Patents by Inventor Xixuan LI

Xixuan LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sialidase inhibitors and preparation thereof
    Patent number: 11325936
    Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: May 10, 2022
    Assignee: The Regents of the University of California
    Inventors: Xi Chen, An Xiao, Wanqing Li, Xixuan Li, Yanhong Li, Teri Slack
  • SIALIDASE INHIBITORS AND PREPARATION THEREOF
    Publication number: 20200190130
    Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Inventors: Xi CHEN, An XIAO, Wanqing LI, Xixuan LI, Yanhong LI, Teri SLACK