, Yinzhi Zhang
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Publication number: 20220098144Abstract: The present disclosure discloses a 1-carboxy-2-hydroxy-3-iminopropane and an extraction method thereof, and belongs to the technical fields of food, health food and medicine.Type: ApplicationFiled: December 13, 2021Publication date: March 31, 2022Inventors: Xiulan SUN, Qianqian HONG, Deping XU, Yinzhi ZHANG, Shuxiang GENG
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Patent number: 11279079Abstract: The disclosure relates to a cell electrochemical sensor based on a 3D printing technology and application thereof and belongs to the technical field of electrochemical sensors and toxin detection. The cell electrochemical sensor of the disclosure is constructed based on a 3D printing technology, and the construction method comprises the following steps: precisely depositing a cell/carbon nanofiber/GelMA composite hydrogel on a working electrode of a screen-printed carbon electrode through 3D printing, and carrying out curing to obtain the cell electrochemical sensor. The disclosure constructs a cell electrochemical sensor with a three-dimensional cell growth environment and rapid and sensitive response. The cell electrochemical sensor constructed by the disclosure can be used for quickly and effectively determining the combined effect type and effect degree of deoxynivalenol family toxins by combining an electrochemical impedance method and a combination index method.Type: GrantFiled: September 28, 2020Date of Patent: March 22, 2022Assignee: Jiangnan UniversityInventors: Xiulan Sun, Jiadi Sun, Jian Ji, Yinzhi Zhang, Kaimin Wei
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Publication number: 20220041639Abstract: The disclosure discloses a method for separating phenolic acid glucoside compounds from Diaphragma juglandis Fructus, belonging to the technical field of food. The method includes the following steps: (1) extraction: crushing Diaphragma juglandis Fructus, and then extracting by using ethanol to obtain walnut ethanol extract; and (2) separation: performing column chromatography on the walnut ethanol extract obtained in step (1), sequentially eluting by using ethanol of different concentrations, purifying and eluting repeatedly, and performing separation to obtain phenolic acid glucoside compounds. The phenolic acid glucoside compounds are 2-hydroxyl-5-methoxylphenyl-O-?-D-glucopyranoside, 6-hydroxylnaphthyl-1,2-di-O-?-D-glucopyranoside and 2,6-dihydroxynaphthyl-O-?-D-glucopyranoside. Pharmacological experiments confirm that the three compounds have good antioxidant activity.Type: ApplicationFiled: October 21, 2021Publication date: February 10, 2022Inventors: Xiulan Sun, Yida Xu, Deping Xu, Yinzhi Zhang
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Publication number: 20210147288Abstract: The disclosure discloses a high-flux and ultra-sensitive detection dot array enhancement chip, and belongs to the field of food safety detection. In the disclosure, single-layer Au nano-particles are chemically bonded onto a hydrophilic substrate, an Au nano-material is naturally deposited in holes of the chip under an electrostatic adsorption action, and a regular dot array is formed. Au particles distributed in the holes are separated with a particle surfactant (CTAB) to form plasma gaps so as to enhance the self-assemble of Au nano-particles distributed on hot-spots for a long range effect, thereby improving the sensing signal in detection efficiency and sensitivity of the chip.Type: ApplicationFiled: October 9, 2020Publication date: May 20, 2021Inventors: Fuwei PI, Ling LIU, Ying LI, Yuanyuan ZHANG, Ziye YIN, Yuliang CHENG, Lin LIN, Xiulan SUN
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Publication number: 20210023770Abstract: The disclosure relates to a cell electrochemical sensor based on a 3D printing technology and application thereof and belongs to the technical field of electrochemical sensors and toxin detection. The cell electrochemical sensor of the disclosure is constructed based on a 3D printing technology, and the construction method comprises the following steps: precisely depositing a cell/carbon nanofiber/GelMA composite hydrogel on a working electrode of a screen-printed carbon electrode through 3D printing, and carrying out curing to obtain the cell electrochemical sensor. The disclosure constructs a cell electrochemical sensor with a three-dimensional cell growth environment and rapid and sensitive response. The cell electrochemical sensor constructed by the disclosure can be used for quickly and effectively determining the combined effect type and effect degree of deoxynivalenol family toxins by combining an electrochemical impedance method and a combination index method.Type: ApplicationFiled: September 28, 2020Publication date: January 28, 2021Inventors: Xiulan SUN, Jiadi SUN, Jian JI, Yinzhi ZHANG, Kaimin WEI
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Publication number: 20210003565Abstract: The disclosure relates to a zearalenone-deoxynivalenol dual-channel immunoquantitative test strip and belongs to the technical field of immunoassay rapid detection. The disclosure prepares fluorescent probes by labeling with fluorescent microspheres, including a fluorescent microsphere-zearalenone monoclonal antibody, a fluorescent microsphere-deoxynivalenol monoclonal antibody and a fluorescent microsphere-goat anti-mouse second antibody. A zearalenone artificial antigen, a fluorescent microsphere artificial antigen and a goat anti-mouse second antibody are respectively sprayed on a nitrocellulose membrane to serve as a detection line T1, a detection line T2 and a quality control line C to prepare the immunochromatographic test strip; a competitive immunoassay method is adopted, and zearalenone and deoxynivalenol in samples are quantitatively analyzed at the same time by reading fluorescence values of the detection lines on a fluorescence immunoanalyzer.Type: ApplicationFiled: August 12, 2020Publication date: January 7, 2021Inventors: Xiulan SUN, Jiadi SUN, Jian JI, Yinzhi ZHANG, Miao LI, Ying LIU
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Publication number: 20190329221Abstract: The present disclosure belongs to the technical field of analytical chemistry, in particular to synthesis and application of a nanomaterial for removal of patulin (Pat). The present disclosure adopts 2-Oxin as a substitute template, AM as a functional monomer, and synthetic Fe3O4@SiO2@CS-GO magnetic nanoparticles as a carrier, for preparing a magnetic MIP specific for Pat adsorption by surface imprinting. The addition of Fe3O4 makes the finally prepared molecular imprinted adsorbent material magnetic, thereby facilitating separation of a material from a matrix, eliminating complicated operation steps such as filtration and centrifugation, and facilitating recovery of materials.Type: ApplicationFiled: July 11, 2019Publication date: October 31, 2019Inventors: Xiulan SUN, Jian JI, Fuwei PI, Yinzhi Zhang, Wei Guo, Xueqing Shan
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Patent number: 9891184Abstract: Dithienylpyrrole compounds, compositions containing dithienylpyrrole polymers, and methods for making the compounds and compositions are disclosed herein. The compositions containing dithienylpyrrole polymers, can for example, be used as conducting polymers in biosensors for detecting analytes in a sample.Type: GrantFiled: December 31, 2012Date of Patent: February 13, 2018Assignee: Jiangnan UniversityInventors: Zaijun Li, Qianfang Xia, Xiulan Sun, Junkang Liu, Guangli Wang, Zhiguo Gu
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Patent number: 9887046Abstract: An graphene composites have reduced graphene oxide and a layered double-hydroxide distributed on the reduced graphene oxide. The composites may also include nanopores formed within the reduced graphene oxide and micropores that may be formed by the reduced graphene oxide. The composites may exhibit superior electrical and/or absorbent properties. Capacitor devices and electrodes containing the composites are also disclosed, as well as methods and systems configured to make and use the composites.Type: GrantFiled: December 28, 2012Date of Patent: February 6, 2018Assignee: Jiangnan UniversityInventors: Zaijun Li, Tao Yan, Xiulan Sun, Junkang Liu, Guangli Wang, Zhiguo Gu
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Publication number: 20150346134Abstract: Dithienylpyrrole compounds, compositions containing dithienylpyrrole polymers, and methods for making the compounds and compositions are disclosed herein. The compositions containing dithienylpyrrole polymers, can for example, be used as conducting polymers in biosensors for detecting analytes in a sample.Type: ApplicationFiled: December 31, 2012Publication date: December 3, 2015Inventors: Zaijun Li, Qianfang Xia, Xiulan Sun, Junkang Liu, Guangli Wang, Zhiguo Gu
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Publication number: 20150340171Abstract: An graphene composites have reduced graphene oxide and a layered double-hydroxide distributed on the reduced graphene oxide. The composites may also include nanopores formed within the reduced graphene oxide and micropores that may be formed by the reduced graphene oxide. The composites may exhibit superior electrical and/or absorbent properties. Capacitor devices and electrodes containing the composites are also disclosed, as well as methods and systems configured to make and use the composites.Type: ApplicationFiled: December 28, 2012Publication date: November 26, 2015Inventors: Zaijun Li, Tao Yan, Xiulan Sun, Junkang Liu, Guangli Wang, Zhiguo Gu
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Patent number: 8512700Abstract: The invention provides an effective and environmentally friendly antibody protective agent and the methods of using it in immunological detection. The antibody protective agent helps antibody to maintain relatively high immunological activity at room temperature. Working electrodes coated with antibodies and the antibody protective agent are installed in immunological detection devices to enhance stability and accuracy of immunological detection. The antibody protective agent is effectively used in the detection of a variety of toxins, for example, aflatoxin, staphylococcal enterotoxin, algae toxin, and vomitoxin.Type: GrantFiled: July 31, 2010Date of Patent: August 20, 2013Assignees: Jiangnan University, Wuxi Center for Disease Control and PreventionInventors: Xiulan Sun, Yinzhi Zhang, Zaijun Li, Jingping Zhang, Weimin Niu
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Publication number: 20110262626Abstract: The invention provides an effective and environmentally friendly antibody protective agent and the methods of using it in immunological detection. The antibody protective agent helps antibody to maintain relatively high immunological activity at room temperature. Working electrodes coated with antibodies and the antibody protective agent are installed in immunological detection devices to enhance stability and accuracy of immunological detection. The antibody protective agent is effectively used in the detection of a variety of toxins, for example, aflatoxin, staphylococcal enterotoxin, algae toxin, and vomitoxin.Type: ApplicationFiled: July 31, 2010Publication date: October 27, 2011Inventors: Xiulan Sun, Jingping Zhang, Weimin Niu, Yinzhi Zhang, Zaijun Li