Abstract: Provided herein is a multispecific antibody containing two antigen binding arms capable of binding to a first target and at least one antigen binding arm capable of binding to a second target. The multispecific antibody includes a lambda charge pair introduced into the interface of a heavy chain and a light chain to reduce chain mispairing.

Abstract: Provided herein are trispecific antibodies containing three antigen binding arms each capable of binding to a different target, wherein each antigen binding arm contains a different lambda or kappa charge pair introduced into the interface of the respective heavy and light chains to reduce chain mispairing.

Abstract: Disclosed are a display panel and a display apparatus, wherein the display panel includes a plurality of first signal lines extending along a first direction and a plurality of pixel units arranged in an array in the first direction and a second direction; at least one pixel unit among the plurality of pixel units includes a component group and a drive chip configured to drive the component group to emit light; the component group includes K light emitting elements, and the drive chip includes K signal channel terminals, K is a positive integer greater than or equal to 2; for a pixel unit in a j-th row and an i-th column, cathodes of the K light emitting elements are electrically connected with an i-th first signal line, and an anode of an s-th light emitting element is electrically connected with an s-th signal channel terminal of the drive chip.

Abstract: The present disclosure provides compositions and methods for cell transplantation therapy based on forced expression of an exogenous HLA-F protein in donor cells to be transplanted into a subject. In some embodiments, the donor cells express an exogenous chimeric HLA-F protein comprising an extracellular region comprising an HLA-F alpha 1 domain, an HLA alpha 2 domain, an HLA-F alpha 3 domain, a linker and a ?2m protein.

Abstract: The present invention provides a preparation method of (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine or a salt thereof, which uses 4-fluoro-3-methylphenol as the starting material, and is carried out through the steps of bromination, O-alkylation, cyclization, bromination, azidation or ammonolysis, and reduction. The reaction route of the present invention has simple synthesis process, convenient operation, high yield, and is environmentally friendly. The prepared (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine can be used as an intermediate in pharmaceuticals and fine chemicals.

Abstract: The present disclosure relates to the technical field of microorganisms and fermentation, and specifically discloses a Lactobacillus acidipiscis, a fermented soymilk, and a preparation method and use thereof. Lactobacillus acidipiscis HAU-FR7 is disclosed with a deposit number of CGMCC NO. 19253. The Lactobacillus acidipiscis HAU-FR7 is a facultative anaerobe that can reduce soy isoflavones, and the Lactobacillus acidipiscis HAU-FR7 can not only grow under aerobic conditions, but also convert daidzin and genistin distributed in the soymilk into DHD and DHG under aerobic conditions. Moreover, the Lactobacillus acidipiscis HAU-FR7 has stable conversion capacity, and solves the problem of shortage of facultative anaerobes in the research and development of soy functional foods. The DPPH radical-scavenging capacity of DHD and DHG is significantly higher than that of daidzein and genistein.

Abstract: A one-part, self-etching dental adhesive is disclosed. The adhesive includes a hydrolytically stable acidic adhesive monomer and a hydrolytically stable, difunctional hydrophilic monomer.

Abstract: A one-part, self-etching dental adhesive is disclosed. The adhesive includes a hydrolytically stable acidic adhesive monomer and a hydrolytically stable, difunctional hydrophilic monomer.

Abstract: Two-part and one-part self-etching dental adhesives containing polymerizable acidic monomers. Methods include one-coat application without need for tooth etching.

Abstract: Two-part and one-part self-etching dental adhesives containing polymerizable acidic monomers. Methods include one-coat application without need for tooth etching.

Abstract: Two-part and one-part self-etching dental adhesives containing polymerizable acidic monomers. Methods include one-coat application without need for tooth etching.

Abstract: Two-part and one-part self-etching dental adhesives containing polymerizable acidic monomers. Methods include one-coat application without need for tooth etching.

Abstract: Two-part and one-part self-etching dental adhesives containing polymerizable acidic monomers. Methods include one-coat application without need for tooth etching.

Abstract: A preferred embodiment of the invention provides a composition and method of treating dental metal. The composition includes a polymerizable aryl compound having at least one carboxylic acid group and at least one polymerizable group, and a polymerizable compound having at least one polymerizable group and at least one phosphorous containing group. A preferred composition includes at least 50 percent by weight of a volatile organic solvent, at least 15 percent by weight of one or more polymerizable acrylate compounds and an effective amount of a photoinitiator. At least a portion of the polymerizable compounds are multifunctional polymerizable compounds having at least three acrylate moieties. The polymerizable compounds are substantially soluble in the solvent. The composition is adapted to form a polymeric material which is adapted to adhere to metal and ceramics and to dentin. Compositions of the invention have superior adhesion to dental metals and tooth without separately acid etching dentin or enamel.

Abstract: A shade guide (10) has a base (11) and a plurality of indicia tabs (15) carried by stems (14). Base (11) also includes a shade calculation table (20) containing at least the necessary recipe components of a foundation, body and enamel layers (22, 23 and 24) to achieve the shade of a given tab (15).

Abstract: A method and material for forming translucent wear resistant dental enamel and the dental enamel material formed which has an opacity less than 50 percent and a localized wear volume loss of less than 0.025 mm3. The dental enamel material is formed from a polymerizable matrix and a filler. The material for forming translucent wear resistant dental enamel having an opacity less than 50 percent, a localized wear volume loss of less than 0.025 mm3 and a localized extended wear volume loss of less than 0.04 mm3, comprises a polymerizable matrix forming liquid and inorganic filler particles. The liquid comprises polymerizable material having a first refractive index. The filler comprising a first plurality of particles having a second refractive index. The first plurality of particles being formed from a low and a high median particle size plurality of particles. The low median particle size plurality of particles having a median particle size between 0.1 and 1.0 micrometers.