Patents by Inventor Xiuzheng ZHANG

Xiuzheng ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS
    Publication number: 20230165931
    Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: January 19, 2023
    Publication date: June 1, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Shun GAI, Hangbo YE, Jun LEI, Yifang XU, Mingjun CAO, Huihui GUO, Junxiang JIA, Qianqian TONG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Lu BAI, Xiang CAI, Xiaotao ZHUO, Xiuzheng ZHANG, Jun ZHENG
  • CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS
    Publication number: 20230165930
    Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: January 19, 2023
    Publication date: June 1, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Shun GAI, Hangbo YE, Jun LEI, Yifang XU, Mingjun CAO, Huihui GUO, Junxiang JIA, Qianqian TONG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Lu BAI, Xiang CAI, Xiaotao ZHUO, Xiuzheng ZHANG, Jun ZHENG
  • CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS
    Publication number: 20230149502
    Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: January 19, 2023
    Publication date: May 18, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Shun GAI, Hangbo YE, Jun LEI, Yifang XU, Mingjun CAO, Huihui GUO, Junxiang JIA, Qianqian TONG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Lu BAI, Xiang CAI, Xiaotao ZHUO, Xiuzheng ZHANG, Jun ZHENG
  • A CONJUGATE OF AN AMANITA TOXIN WITH BRANCHED LINKERS
    Publication number: 20230057350
    Abstract: Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: January 31, 2019
    Publication date: February 23, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Jun LEI, Yuanyuan HUANG, Linyao ZHAO, Hangbo YE, Shun GAI, Mingjun CAO, Qianqian TONG, Lu BAI, Zhixiang GUO, Chengyu YANG, Xiaomai ZHOU, Hongsheng XIE, Yifang XU, Huihui GUO, Junxiang JIA, Jun ZHENG, Cheng LIN, Xiaotao ZHUO, Wenjun LI, Yong DU, Xiangfei KONG, Binbin CHEN, Yanlei YANG, Yanhong TONG, Xiaoxiao CHEN, Yanhua LI, Xiuzheng ZHANG, Juan LAI
  • A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS
    Publication number: 20200276261
    Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: December 31, 2017
    Publication date: September 3, 2020
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Shun GAI, Hangbo YE, Jun LEI, Yifang XU, Mingjun CAO, Huihui GUO, Junxiang JIA, Qianqian TONG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Lu BAI, Xiang CAI, Xiaotao ZHUO, Xiuzheng ZHANG, Jun ZHENG