Abstract: A dynamic measurement method for spatial magnetic field of transmission lines based on two-dimensional electromagnetic sensor matrix is provided. Data measured by an electromagnetic sensor matrix parallel to the transmission lines is used to calibrate an unmanned aerial vehicle (UAV) flight status, while magnetic field distribution characteristics within a profile of the transmission lines are measured using an electromagnetic sensor matrix perpendicular to the transmission lines, thereby achieving dynamic measurement of the spatial magnetic field of the transmission lines during UAV flight. The method achieves measurement of the magnetic field distribution characteristics within the vertical profile of the transmission lines while ensuring that the UAV flies parallel to the transmission lines.

Abstract: An adaptive IGBT active drive circuit is divided into two parts: a gate drive circuit, and a feedback circuit. The gate drive circuit includes a totem pole unit, and multi-level resistance switching is achieved by using a totem pole parallel structure. The feedback circuit includes a comparison unit, and a logic unit. The comparison unit includes divided resistors, sampling resistors, and a comparator. Internal currents, after passing through the sampling resistor, are compared with current comparison thresholds of complementary transistors to output a digital signal to participate in control of the totem pole. The logic unit is responsible for logically combining a PWM signal and a signal output by the comparison unit to obtain a driving signal of the totem pole.

Abstract: Disclosed is a synchronous and dynamic loading method in electro-magneto-thermo-mechanical multi-field coupling conditions. The method comprises the following steps: applying maximum pulse current to a test object by a pulse power supply to realize loading in extreme electric field and magnetic field conditions; meanwhile, generating a large amount of friction heat by the high-speed rotation of a rotating body and the friction of the test object to realize loading in an extreme-temperature field combined with a large amount of Joule heat and arc heat; synchronously applying pressure to the rotating body by a pressure device to realize loading of extreme force combined with the gravity of the rotating body and the friction force between the rotating body and the test object.

Abstract: Disclosed is an electro-magneto-thermo-mechanical dynamic and synchronous loading device based on a wedge-shaped rotating body. The device comprises a carrier, a wedge-shaped rotating body and a pulse power supply, wherein the wedge-shaped rotating body is positioned above the carrier, the pulse power supply is connected to the carrier and the wedge-shaped rotating body through conductors, a test object is fixed on the carrier, the top of the wedge-shaped rotating body is connected to the output end of a driving shaft through a transmission shaft, the driving shaft drives the wedge-shaped rotating body to rotate and can apply downward pressure, and the wedge-shaped rotating body can be pressed against the test object and rotate on the surface of the test object.

Abstract: A method for activating an adaptive immune response by adding allogeneic dendritic cells (DCs) and/or viral antigen peptides to conventional DC vaccines to expand the DC vaccine antigen spectrum with the aid of exogenous DC effect, thereby enhancing the anti-tumor effect of the DC vaccine.

Abstract: Disclosed is an electro-magneto-thermo-mechanical dynamic and synchronous loading device based on a wedge-shaped rotating body. The device comprises a carrier, a wedge-shaped rotating body and a pulse power supply, wherein the wedge-shaped rotating body is positioned above the carrier, the pulse power supply is connected to the carrier and the wedge-shaped rotating body through conductors, a test object is fixed on the carrier, the top of the wedge-shaped rotating body is connected to the output end of a driving shaft through a transmission shaft, the driving shaft drives the wedge-shaped rotating body to rotate and can apply downward pressure, and the wedge-shaped rotating body can be pressed against the test object and rotate on the surface of the test object.

Abstract: Disclosed is a synchronous and dynamic loading method in electro-magneto-thermo-mechanical multi-field coupling conditions. The method comprises the following steps: applying maximum pulse current to a test object by a pulse power supply to realize loading in extreme electric field and magnetic field conditions; meanwhile, generating a large amount of friction heat by the high-speed rotation of a rotating body and the friction of the test object to realize loading in an extreme-temperature field combined with a large amount of Joule heat and arc heat; synchronously applying pressure to the rotating body by a pressure device to realize loading of extreme force combined with the gravity of the rotating body and the friction force between the rotating body and the test object.

Abstract: A method for calculating a maximum output current of multiple thyristor converters connected in parallel, step 1: setting an operating time t; step 2: assuming a trigger angle; step 3: calculating a maximum output current of a single converter according to an output current model for the single converter; step 4: equally dividing a total output DC current into a plurality of parts according to a working duration of six converter bridge arms, thereby obtaining a pulse operating current of a single bridge arm; step 5: checking whether a present junction temperature of a thyristor is below a limiting temperature based on a thermal resistance model for the thyristor, if no, correcting the trigger angle, and repeating step 2 to step 5 until the condition is met; step 6: giving a present trigger angle; and step 7: giving a maximum output current of multiple converters connected in parallel.

Abstract: Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method and the system have clinical feasibility, and can precisely detect a micro-deletion/micro-duplication area of 0.5 M under the situation of using data of about 50 M.

Abstract: A method for calculating a maximum output current of multiple thyristor converters connected in parallel, step 1: setting an operating time t; step 2: assuming a trigger angle; step 3: calculating a maximum output current of a single converter according to an output current model for the single converter; step 4: equally dividing a total output DC current into a plurality of parts according to a working duration of six converter bridge arms, thereby obtaining a pulse operating current of a single bridge arm; step 5: checking whether a present junction temperature of a thyristor is below a limiting temperature based on a thermal resistance model for the thyristor, if no, correcting the trigger angle, and repeating step 2 to step 5 until the condition is met; step 6: giving a present trigger angle; and step 7: giving a maximum output current of multiple converters connected in parallel.

Abstract: Provided are a method, system and computer readable medium for determining the base information in a predetermined area of a fetus genome, the method comprising following steps: constructing a sequence library for the DNA samples of the fetus genome; sequencing the sequence library to obtain the sequencing result of the fetus, the sequencing result of the fetus comprised of a plurality of sequencing data; and based on the sequencing result of the fetus, determining the base information in the predetermined area according to the hidden Markov model in conjunction with the genetic information of an individual related hereditarily to the fetus.

Abstract: Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method and the system have clinical feasibility, and can precisely detect a micro-deletion/micro-duplication area of 0.5 M under the situation of using data of about 50 M.

Abstract: A method for detecting hydroxymethylation modification in nucleic acid comprises: glycosylating the nucleic acid, digesting with MspI, ligating the digested fragments to a biotin-labeled linker at both ends thereof, digesting with NlaIII; capturing the digested fragments using streptavidin magnetic beads to produce fragments having the biotin-labeled linker at one end and a CATG 4-base sticky end at the other end, wherein these fragments reveal modification information of their adjacent CCGG sites; ligating the CATG sticky end to a linker containing a recognition site of MmeI or Ecop15I, digesting with corresponding restriction endonuclease to produce short sequence fragments that can reveal modification information of their adjacent CCGG sites; and performing a tag number comparison to obtain information about methylation and hydroxymethylation modification relative levels. A use of the method is also provided.

Abstract: The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc.

Abstract: The present invention provides a high-throughput sequencing method for methylated DNA, and use thereof. Particularly, the present invention provides a high-throughput sequencing method for methylated DNA, which combines methylated DNA immunoprecipitation, removal of repetitive sequences, and bisulfite treatment. The site of sequencing library will be decreased, and the cost will be reduced by using the method disclosed in the present invention.

Abstract: Provided are a method of constructing a nucleic acid library, a method of determining a nucleic acid sequence of a nucleic acid sample, and a kit thereof. The method of constructing the nucleic acid library includes the following steps: subjecting a nucleic acid sample to a DOP-PCR amplification, to obtain a first PCR amplification product; subjecting the first PCR amplification product to a second PCR amplification using a DOP-Amp primer, to obtain a second PCR amplification product; and subjecting the second PCR amplification product to an adaptor-ligation PCR, to obtain a third PCR amplification product, wherein the third PCR amplification product constitutes the nucleic acid library.

Abstract: A method for analyzing a genome of a single cell is provided, and a kit is also provided. The method for analyzing the genome of the single cell may comprise separating and lysing the single cell to obtain a whole-genome DNA of the cell; subjecting the whole-genome DNA to a whole-genome amplification to obtain a whole-genome amplification product; performing a PCR amplification using the whole-genome amplification product as template and using housekeeping-gene-specific primers to detect the housekeeping gene of the whole-genome amplification product; and determining whether the whole genome amplification product meets a requirement for sequencing based on the detection result, wherein a uniform distribution of the amplification product in each chromosome is an indication of the amplification product meeting the requirement for sequencing.

Abstract: Provided are a method and a system for identifying whether the twins are dizygotic twins, the method comprising: typing at least one polymorphic loci of the twins fetuses to obtain the fetal polymorphism types, comparing the fetal polymorphism types with the corresponding polymorphism types of their parents, determining whether the twins are dizygotic twins on the basis of the comparison result.

Abstract: Provided are a method, system and computer readable medium for determining the base information in a predetermined area of a fetus genome, the method comprising following steps: constructing a sequence library for the DNA samples of the fetus genome; sequencing the sequence library to obtain the sequencing result of the fetus, the sequencing result of the fetus comprised of a plurality of sequencing data; and based on the sequencing result of the fetus, determining the base information in the predetermined area according to the hidden Markov model in conjunction with the genetic information of an individual related hereditarily to the fetus.

Abstract: Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method comprises obtaining reads; determining sequence labels according to the reads; counting the number of sequence labels falling into each window; performing GC correction on the sequence label number of each window and a correction according to an expected sequence label number adjusted by a control set to obtain a corrected sequence label number; selecting a demarcation point with a small significance value as a candidate CNV breaking point; rejecting the least significant candidate CNV breaking point at every turn, updating difference significance values of two candidate CNV breaking points on the left and right of the rejected candidate CNV breaking point and performing cyclic iteration until difference significance values of all candidate CNV breaking points are smaller than a termination threshold value, thereby determining a CNV breaking point.