Abstract: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.

Abstract: The application classification method includes: An electronic device obtains a first touch operation performed on a first folder on a display interface, where the first folder is any folder on the display interface, and the first folder includes at least one first application; and the electronic device displays at least one second application around the first folder in response to the first touch operation, where the at least one second application is an application that is in a third application and whose degree of matching the first folder is greater than a threshold, and the third application is an application that is not included in any folder on the display interface. According to the application classification method, an application that matches the first folder is displayed around the first folder, so that a user can quickly select an application that the user wants to store in the first folder.

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.

Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.

Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.

Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.

Abstract: An image reconstruction method includes: determining singles rates of radiation detectors in a frame of imaging data detected by the radiation detectors; determining an energy correction factor (Nwgt) for each radiation detector based on an energy spectrum distribution of gamma rays incident on the radiation detector during acquisition of the frame of imaging data; determining a singles live time correction factor for each radiation detector from the singles rate and the energy correction factor; determining a system coincidence live time correction factor from the system singles rate; for each line of response (LOR) connecting pairs of radiation detectors, determining a live time correction factor for the LOR from the determined singles live time correction factors of the pair of radiation detectors connected by the LOR and the determined system coincidence live time correction factor; and reconstructing the frame of imaging data using the determined LOR live time correction factors.

Abstract: The present application provides a cloud service method, an electronic device and a computer-readable storage medium. The method includes: receiving, by a multi-cloud gateway of a local cloud, a cloud service request, where the cloud service request carries a request source address, a request ontology, an address of a target cloud service, and an address of a local cloud VPC; sending, by the multi-cloud gateway of the local cloud, the cloud service request to a multi-cloud gateway of a remote cloud according to pre-stored routing information of the target cloud service corresponding to the address of the target cloud service; receiving, by the multi-cloud gateway of the local cloud, the target data sent by the multi-cloud gateway of the remote cloud, and sending the target data to the request source address.

Abstract: A non-transitory computer-readable medium stores instructions readable and executable by a workstation (18) including at least one electronic processor (20) to perform an imaging method (100). The method includes: receiving imaging data on a frame by frame basis for frames along an axial direction with neighboring frames overlapping along the axial direction wherein the frames include at least a volume (k) and a succeeding volume (k+1) at least partially overlapping the volume (k) along the axial direction; and generating an image of the volume (k) using an iterative image reconstruction process in which an iteration of the iterative image reconstruction process includes: computing a local penalty function for suppressing noise over the volume (k) including reducing the value of the local penalty function in an overlap region; generating an update image of the volume (k) using imaging data from the volume (k) and further using the local penalty function.

Abstract: An Tangible User Interface (TUI) authoring system is disclosed that allows end-users to customize edges on daily objects as TUI inputs to control varied digital functions. The TUI application authoring system incorporates an integrated AR-device and an integrated vision-based detection pipeline that can track 3D edges and detect the touch interaction between fingers and edges. Leveraging the spatial-awareness of AR, users can simply select an edge by sliding fingers along it and then make the edge interactive by connecting it to various digital functions. The system is demonstrated using four exemplary use cases including multi-function controllers, smart homes, games, and TUI-based tutorials.

Abstract: The present invention relates to variant xylanase enzymes and their use thereof.

Abstract: Systems and methods improving a target property of a target protein are provided. Each single point mutation in a first plurality of single point mutations of the target protein is obtained, each defining a corresponding single point substituted protein with respect to a reference sequence. A set of values for a set of properties of each point substituted protein is used to filter the first plurality of single point mutations into a reduced second plurality of single point mutations. The second plurality of mutations informs the selection of combinatorially substituted proteins and the target property is measured for each of them. The combinatorially substituted proteins and their measured values serve to train a surrogate model that, in turn, serves to update a search model. The updated search mode informs on which of the second plurality point mutations are to be used in future mutants of the target protein.

Abstract: Disclosed is a flame brazing control method for copper-aluminum welding, characterized by using a flame generated from the combustion of natural gas, air and oxygen as the heat source, the molar flow ratio of natural gas, air and oxygen is controlled within a range of 1:10-22:0.3-2.2. Further disclosed is an automatic brazing apparatus for copper-aluminum welding, characterized by using a flame generated from the combustion of natural gas, air and oxygen as the heat source, includes three gas delivery systems for natural gas, air and oxygen, a mixer for mixing the three gas, and integrated flow controllers for the electromagnetic valves and flow valves in the three gas delivery systems.

Abstract: The invention is directed to novel variant endoglucanases and their use thereof.

Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.

Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.

Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.