Abstract: The present invention provides a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound of formula (I), as well as the use and method for preventing or treating FLT3-related conditions, especially conditions related to mutant FLT3 kinase (particularly, FLT3/ITD mutant kinase).

Abstract: The present application provides a compound of Formula (I) as an inhibitor against wild-type EGFR and/or mutant EGFR, which may be used for treating human non-small cell lung cancer individually or in combination with other therapeutic agent(s). The compound of Formula (I) of the present application may be used for treating patients of drug-resistant human non-small cell lung cancer harboring wild-type EGFR and/or EGFR T790M mutation and/or EGFR L858R mutation and/or EGFR delE746_A750 mutation.

Abstract: The present invention provides a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound of formula (I), as well as the use and method for preventing or treating FLT3-related conditions, especially conditions related to mutant FLT3 kinase (particularly, FLT3/ITD mutant kinase).

Abstract: Provided in the present invention is a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. Also provided in the present invention are a pharmaceutical composition comprising a compound of formula (I) and a use and method for preventing or treating cell proliferative conditions and/or FLT3-related conditions, in particular for conditions responding to the inhibition of FLT3 kinase (especially FLT3/ITD mutant kinases).

Abstract: The present application provides a compound of Formula (I) as an inhibitor against wild-type EGFR and/or mutant EGFR, which may be used for treating human non-small cell lung cancer individually or in combination with other therapeutic agent(s). The compound of Formula (I) of the present application may be used for treating patients of drug-resistant human non-small cell lung cancer harboring wild-type EGFR and/or EGFR T790M mutation and/or EGFR L858R mutation and/or EGFR delE746_A750 mutation.

Abstract: Provided in the present invention is a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. Also provided in the present invention are a pharmaceutical composition comprising a compound of formula (I) and a use and method for preventing or treating cell proliferative conditions and/or FLT3-related conditions, in particular for conditions responding to the inhibition of FLT3 kinase (especially FLT3/ITD mutant kinases).

Abstract: In a data transmission system, a route information header RIH is added in each transmitted data packet and includes the route information of the data packet in a network. A network element receives the data packet, reads out route information which is needed by a node, and transmits the data packet after the network element reads out the route information which is needed by the node. the route information can be deleted from RIH, and a verification field of the RIH can be updated. The system includes an existing network and a data relay network device, and a data encapsulation protocol of the relay network device for the RIH is associated with the service layer of the original data encapsulation protocol, or is associated with the same layer as an original data encapsulation protocol. The original data encapsulation protocol is used for transmitting in a data relay network device supporting RIH, or is terminated at a boundary of the data relay device at network.

Abstract: A method of rate-control for a group of ports in a communication network. Ramping is performed for allowed-rate of each of the group of ports, if sum of the ingress-rates of the group of ports is less than a given rate threshold; and adjusting is performed for allowed-rate of each of the group of ports, if sum of the ingress-rates of the group of ports is greater than or equal to the given rate threshold, such that the sum of allowed-rates of the group of ports is equal to the given rate threshold.

Abstract: An apparatus and a method for realizing OAM function interworking between an Ethernet network and an MPLS network in network communication field. The method meets the challenge in realizing OAM functions when MPLS serves as a bearer network to bear Ethernet services, provides processing modes for all kinds of OAM functions. Based on the Ethernet-MPLS service interworking function model defined in Y.1415, interworking of Ethernet OAM functions defined in Y.17 ethoam and MPLS OAM functions defined in Y.1711 on network layer is realized, ensuring an end-to-end OAM interworking mechanism between Ethernet and MPLS networks. Processing modes for all kinds of OAM functions on the basis of the Ethernet-MPLS service interworking model in Y.1415 are provided, implementing end-to-end OAM interworking and improving communication continuity and safety between the Ethernet network and the MPLS network.

Abstract: A method for protecting a network comprising a first network element, which homes to a second network element and a third network element on the same ring network, the method comprising the steps of: establishing and transporting on the second network element a service from the first network element to the second network element, and detecting the status of the service; sending a switching message to the third network element upon detection of a failure of the service between the first network element and the second network element; and establishing and transporting a service as failed from the first network element to the second network element by the third network element, by using network resource of the ring network assigned on the second network element for the failed service prior to the failure of the service, in response to the switching message.

Abstract: The present invention provides a method and device for protective switching of pseudo-wires on a Packet Switching Network. The method includes grouping the pseudo-wires on the Packet Switching Network into a working pseudo-wire group and a protective pseudo-Wire group corresponding to each other's relationship of protection; performing on services the protective switching between the working pseudo-wire group and the protective pseudo-wire group according to the state of the working pseudo-wire group and protective pseudo-wire group. The method of the present invention can be used to perform edge-to-edge grouped protective switching of the pseudo-wires on the Packet Switching Network.

Abstract: In a data transmission system, a route information header RIH is added in each transmitted data packet and includes the route information of the data packet in a network. A network element receives the data packet, reads out route information which is needed by a node, and transmits the data packet after the network element reads out the route information which is needed by the node. the route information can be deleted from RIH, and a verification field of the RIH can be updated. The system includes an existing network and a data relay network device, and a data encapsulation protocol of the relay network device for the RIH is associated with the service layer of the original data encapsulation protocol, or is associated with the same layer as an original data encapsulation protocol. The original data encapsulation protocol is used for transmitting in a data relay network device supporting RIH, or is terminated at a boundary of the data relay device at network.

Abstract: The present invention provides an apparatus and a method for realizing OAM function interworking between an Ethernet network and an MPLS network in network communication field. The method meets the challenge in realizing OAM functions when MPLS serves as a bearer network to bear Ethernet services, provides processing modes for all kinds of OAM functions. Based on the Ethernet-MPLS service interworking function model defined in Y.1415, the embodiments of the present invention realize interworking of Ethernet OAM functions defined in Y.17ethoam and MPLS OAM functions defined in Y.1711 on network layer, ensuring an end-to-end OAM interworking mechanism between Ethernet and MPLS networks. The embodiments of the present invention provide processing modes for all kinds of OAM functions on the basis of the Ethernet-MPLS service interworking model in Y.1415, implementing end-to-end OAM interworking and improving communication continuity and safety between the Ethernet network and the MPLS network.

Abstract: A method for protecting a network comprising a first network element, which homes to a second network element and a third network element on the same ring network, the method comprising the steps of: establishing and transporting on the second network element a service from the first network element to the second network element, and detecting the status of the service; sending a switching message to the third network element upon detection of a failure of the service between the first network element and the second network element; and establishing and transporting a service as failed from the first network element to the second network element by the third network element, by using network resource of the ring network assigned on the second network element for the failed service prior to the failure of the service, in response to the switching message.

Abstract: A method of rate-control for a group of ports in a communication network. Ramping is performed for allowed-rate of each of the group of ports, if sum of the ingress-rates of the group of ports is less than a given rate threshold; and adjusting is performed for allowed-rate of each of the group of ports, if sum of the ingress-rates of the group of ports is greater than or equal to the given rate threshold, such that the sum of allowed-rates of the group of ports is equal to the given rate threshold.