Abstract: The disclosure relates to the battery field and a PEO film, a preparation method thereof, and a solid-state battery are provided. A molecular structure of the PEO film includes a structural unit B, and the structural unit B includes —CH?CH—O—.

Abstract: The present disclosure relates to a distribution cable assembly that has various features to enable flexible configurations to accommodate various data center configurations.

Abstract: Disclosed is a massive data-driven method for automatically locating a mine microseismic source, including: constructing a microseismic wave calibration data set by using a large-scale seismic data set containing seismic signals and non-seismic signals; constructing a pre-training calibration model based on a full convolution neural network through deep learning of a seismic wave calibration data set; using microseismic data of mine sites for transfer learning of an initial arrival time calibration model to construct an arrival time automatic calibration model suitable for mine microseismic signals; and automatically as well as accurately locating mine microseismic events based on an isokinetic homogeneous isotropic velocity model by using an optimization algorithm to deduce arrival time errors and through repeated iteration and fine-tuning.

Abstract: In Provided herein are compositions and methods directed to treating, delaying progression of, or ameliorating symptoms related to disorders characterized with TGF-? activity (e.g., disorders characterized with aberrant cartilage formation and/or osteoclast resorption (e.g., ankylosing spondylitis)) (e.g., spinal cord injuries) (e.g., fibrotic scar formation following spinal cord injury) through inhibition of TGF-? activity (e.g., thereby hindering and/or inhibiting aberrant cartilage formation and/or osteoclast resorption within joints, muscles, tendons, ligaments, connective tissue, and/or bones experiencing or at risk of experiencing ankylosis) (e.g., thereby inhibiting fibrotic scar formation following spinal cord injury).

Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.

Abstract: The present invention shows that TGF-? is activated in tendon-bone insertion in both a semi-Achilles tendon transection (SMTS) mouse model and a dorsiflexion immobilization (DI) mouse model of enthesopathy. High concentrations of active TGF-? recruited mesenchymal stromal/stem cells (MSCs) and led to excessive vessel formation, bone deterioration and fibrocartilage calcification. The invention provides uses and methods for prophylaxis and treatment of enthesopathies by inhibition of TGF-?.

Abstract: A method for treating low back pain (LBP) and/or osteoarthritic pain in a subject in need of treatment thereof, the method comprising administering to the subject a composition comprising a recombinant parathyroid hormone (PTH) and a pharmaceutically acceptable carrier is disclosed.

Abstract: Provided herein are compositions and methods directed to treating, delaying progression of, or reducing cancer growth or metastasis, and the severity of disorders characterized with increased osteoclast activity through hindering and/or inhibiting osteoclastogenesis and/or osteoclast activity. In particular, the present invention provides compositions and methods directed to hindering and/or inhibiting Siglec15 and sialylated TLR (e.g., TLR2, TLR4) interaction by specific sialyltransferases.

Abstract: Detection of viral nucleic acids (NAs) and their variants is effected using nanopore technology. If the target wild type viral NA is single-stranded, it is mixed with its complementary NA, and also the unknown viral NA sample to be analyzed, followed by hybridization; while if the target wild type viral NA is double-stranded, it is mixed with the unknown viral NA sample only, then denatured and followed by hybridization. The hybridized products from either case are then subjected to translocation in the form of a translocation analysis, experiment or test through a nanopore device that measures the electrical signals induced through translocation events. The corresponding signal train is characteristic of an individual virus or variant and acts as a “fingerprint” facilitating rapid virus identification and discovery of a new variant.

Abstract: The present invention provides methods for manipulating epigenetic factors to treat pediatric or juvenile osteoporosis. Specifically, the present invention provides methods for the application of H3K27 demethylase inhibitors in pediatric or juvenile subjects with osteoporosis. Thus, the present invention provides methods of administration of the H3K27 demethylase inhibitor, GSK-J4, to pediatric or juvenile subjects to effectively inhibit primary and secondary pediatric osteoporosis, especially for long-term glucocorticoid treated patients (juvenile rheumatoid disorders, Crohn's disease, nephrotic syndrome, and Duchenne muscular dystrophy) and patients who have compromised mobility (cerebral palsy, Rett syndrome, Duchenne muscular dystrophy, spina bifida, and spinal muscular atrophy).

Abstract: An apparatus and method for user identity control are provided. The apparatus includes a communication unit, a storage unit including a unique ID and a plurality of sections, each section including different identity information, and a controller for, in response to a transaction request, transmitting a request for identity information to an authorization server via the communication unit, and for, in response to authorization information received from the authorization server, transmitting identity information to a third party to complete the transaction according to the received authorization information.

Abstract: A breast diffusion optical tomography (DOT) device includes a light source, a detector, a mechanical driver and a contour acquisitor without using optical fiber and reduce the system complexity. The light source includes M1 number of multi-wavelength near-infrared light emitters for a continuous-wave mode and M2 number of laser diodes of different wavelengths for a frequency-domain mode. The detector includes N1 number of silicon photomultipliers for detecting near-infrared light in the continuous-wave mode and N2 number of silicon photomultipliers for detecting near-infrared light in the frequency-domain mode. The mechanical driver adjusts a distance between the light source and the detector. The contour acquisitor obtains the geometry of a patient's breast for reconstruction. The DOT device uses amplitude and phase information obtained in the frequency-domain mode to estimate initial optical parameters of tissues and then apply for reconstruction in the continuous-wave mode.

Abstract: Provided herein are methods of treating, delaying progression of, or reducing the severity of metabolic disorders characterized with increased COX-2 expression and/or PGE2 expression and/or EP4 expression in bone related cells through administration of an agent configured to inhibit and/or diminish COX-2 expression, and/or PGE2 expression, and/or EP4 expression in bone related cells. In some embodiments, such administration results in one or more of the following: inhibited or reduced COX-2 expression; inhibited or reduced PGE2 expression; inhibited or reduced EP4 expression; inhibited or reduced aberrant subchondral bone remodeling and/or innervation; inhibited or reduced cartilage degeneration; and inhibited or reduced joint destruction.

Abstract: A two-by-two array consists of four pixels. Each pixel comprises one light-sensing transistor and one reading transistor. Both the light sensing transistor and the reading transistor are formed above a same P-type semiconductor substrate, and have a composite dielectric gate structure. The substrates of the four reading transistors are connected to form a regular octagonal ring structure located in the center of the array. On four sides of the regular octagonal ring structure, four heavily-doped N+ regions are formed on the substrates not covered with the composite dielectric gate, of which every two regions are opposite to each other and form right angles, wherein two opposite heavily-doped N+ regions are connected to form a shared N+ source, and the other two are connected to form a shared N+ drain.

Abstract: The present invention provides methods for treatment of IVD degeneration and/or LDD in a subject having symptoms of IVD degeneration and/or LDD comprising administering to the subject an effective amount of Parathyroid hormone (PTH) or a functional fragment or analog thereof. Reduction in IVD degeneration and regeneration of IVD using the inventive methods is also provided.

Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.

Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.

Abstract: The present inventors have uncovered the nature of heterotopic ossification HO progression as an excessive activation of TGF-? in recruitment of MSCs for osteogenesis in coupling with type H vessel formation. Systemic injection of TGF-? neutralizing antibody using the methods of the present invention, effectively attenuated HO progression in multiple different HO animal models. The present invention provides methods for prophylaxis and treatment of HO and also rare genetic diseases such as fibrodysplasia ossificans progressive (FOP) (also known as myositis ossificans progressive) and progressive osseous heteroplasia (POH).by inhibition of TGF-?.