Abstract: A method for shape-performance control by ultrasonic rolling combined with selective laser melting is provided, which includes following steps: S1, establishing a three-dimensional model of a component to be processed, and setting printing process parameters; S2, after nitrogen gas is filled into a forming cavity to reduce an oxygen content to a preset value, lowering a forming substrate and raising a powder substrate, laying powder from the powder substrate onto the forming substrate by a scraper, recovering excess powder, and after the laying is completed, melting the powder by a laser galvanometer to form a solid layer, and cycling for several times; S3, performing ultrasonic rolling on a surface of the solid layer; S4, cycling steps S2 and S3 until the component is formed, and ending the cycling; and S5, performing ultrasonic rolling on a surface of a formed component to obtain a solid component.

Abstract: Provided are an anti-?Klotho antibody and the use thereof. The anti-?Klotho antibody can be used for treating ?Klotho-mediated or ?Klotho-FGFR1c-FGF21-mediated diseases, especially abnormal metabolic diseases, such as type 1 diabetes, type 2 diabetes, dyslipidemia, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, metabolic syndrome or obesity.

Abstract: A pressure sensor has a base layer, a supporting structure arranged on the base layer, and an elastic layer disposed above the base layer and the supporting structure. The elastic layer has a curved lower surface that is recessed away from the base layer. The curved lower surface, the supporting structure and the base layer define a cavity with an arched top wall. A first electrode, a second electrode, and an elastic body are all arranged within the cavity, such that when the elastic layer is elastically deformed in a direction of the base layer, the variable resistance elastic body electrically connects the first electrode with the second electrode, so as to generate a first signal related to the elastic deformation of the variable resistance elastic body.

Abstract: An apparatus for providing a switch mechanism comprises a housing and a pressure sensitive device mounted to the housing. An actuator is moveably connected to the housing to enable the actuator to move along an axis towards and away from the pressure sensitive device. A resilient member has a first end connected to the actuator and a second end connected to the pressure sensitive device.

Abstract: A pressure module comprises a substrate, a support structure and a pressing membrane. The support structure is connected to the substrate and the pressing membrane to form an accommodating cavity between the substrate and the pressing membrane. An electrode is disposed on a surface of the substrate or the pressing membrane and a variable resistance layer is respectively disposed on the opposite surface of the other of the substrate and the pressing membrane. On application of pressure to the pressing membrane, the pressing membrane is elastically deformed and the variable resistance layer is brought into contact with the electrode to form a contact area and a resistance value between the variable resistance layer and the electrode. The contact area and the elastic deformation is positively correlated.

Abstract: A button structure comprises a keycap, an elastic body, a scissor mechanism, and a piezoresistive film sensor arranged on a support plate. The scissor mechanism and the elastic body are arranged between the keycap and the piezoresistive film sensor. The piezoresistive film sensor comprises a first pressure sensing area and a second pressure sensing area. The elastic body corresponds to the first pressure sensing area and the scissor mechanism corresponds to the second pressure sensing area, such that, when a pressure is applied to the keycap, a first pressure acts on the elastic body to generate pressure on the first pressure sensing area and a second pressure acts on the scissor mechanism to generate pressure on the second pressure sensing area.

Abstract: An anti-GFRAL antibody and a use thereof. The anti-GFRAL antibody or an antigen-binding portion thereof can be used for treating or preventing GFRAL-mediated or GFRAL-RET-GDF15 signaling pathway-mediated diseases or abnormalities, particularly cachexia syndrome.

Abstract: The present disclosure provides a method for preparing a superhydrophobic surface of an aluminum alloy through laser peening, including the following steps: coating a surface of the aluminum alloy as an absorption layer with an organic component-containing confinement layer to obtain a coated aluminum alloy, where the organic component-containing confinement layer is a mixed organic solution including 5 mL to 10 mL of perfluorooctyltriethoxysilane (FOTS), 100 mL to 200 mL of absolute ethanol, and 30 mL to 50 mL of distilled water; and subjecting a surface of the coated aluminum alloy to the laser peening to form the superhydrophobic surface.

Abstract: An apparatus for use in the assembly of an electronic device, such as a mobile telephone, comprises a pressure sensor. The pressure sensor is embedded within an inner elastic layer and the inner elastic layer is embedded within an outer elastic layer. The inner elastic layer has an elastic modulus which is greater than the elastic modulus of the outer elastic layer.

Abstract: Provided is a method for determining an evolutionary primitive ancestry of Goji berry and use thereof, which relate to the field of species origin and genetic evolution. The method for determining an evolutionary primitive ancestry of Goji berry includes developing genome-wide molecular markers of Goji berries based on Specific-Locus Amplified Fragment Sequencing (SLAF-seq) technology, and determining the primitive ancestry of Goji berry through bioinformatic analysis. The selected Goji berries include not only wild Goji berries from Ningxia, Gansu, Qinghai, Xinjiang, Shaanxi, Inner Mongolia and Henan, but also Korean and Mexican Goji berry germplasms, with a wide range of sample sources, strong representation and large amount of information. The original ancestral genetic taxa of each Goji berry can be accurately determined through big data analysis. The gap in the origin and genetic evolution of Goji berry is thus fulfilled. The method has a good prospect in application.

Abstract: An electronic keyboard comprises a plurality of keys and a housing comprising a cavity. The cavity accommodates a circuit board, a pressing layer and at least one pressure sensor arranged therein. Each pressure sensor is provided between a lower portion of the cavity and the circuit board, the pressing layer is moveably connected to each of the keys and the circuit board is provided between the pressing layer and the lower portion. Each pressure sensor is connected to the circuit board, and a force-receiving surface of each pressure sensor aligns with a projection area of the corresponding one of the keys.

Abstract: The present disclosure provides a method for preparing a superhydrophobic surface of an aluminum alloy through laser peening, including the following steps: coating a surface of the aluminum alloy as an absorption layer with an organic component-containing confinement layer to obtain a coated aluminum alloy, where the organic component-containing confinement layer is a mixed organic solution including 5 mL to 10 mL of perfluorooctyltriethoxysilane (FOTS), 100 mL to 200 mL of absolute ethanol, and 30 mL to 50 mL of distilled water; and subjecting a surface of the coated aluminum alloy to the laser peening to form the superhydrophobic surface.

Abstract: Provided herein are safe harbor loci that can be utilized as sites for genetic modification. Safe harbor loci of the disclosure are shown to support sustained transgene expression with minimal silencing, and minimal impact on local or global gene expression. Safe harbor loci disclosed herein can be used in various genetic and cell engineering applications.

Abstract: The present invention relates to the field of bio-pharmaceuticals and, in particular, to an anti-Siglec-15 antibody or an antigen binding fragment thereof, a nucleic acid sequence encoding the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an expression vector containing the nucleic acid sequence, a host cell containing the expression vector, a composition or a bispecific antibody comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an immune conjugate comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof linked to a therapeutic agent, as well as use of the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof in the preparation of a medicament for treatment of cancer.

Abstract: A button structure has a base having a slot and a sensing element inserted into the slot. A pressure concentration element is fixedly connected by bonding to the sensing element and a key cap is mounted to the base. The key cap has a core member fixedly connected to a lower surface of a top plate of the key cap. The lower surface of the core member can be brought into contact with the pressure concentration element on application of a pressure to an upper surface of the top plate, such that the applied pressure is transmitted to the sensing element through the core member and the pressure concentration part. The sensing element is a piezoresistive film sensor.

Abstract: A key mechanism comprises an elastic structure comprising a first cavity located above a second cavity which are spaced apart from each other. The key mechanism comprises first and second button structures. The second button structure comprises an electrode layer on an upper wall of the second cavity and an electrode layer on a lower wall of the second cavity. The second button structure has an elastic body on the surface of one of the electrode layers. The first button structure is configured to generate a first key signal when a force is applied to an upper wall of the first cavity and compress the upper wall of the second cavity upon application of that force. The electrode layers come into contact to generate a second key signal in response to elastic deformation of the elastic body when the force is applied.

Abstract: A pressure sensor comprises a first sensing module comprising a first negative electrode and first support structures arranged at intervals on the first negative electrode. A first flexible insulating layer covers an upper surface of the first support structures and first positive electrodes are arranged at intervals on a lower surface of the first flexible insulating layer and distributed between the first support structures. A second sensing module comprises a second negative electrode disposed on the first flexible insulating layer and second support structures are arranged at intervals on the second negative electrode. A second flexible insulating layer covers an upper surface of the second support structures. Second positive electrodes are arranged on a lower surface of the second flexible insulating layer at intervals and distributed between the second support structures. The first support structures are offset from the second support structures.

Abstract: A touch pad, comprises a housing comprising a vibration device, a cover, a capacitive sensing layer electrically connected to a processor and a pressure sensing layer arranged in the housing, also electrically connected to the processor. The capacitive sensing layer is positioned between the cover and the pressure sensing layer. The processor is configured to utilize a signal output from either the capacitive sensing layer or the pressure sensing layer to activate the vibration device.

Abstract: An electronic keyboard comprises a plurality of keys and a housing comprising a cavity. The cavity accommodates a circuit board, a pressing layer and at least one pressure sensor arranged therein. Each pressure sensor is provided between a lower portion of the cavity and the circuit board, the pressing layer is moveably connected to each of the keys and the circuit board is provided between the pressing layer and the lower portion. Each pressure sensor is connected to the circuit board, and a force-receiving surface of each pressure sensor aligns with a projection area of the corresponding one of the keys.

Abstract: A touch device comprises a base, a membrane pressure sensor arranged on the base, a touch sensing layer covering the membrane pressure sensor, and a force feedback structure arranged on the lower surface of the touch sensing layer and electrically connected to the membrane pressure sensor. The membrane pressure sensor is configured to generate a pressing signal related to the force applied to it, and the force feedback structure is configured to receive the pressing signal and generate a feedback force corresponding to it.