Patents by Inventor Xiuling CHI

Xiuling CHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Integration sites and uses thereof
    Patent number: 11959093
    Abstract: The present disclosure provides compositions and methods for enhanced expression of exogenous genes in eukaryotic cells. The method involves introducing into a mammalian cell an exogenous nucleic acid. wherein the exogenous nucleic acid intearates into a locus of the genome that comprises an extended methylation-free CpG island. Also provided are chromosomal loci, sequences for enhanced and stable expression of exogenous genes.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: April 16, 2024
    Assignee: APPLIED STEMCELL, INC.
    Inventors: Ling-Jie Kong, Ruby Yanru Tsai, Xiuling Chi
  • HLA-F-MODIFIED CELLS AND METHODS
    Publication number: 20230233610
    Abstract: The present disclosure provides compositions and methods for cell transplantation therapy based on forced expression of an exogenous HLA-F protein in donor cells to be transplanted into a subject. In some embodiments, the donor cells express an exogenous chimeric HLA-F protein comprising an extracellular region comprising an HLA-F alpha 1 domain, an HLA alpha 2 domain, an HLA-F alpha 3 domain, a linker and a ?2m protein.
    Type: Application
    Filed: February 9, 2023
    Publication date: July 27, 2023
    Inventors: Ruby Yanru TSAI, Alfonso FARRUGGIO, Xiuling CHI, Kai WANG
  • HLA-F-MODIFIED CELLS AND METHODS
    Publication number: 20230049040
    Abstract: The present disclosure provides compositions and methods for cell transplantation therapy based on forced expression of an exogenous HLA-F protein in donor cells to be transplanted into a subject. In some embodiments, the donor cells express an exogenous chimeric HLA-F protein comprising an extracellular region comprising an HLA-F alpha 1 domain, an HLA alpha 2 domain, an HLA-F alpha 3 domain, a linker and a ?2m protein.
    Type: Application
    Filed: February 24, 2022
    Publication date: February 16, 2023
    Inventors: Ruby Yanru TSAI, Alfonso FARRUGGIO, Xiuling CHI, Kai WANG
  • COAGULATION FACTOR VIII MIMETIC PROTEIN AND USES THEREOF
    Publication number: 20210284715
    Abstract: The present disclosure provides a coagulation factor VIII(FVII) mimetic protein. The FVIII mimetic protein comprises (1) a coagulating factor IX (FIX/FIXa) binding domain comprising a first heavy chain variable region (VHI) and a first light chain variable region (VL1), wherein the VH1 and the VL1 are derived from an antibody specifically binding to FIX/FIXa; (2) a coagulation factor X (FX) binding domain comprising a second heavy chain variable region (VH2) and a second light chain variable region (VL2), wherein the VH2 and the VL2 are derived from an antibody specifically binding to FX; and (3) a membrane binding domain.
    Type: Application
    Filed: February 6, 2018
    Publication date: September 16, 2021
    Inventors: Ling-jie KONG, Ruby Yanru TSAI, Xiuling CHI
  • NOVEL INTEGRATION SITES AND USES THEREOF
    Publication number: 20200017884
    Abstract: The present disclosure provides compositions and methods for enhanced expression of exogenous genes in eukaryotic cells. Also provided are chromosomal loci, sequences for enhanced and stable expression of exogenous genes.
    Type: Application
    Filed: March 14, 2018
    Publication date: January 16, 2020
    Inventors: Ling-jie KONG, Ruby Yanru TSAI, Xiuling CHI