Patents by Inventor Xiyun Zhang

Xiyun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
    Publication number: 20190055536
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Application
    Filed: October 31, 2018
    Publication date: February 21, 2019
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
    Publication number: 20190040377
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Application
    Filed: October 22, 2018
    Publication date: February 7, 2019
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20190024059
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: October 5, 2018
    Publication date: January 24, 2019
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Biocatalysts and methods for hydroxylation of chemical compounds
    Patent number: 10184117
    Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: January 22, 2019
    Assignee: Codexis, Inc.
    Inventors: Jovana Nazor, Robert Osborne, Jack Liang, Jonathan Vroom, Xiyun Zhang, David Entwistle, Rama Voladri, Ravi David Garcia, Jeffrey C. Moore, Shane Grosser, Birgit Kosjek, Matthew Truppo
  • NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20190002847
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 3, 2019
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Engineered phenylalanine ammonia lyase polypeptides
    Patent number: 10160963
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: December 25, 2018
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • Engineered phenylalanine ammonia lyase polypeptides
    Patent number: 10144924
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: December 4, 2018
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • ENONE REDUCTASES
    Publication number: 20180312815
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Application
    Filed: June 28, 2018
    Publication date: November 1, 2018
    Inventors: Christopher K. Savile, Vesna Mitchell, Xiyun Zhang, Gjalt W. Huisman
  • P450-BM3 variants with improved activity
    Patent number: 10113153
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: October 30, 2018
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20180298355
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: June 26, 2018
    Publication date: October 18, 2018
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • P450-BM3 variants with improved activity
    Patent number: 10100289
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: October 16, 2018
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Lactonase enzymes and methods of using same
    Patent number: 10081800
    Abstract: Novel lactonases are provided.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: September 25, 2018
    Assignee: Fornia BioSolutions, Inc.
    Inventors: Goutami Banerjee, Jie Yang, Khin Oo, Xiyun Zhang, Eric Lin Hu, Tatsuya Fukushima
  • G16 glucoamylase compositions and methods
    Patent number: 10053678
    Abstract: The invention is directed to novel glucoamylases.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: August 21, 2018
    Assignee: Fornia BioSolutions, Inc.
    Inventors: Xiyun Zhang, Jie Yang, Goutami Banerjee, Khin Oo, Yingxin Zhang
  • Imidazoyl anilide derivatives and methods of use
    Patent number: 10045987
    Abstract: The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides nilotinib analogs that provide therapeutic benefits.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: August 14, 2018
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Jed Lee Hubbs, Xiyun Zhang, Robert Osborne
  • Enone reductases
    Patent number: 10035988
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: July 31, 2018
    Assignee: Codexis, Inc.
    Inventors: Christopher K. Savile, Vesna Mitchell, Xiyun Zhang, Gjalt W. Huisman
  • G24 glucoamylase compositions and methods
    Patent number: 10035997
    Abstract: The invention is directed to variant glucoamylases as compared to SEQ ID NO:1, including amino acid substitutions at positions including 24, 32, 47, 71, 75, 88, 102, 104, 114, 118, 190, 201, 204, 260, 228, 230, 269, 271, 272, 281, 283, 284, 285, 293, 350, 313, 321, 338, 343, 367, 371, 386, 372, 401, 408, 420, 448, 463, 483, 484, 507, 530, 563 599 and 605 that retain glucoamylase activity.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: July 31, 2018
    Assignee: Fornia BioSolutions, Inc.
    Inventors: Jie Yang, Goutami Banerjee, Xiyun Zhang, Khin Oo, Yingxin Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20180201911
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: March 6, 2018
    Publication date: July 19, 2018
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • PENICILLIN-G ACYLASES
    Publication number: 20180201919
    Abstract: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 19, 2018
    Inventors: Goutami Banerjee, Jie Yang, Xiyun Zhang, Erika M. Milczek, Melissa Ann Mayo, Stephan Jenne
  • Polynucleotides encoding transaminase polypeptides
    Patent number: 9944909
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: April 17, 2018
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • Penicillin-G acylases
    Patent number: 9944916
    Abstract: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: April 17, 2018
    Assignee: Codexis, Inc.
    Inventors: Goutami Banerjee, Jie Yang, Xiyun Zhang, Erika M. Milczek, Melissa Ann Mayo, Stephan Jenne