Patents by Inventor Xiuqing Zhang
Xiuqing Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240079509Abstract: A solar cell, a textured surface structure and a method for preparing the same are provided. The textured surface structure is formed on a surface of a silicon wafer, and the surface has a grid line covered area and a light-receiving exposure area. The textured surface structure includes a first textured surface formed on the grid line covered area, and a second textured surface formed on the light-receiving exposure area. The texture size of the first textured surface is larger than the texture size of the second textured surface.Type: ApplicationFiled: April 27, 2022Publication date: March 7, 2024Inventors: Lin SUN, Junlin DU, Gongbing CHEN, Lin ZHANG, Xiuqing YANG, Xiangfei LIU, Tao YAN, Deng PAN
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Publication number: 20230348856Abstract: A method for activating an adaptive immune response by adding allogeneic dendritic cells (DCs) and/or viral antigen peptides to conventional DC vaccines to expand the DC vaccine antigen spectrum with the aid of exogenous DC effect, thereby enhancing the anti-tumor effect of the DC vaccine.Type: ApplicationFiled: March 27, 2023Publication date: November 2, 2023Inventors: Yuping GE, Yaling HUANG, Zhengqi ZHAO, Xuan DONG, Ying GU, Yong HOU, Xiuqing ZHANG
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Publication number: 20230175938Abstract: Disclosed is an electro-magneto-thermo-mechanical dynamic and synchronous loading device based on a wedge-shaped rotating body. The device comprises a carrier, a wedge-shaped rotating body and a pulse power supply, wherein the wedge-shaped rotating body is positioned above the carrier, the pulse power supply is connected to the carrier and the wedge-shaped rotating body through conductors, a test object is fixed on the carrier, the top of the wedge-shaped rotating body is connected to the output end of a driving shaft through a transmission shaft, the driving shaft drives the wedge-shaped rotating body to rotate and can apply downward pressure, and the wedge-shaped rotating body can be pressed against the test object and rotate on the surface of the test object.Type: ApplicationFiled: November 21, 2022Publication date: June 8, 2023Applicant: Hefei Institutes of Physical Science, Chinese Academy of SciencesInventors: Liansheng Huang, Shiying He, Xiaojiao Chen, Xiuqing Zhang, Chuan Li
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Publication number: 20230160798Abstract: Disclosed is a synchronous and dynamic loading method in electro-magneto-thermo-mechanical multi-field coupling conditions. The method comprises the following steps: applying maximum pulse current to a test object by a pulse power supply to realize loading in extreme electric field and magnetic field conditions; meanwhile, generating a large amount of friction heat by the high-speed rotation of a rotating body and the friction of the test object to realize loading in an extreme-temperature field combined with a large amount of Joule heat and arc heat; synchronously applying pressure to the rotating body by a pressure device to realize loading of extreme force combined with the gravity of the rotating body and the friction force between the rotating body and the test object.Type: ApplicationFiled: November 21, 2022Publication date: May 25, 2023Applicant: Hefei Institutes of Physical Science, Chinese Academy of SciencesInventors: Liansheng Huang, Xiaojiao Chen, Shiying He, Xiuqing Zhang, Chuan Li
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Method for calculating maximum output current of multiple thyristor converters connected in parallel
Patent number: 11489454Abstract: A method for calculating a maximum output current of multiple thyristor converters connected in parallel, step 1: setting an operating time t; step 2: assuming a trigger angle; step 3: calculating a maximum output current of a single converter according to an output current model for the single converter; step 4: equally dividing a total output DC current into a plurality of parts according to a working duration of six converter bridge arms, thereby obtaining a pulse operating current of a single bridge arm; step 5: checking whether a present junction temperature of a thyristor is below a limiting temperature based on a thermal resistance model for the thyristor, if no, correcting the trigger angle, and repeating step 2 to step 5 until the condition is met; step 6: giving a present trigger angle; and step 7: giving a maximum output current of multiple converters connected in parallel.Type: GrantFiled: June 8, 2021Date of Patent: November 1, 2022Assignee: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCEInventors: Liansheng Huang, Zhongma Wang, Peng Fu, Shiying He, Xiaojiao Chen, Xiuqing Zhang, Tianbai Deng, Tao Chen, Zhenshang Wang -
Patent number: 11371074Abstract: Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method and the system have clinical feasibility, and can precisely detect a micro-deletion/micro-duplication area of 0.5 M under the situation of using data of about 50 M.Type: GrantFiled: January 29, 2018Date of Patent: June 28, 2022Assignee: BGI Genomics Co., Ltd.Inventors: Xuchao Li, Shengpei Chen, Fang Chen, Weiwei Xie, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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METHOD FOR CALCULATING MAXIMUM OUTPUT CURRENT OF MULTIPLE THYRISTOR CONVERTERS CONNECTED IN PARALLEL
Publication number: 20220060106Abstract: A method for calculating a maximum output current of multiple thyristor converters connected in parallel, step 1: setting an operating time t; step 2: assuming a trigger angle; step 3: calculating a maximum output current of a single converter according to an output current model for the single converter; step 4: equally dividing a total output DC current into a plurality of parts according to a working duration of six converter bridge arms, thereby obtaining a pulse operating current of a single bridge arm; step 5: checking whether a present junction temperature of a thyristor is below a limiting temperature based on a thermal resistance model for the thyristor, if no, correcting the trigger angle, and repeating step 2 to step 5 until the condition is met; step 6: giving a present trigger angle; and step 7: giving a maximum output current of multiple converters connected in parallel.Type: ApplicationFiled: June 8, 2021Publication date: February 24, 2022Inventors: Liansheng HUANG, Zhongma WANG, Peng FU, Shiying HE, Xiaojiao CHEN, Xiuqing ZHANG, Tianbai DENG, Tao CHEN, Zhenshang WANG -
Publication number: 20180320235Abstract: Provided are a method, system and computer readable medium for determining the base information in a predetermined area of a fetus genome, the method comprising following steps: constructing a sequence library for the DNA samples of the fetus genome; sequencing the sequence library to obtain the sequencing result of the fetus, the sequencing result of the fetus comprised of a plurality of sequencing data; and based on the sequencing result of the fetus, determining the base information in the predetermined area according to the hidden Markov model in conjunction with the genetic information of an individual related hereditarily to the fetus.Type: ApplicationFiled: July 19, 2018Publication date: November 8, 2018Inventors: Shengpei Chen, Huijuan Ge, Xuchao Li, Shang Yi, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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Publication number: 20180148765Abstract: Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method and the system have clinical feasibility, and can precisely detect a micro-deletion/micro-duplication area of 0.5 M under the situation of using data of about 50 M.Type: ApplicationFiled: January 29, 2018Publication date: May 31, 2018Inventors: Xuchao LI, Shengpei CHEN, Fang CHEN, Weiwei XIE, Jian WANG, Jun WANG, Huanming YANG, Xiuqing ZHANG
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Patent number: 9567633Abstract: A method for detecting hydroxymethylation modification in nucleic acid comprises: glycosylating the nucleic acid, digesting with MspI, ligating the digested fragments to a biotin-labeled linker at both ends thereof, digesting with NlaIII; capturing the digested fragments using streptavidin magnetic beads to produce fragments having the biotin-labeled linker at one end and a CATG 4-base sticky end at the other end, wherein these fragments reveal modification information of their adjacent CCGG sites; ligating the CATG sticky end to a linker containing a recognition site of MmeI or Ecop15I, digesting with corresponding restriction endonuclease to produce short sequence fragments that can reveal modification information of their adjacent CCGG sites; and performing a tag number comparison to obtain information about methylation and hydroxymethylation modification relative levels. A use of the method is also provided.Type: GrantFiled: November 21, 2012Date of Patent: February 14, 2017Assignee: BGI TECH SOLUTIONS CO., LTD.Inventors: Fei Gao, Junwen Wang, Xiuqing Zhang, Huanming Yang
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Patent number: 9547748Abstract: The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc.Type: GrantFiled: June 29, 2011Date of Patent: January 17, 2017Assignee: BGI HEALTH SERVICE CO., LTD.Inventors: Fuman Jiang, Huifei Chen, Xianghua Chai, Yuying Yuan, Xiuqing Zhang, Fang Chen
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Patent number: 9518295Abstract: The present invention provides a high-throughput sequencing method for methylated DNA, and use thereof. Particularly, the present invention provides a high-throughput sequencing method for methylated DNA, which combines methylated DNA immunoprecipitation, removal of repetitive sequences, and bisulfite treatment. The site of sequencing library will be decreased, and the cost will be reduced by using the method disclosed in the present invention.Type: GrantFiled: August 11, 2010Date of Patent: December 13, 2016Assignees: Institute of Psychology, Chinese Academy of Sciences, BGI Shenzhen Co., Ltd.Inventors: Yan Wang, Mingzhi Ye, Xu Han, Xiuqing Zhang, Zhongsheng Sun
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Patent number: 9359642Abstract: Provided are a method of constructing a nucleic acid library, a method of determining a nucleic acid sequence of a nucleic acid sample, and a kit thereof. The method of constructing the nucleic acid library includes the following steps: subjecting a nucleic acid sample to a DOP-PCR amplification, to obtain a first PCR amplification product; subjecting the first PCR amplification product to a second PCR amplification using a DOP-Amp primer, to obtain a second PCR amplification product; and subjecting the second PCR amplification product to an adaptor-ligation PCR, to obtain a third PCR amplification product, wherein the third PCR amplification product constitutes the nucleic acid library.Type: GrantFiled: October 16, 2012Date of Patent: June 7, 2016Assignees: BGI SHENZHEN CO., LIMITED, BGI SHENZHENInventors: Xuyang Yin, Chunlei Zhang, Hui Jiang, Xiuqing Zhang, Shengpei Chen
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Patent number: 9238840Abstract: A method for analyzing a genome of a single cell is provided, and a kit is also provided. The method for analyzing the genome of the single cell may comprise separating and lysing the single cell to obtain a whole-genome DNA of the cell; subjecting the whole-genome DNA to a whole-genome amplification to obtain a whole-genome amplification product; performing a PCR amplification using the whole-genome amplification product as template and using housekeeping-gene-specific primers to detect the housekeeping gene of the whole-genome amplification product; and determining whether the whole genome amplification product meets a requirement for sequencing based on the detection result, wherein a uniform distribution of the amplification product in each chromosome is an indication of the amplification product meeting the requirement for sequencing.Type: GrantFiled: December 29, 2011Date of Patent: January 19, 2016Assignee: BGI-Shenzhen Co., LimitedInventors: Xuyang Yin, Li Bao, Xun Xu, Hanjie Wu, Xiaoyu Liu, Xiuqing Zhang, Huanming Yang
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Publication number: 20150105264Abstract: Provided are a method and a system for identifying whether the twins are dizygotic twins, the method comprising: typing at least one polymorphic loci of the twins fetuses to obtain the fetal polymorphism types, comparing the fetal polymorphism types with the corresponding polymorphism types of their parents, determining whether the twins are dizygotic twins on the basis of the comparison result.Type: ApplicationFiled: May 23, 2012Publication date: April 16, 2015Applicant: BGI DIAGNOSIS CO., LTD.Inventors: Huijuan Ge, Jing Zheng, Shang Yi, Xuchao Li, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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Publication number: 20150094210Abstract: Provided are a method, system and computer readable medium for determining the base information in a predetermined area of a fetus genome, the method comprising following steps: constructing a sequence library for the DNA samples of the fetus genome; sequencing the sequence library to obtain the sequencing result of the fetus, the sequencing result of the fetus comprised of a plurality of sequencing data; and based on the sequencing result of the fetus, determining the base information in the predetermined area according to the hidden Markov model in conjunction with the genetic information of an individual related hereditarily to the fetus.Type: ApplicationFiled: May 14, 2012Publication date: April 2, 2015Applicant: BGI DIAGNOSIS CO., LTD.Inventors: Shengpei Chen, Huijuan Ge, Xuchao Li, Shang Yi, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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Publication number: 20150056619Abstract: Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method comprises obtaining reads; determining sequence labels according to the reads; counting the number of sequence labels falling into each window; performing GC correction on the sequence label number of each window and a correction according to an expected sequence label number adjusted by a control set to obtain a corrected sequence label number; selecting a demarcation point with a small significance value as a candidate CNV breaking point; rejecting the least significant candidate CNV breaking point at every turn, updating difference significance values of two candidate CNV breaking points on the left and right of the rejected candidate CNV breaking point and performing cyclic iteration until difference significance values of all candidate CNV breaking points are smaller than a termination threshold value, thereby determining a CNV breaking point.Type: ApplicationFiled: April 5, 2012Publication date: February 26, 2015Applicant: BGI DIAGNOSIS CO., LTD.Inventors: Xuchao Li, Shengpei Chen, Fang Chen, Weiwei Xie, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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Publication number: 20150031552Abstract: A method for detecting hydroxymethylation modification in nucleic acid comprises: glycosylating the nucleic acid, digesting with MspI, ligating the digested fragments to a biotin-labeled linker at both ends thereof, digesting with NlaIII; capturing the digested fragments using streptavidin magnetic beads to produce fragments having the biotin-labeled linker at one end and a CATG 4-base sticky end at the other end, wherein these fragments reveal modification information of their adjacent CCGG sites; ligating the CATG sticky end to a linker containing a recognition site of MmeI or Ecop15I, digesting with corresponding restriction endonuclease to produce short sequence fragments that can reveal modification information of their adjacent CCGG sites; and performing a tag number comparison to obtain information about methylation and hydroxymethylation modification relative levels. A use of the method is also provided.Type: ApplicationFiled: November 21, 2012Publication date: January 29, 2015Inventors: Fei Gao, Junwen Wang, Xiuqing Zhang, Huanming Yang
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Publication number: 20150012252Abstract: Provided are a method, system, and computer-readable medium for determining whether a copy number variation exists in a sample genome. The method includes sequencing a sample genome to obtain a sequencing result formed by multiple reads; comparing the sequencing result with a reference genome sequence to determine the distribution of the reads on the reference genome sequence; determining, based on the distribution of the reads on the reference genome sequence, multiple breakpoints on the reference genome sequence, wherein the number of the reads on either side of each breakpoint are significantly different; determining, based on the plurality of breakpoints, a detection window on the reference genome; determining, based on the reads falling in the detection window, a parameter; and determining, based on the difference between the first parameter and a preset threshold, whether a copy number variation exists in the sample genome against the detection window.Type: ApplicationFiled: January 20, 2012Publication date: January 8, 2015Applicant: BGI Diagnosis Co., Ltd.Inventors: Xuyang Yin, Chunlei Zhang, Shengpei Chen, Chunsheng Zhang, Xiaoyu Pan, Hui Jiang, Xiuqing Zhang
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Publication number: 20140370504Abstract: The present invention relates to a method for detecting genetic variation, comprising the following steps: acquiring reads from a test sample; aligning said reads with a reference genome sequence; dividing said reference genome sequence into windows, calculating the number of said reads which are aligned to each window, and acquiring the statistic for each window on the basis of the number of said reads; and for a fragment of the reference genome sequence, acquiring the genetic variation sites on the basis of the change in the statistics of all the windows thereon in the fragment of the reference genome sequence.Type: ApplicationFiled: December 31, 2011Publication date: December 18, 2014Applicant: BGI DIAGNOSIS CO., LTD.Inventors: Shengpei Chen, Chunlei Zhang, Fang Chen, Weiwei Xie, Xiaoyu Pan, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang