Patents by Inventor Xiuzhen Zhang

Xiuzhen Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS
    Publication number: 20230241241
    Abstract: This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.
    Type: Application
    Filed: June 19, 2020
    Publication date: August 3, 2023
    Applicant: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Robert ZHAO, Qingliang YANG, Hangbo YE, Yuanyuan HUANG, Yifang XU, Gengxiang ZHAO, Diancheng CHEN, Huihui GUO, Xiangfei KONG, Wenjun LI, Lu BAI, Xiang CAI, Xiuzhen ZHANG, Junxiang JIA, Zhixiang GUO, Shangma HUANG, Xiaoxu WANG, Jun ZHENG, Yong DU, Yanhua LI, Yunxia ZHENG, Chen LIN, Xiaoxiao CHEN, Wei ZHENG, Xinyan JIANG, Lingli ZHANG, Riping YE, Miaomiao CHEN
  • A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS
    Publication number: 20230115871
    Abstract: The present invention relates to the conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.
    Type: Application
    Filed: June 24, 2019
    Publication date: April 13, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Linyao ZHAO, Yuanyuan HUANG, Hangbo YE, Shun GAI, Junxiang JIA, Lu BAI, Wenjun LI, Zhixiang GUO, Chen LIN, Jun ZHENG, Huihui GUO, Minjun CAO, Xiangfei KONG, Yong DU, Yifang XU, Xiaomai ZHOU, Hongsheng XIE, Xiuzhen ZHANG, Miaomiao CHEN, Xiaolei LIU, Xiang CAI, Binbin CHEN, Yanlei YANG, Lingli ZHANG
  • A FORMULATION OF A CONJUGATE OF A TUBULYSIN ANALOG TO A CELL-BINDING MOLECULE
    Publication number: 20220249594
    Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
    Type: Application
    Filed: February 18, 2020
    Publication date: August 11, 2022
    Applicant: HANGZHOU DAC BIOTECH CO., LTD
    Inventors: Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Huihui GUO, Lu BAI, Wenjun LI, Junxiang JIA, Zhixiang GUO, Jun ZHENG, Xiaoxiao CHEN, Xiangfei KONG, Chen LIN, Yong DU, Yu ZHANG, Lei ZHOU, Xiuzhen ZHANG, Xiuhong ZHENG, Binbin CHEN, Yanlei YANG, Meng DAI, Yifang XU, Zhongliang FAN, Xiaomai ZHOU, Xingyan JIANG, Miaomiao CHEN, Lingli ZHANG, Yanhua LI
  • Method and apparatus for classification of data by aggregating emerging patterns
    Patent number: 6507843
    Abstract: Emerging patterns (EPs) are itemsets having supports that change significantly from one dataset to another. A classifier, CAEP, is disclosed using the following main ideas based on EPs: (i) Each EP can sharply differentiate the class membership of a (possibly small) fraction of instances containing the EP, due to the big difference between the EP's supports in the opposing classes; the differentiating power of the EP is defined in terms of the EP's supports and ratio, on instances containing the EP. (ii) For each instance t, by aggregating (124) the differentiating power of a fixed, automatically selected set of EPs, a score is obtained for each class (126). The scores for all classes are normalized (144) and the largest score determines t's class (146). CAEP is suitable for many applications, even those with large volumes of high dimensional data. CAEP does not depend on dimension reduction on data and is usually equally accurate on all classes even if their populations are unbalanced.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: January 14, 2003
    Assignee: Kent Ridge Digital Labs
    Inventors: Guozhu Dong, Jinyan Li, Limsoon Wong, Xiuzhen Zhang