Patents by Inventor Xiuzhi Zhan

Xiuzhi Zhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Linker for antibody-drug conjugates and its use
    Patent number: 12195552
    Abstract: The present invention provides a linker for preparing antibody-drug conjugates and antibody-drug conjugates prepared by the linker, as well as use of the antibody-drug conjugates in a medicament for treating tumor. The linker is capable of coupling simultaneously with the thiol group or amino group on the antibody or functional fragment of the antibody, especially it is capable of coupling with 2, 3 or 4 thiol groups on the antibody or functional fragment of the antibody. A coupled product is uniform and structurally stable.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: January 14, 2025
    Assignee: RemeGen Co., Ltd.
    Inventors: Changjiang Huang, Hui Ye, Hu Chen, Xiuzhi Zhan, Nan Shen, Wenting Luo, Qiaohua Hou, Jianmin Fang
  • LINKER FOR ANTIBODY-DRUG CONJUGATES AND ITS USE
    Publication number: 20220072137
    Abstract: The present invention provides a linker for preparing antibody-drug conjugates and antibody-drug conjugates prepared by the linker, as well as use of the antibody-drug conjugates in a medicament for treating tumor. The linker is capable of coupling simultaneously with the thiol group or amino group on the antibody or functional fragment of the antibody, especially it is capable of coupling with 2, 3 or 4 thiol groups on the antibody or functional fragment of the antibody. A coupled product is uniform and structurally stable.
    Type: Application
    Filed: December 13, 2019
    Publication date: March 10, 2022
    Applicant: RemeGen Co., Ltd.
    Inventors: Changjiang Huang, Hui Ye, Hu Chen, Xiuzhi Zhan, Nan Shen, Wenting Luo, Qiaohua Hou, Jianmin Fang