Abstract: The present disclosure provides a shielding apparatus for a lower end of an injection needle and an injection device, and relates to the technical field of injection instruments. By using the shielding apparatus for a lower end of an injection needle in the present disclosure, in the process of mounting a needle holder on an insulin pen, and when the injection needle is completely removed from the insulin pen, the limit block also moves downwardly to abut against a bottom wall of the moving groove, and the shielding cylinder completely covers the lower end of the injection needle, so as to avoid a situation that a user accidentally touches the lower end of an injection needle to be injured, thereby avoiding the safety risk when the lower end of the injection needle is removed.

Abstract: The present disclosure provides a safe puncture needle, and relates to the technical field of medical devices, which comprises a needle holder, a base and a needle tubing, wherein the needle tubing comprises a needle tubing body and a needle tubing tip having a bent structure, the base comprises a base body and a guide block, the base body is provided with a second inner space, the base body is provided with a first through-hole and a second through-hole communicating with the second inner space, the guide block is provided with a third through-hole, the needle tubing body passes through the first through-hole and the third through-hole and is slidably connected to the guide block, and the needle tubing tip retracts from the second through-hole.

Abstract: A cabazitaxel weakly-alkaline derivative, preparation, and synthesis thereof, a liposome preparation containing the cabazitaxel weakly-alkaline derivative and application of the cabazitaxel weakly-alkaline derivative in a drug delivery system are provided. Cabazitaxel is connected with a weakly-alkaline intermediate through an ester bond, the ester bond can be broken under the action of esterase in vivo, and an active drug is released. A connecting group is C1-C4 alkyl, C3-C6 naphthenic base or phenyl; [N] is an N-methyl piperazinyl group, a piperidinyl group, a 4-(1-piperidinyl) piperidinyl group, a morpholinyl group, a pyrrolidine group or other tertiary amine structures. The cabazitaxel weakly-alkaline derivative can be prepared into the liposome preparation having high drug loading capacity, high encapsulation efficiency, and good stability.

Abstract: An apparatus is disclosed for providing frequency stabilization. The apparatus includes a first supply voltage node, a second supply voltage node, an oscillator circuit coupled to the first supply voltage node, at least one clock buffer coupled to the second supply voltage node and an output of the oscillator circuit, and at least one load circuit. The at least one clock buffer is configured to selectively be in a disabled state or an enabled state to pass the clock signal to at least one client of multiple clients. The at least one load circuit includes an input coupled to the output of the oscillator circuit. The at least one load circuit also includes an output configured to be coupled to a ground. The at least one load circuit is configured to be connected to the first supply voltage node for at least a portion of time.

Abstract: An apparatus is disclosed for providing frequency stabilization. The apparatus includes a first supply voltage node, a second supply voltage node, an oscillator circuit coupled to the first supply voltage node, at least one clock buffer coupled to the second supply voltage node and an output of the oscillator circuit, and at least one load circuit. The at least one clock buffer is configured to selectively be in a disabled state or an enabled state to pass the clock signal to at least one client of multiple clients. The at least one load circuit includes an input coupled to the output of the oscillator circuit. The at least one load circuit also includes an output configured to be coupled to a ground. The at least one load circuit is configured to be connected to the first supply voltage node for at least a portion of time.

Abstract: Methods, systems, and devices for wireless communication in a user equipment (UE) are described in which a cycle duration of an extended discontinuous reception (eDRX) cycle is determined. The UE enters a sleep state of the eDRX cycle and, based on the determination of the cycle duration, uses a first clock as a timer during the sleep state and uses a second clock as a timing calibrator during the sleep state. The first clock may have a lower power consumption and a higher frequency error, and the second clock may have a higher power consumption and a lower frequency error.

Abstract: Various embodiments of methods and systems for closed loop multimode sleep clock frequency compensation in a portable computing device are disclosed. An exemplary embodiment leverages a modem to determine a frequency shift on a sleep clock signal when a reference clock has transitioned into a power saving mode. Using the frequency shift calculation, a compensation capacitor may be adjusted to deliver a more optimum dummy load on the crystal oscillator when the reference clock is taken offline. The method may iterate through until the actual frequency shift of the sleep clock is within an acceptable tolerance relative to zero and, further, may also set a status bit to indicate that the sleep clock frequency is stable.