Patents by Inventor Xiying SHANG

Xiying SHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL-TARGETED CYTOTOXIC CONSTRUCTS
    Publication number: 20240229003
    Abstract: The invention is directed to cell-targeted cytotoxic agents, including sortase serine protease constructs. Methods for targeted cell killing for treatment of proliferative diseases, for example, cancer, are provided. Exemplary embodiments comprise an R-spondin ligand for targeting the cytotoxic agents to effect the cell killing.
    Type: Application
    Filed: January 29, 2024
    Publication date: July 11, 2024
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Xinjian LIN, Xiying SHANG, Stephen B. HOWELL
  • Cell-targeted cytotoxic constructs
    Patent number: 11913043
    Abstract: The invention is directed to cell-targeted cytotoxic agents, including sortase serine protease constructs. Methods for targeted cell killing for treatment of proliferative diseases, for example, cancer, are provided. Exemplary embodiments comprise an R-spondin ligand for targeting the cytotoxic agents to effect the cell killing.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: February 27, 2024
    Assignee: Research Development Foundation
    Inventors: Xinjian Lin, Xiying Shang, Stephen B. Howell
  • CELL-TARGETED CYTOTOXIC CONSTRUCTS
    Publication number: 20220267752
    Abstract: Cell-targeted cytotoxic agents, including sortase serine protease constructs, are provided. Such compounds can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant sortase serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity.
    Type: Application
    Filed: November 4, 2021
    Publication date: August 25, 2022
    Applicant: Research Development Foundation
    Inventors: Xinjian LIN, Xiying SHANG, Stephen B. HOWELL
  • Cell-targeted cytotoxic constructs
    Patent number: 11193117
    Abstract: The present invention is directed generally to cell-targeted cytotoxic constructs comprising a targeting polypeptide, a linking polypeptide and a cytotoxic polypeptide. Preferably, (a) the targeting polypeptide is a R-spondin1 (RSPO1), R-spondin2 (RSPO2) or yoked chorionic gonadotropin (YCG), the linking polypeptide comprises LPXT (SEQ ID NO: 56) or NPXT (SEQ ID NO: 60) as well as others, where X is any amino acid, the linking polypeptide being positioned between the targeting ligand and (c) the cytotoxic moiety is an auristatin or a truncated serine protease, the serine protease having an IIGG (SEQ ID NO: 91), IVGG (SEQ ID NO: 92) or ILGG (SEQ ID NO: 93) at its N-terminus. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer).
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: December 7, 2021
    Assignee: Research Development Foundation
    Inventors: Xinjian Lin, Xiying Shang, Stephen B. Howell
  • SORTASE-MODIFIED MOLECULES AND USES THEREOF
    Publication number: 20170260517
    Abstract: Cell-targeted cytotoxic agents, including sortase serine protease constructs, are provided. Such compounds can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant sortase serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity.
    Type: Application
    Filed: February 16, 2017
    Publication date: September 14, 2017
    Applicant: Research Development Foundation
    Inventors: Xinjian LIN, Xiying SHANG, Stephen B. HOWELL