Abstract: The present invention relates to the field of bio-pharmaceuticals and, in particular, to an anti-Siglec-15 antibody or an antigen binding fragment thereof, a nucleic acid sequence encoding the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an expression vector containing the nucleic acid sequence, a host cell containing the expression vector, a composition or a bispecific antibody comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an immune conjugate comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof linked to a therapeutic agent, as well as use of the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof in the preparation of a medicament for treatment of cancer.

Abstract: The present disclosure provides methods and devices for separation of motile sperm. A method of separating motile sperm comprises: introducing a fluid sample comprising motile sperm to an inlet portion of a microfluidic device; and causing the fluid sample to flow through a separation portion of the microfluidic device at a flow velocity within a rheotaxis range such that motile sperm in the sample undergo rheotaxis and remain in the separation whereas a part of the fluid sample flows out of the separation zone through an outlet portion of the microfluidic device.

Abstract: A resonant converter has a primary resonant tank circuit and a secondary resonant tank circuit. An inverter circuit converts an input DC voltage received by the resonant converter at an input voltage node to a pulsating signal that is fed to the primary resonant tank circuit to generate a resonant tank current that flows through a primary winding of a transformer. The resonant tank current induces current in a secondary winding of the transformer. The induced current is rectified by a rectifier and the rectified signal is filtered to generate an output DC voltage at an output voltage node. The secondary resonant tank circuit is disposed between the secondary winding of the transformer and the output voltage node, and a tank node of the secondary resonant tank is connected to the primary resonant tank circuit through the inverter circuit.

Abstract: A button structure has a base having a slot and a sensing element inserted into the slot. A pressure concentration element is fixedly connected by bonding to the sensing element and a key cap is mounted to the base. The key cap has a core member fixedly connected to a lower surface of a top plate of the key cap. The lower surface of the core member can be brought into contact with the pressure concentration element on application of a pressure to an upper surface of the top plate, such that the applied pressure is transmitted to the sensing element through the core member and the pressure concentration part. The sensing element is a piezoresistive film sensor.

Abstract: A key mechanism comprises an elastic structure comprising a first cavity located above a second cavity which are spaced apart from each other. The key mechanism comprises first and second button structures. The second button structure comprises an electrode layer on an upper wall of the second cavity and an electrode layer on a lower wall of the second cavity. The second button structure has an elastic body on the surface of one of the electrode layers. The first button structure is configured to generate a first key signal when a force is applied to an upper wall of the first cavity and compress the upper wall of the second cavity upon application of that force. The electrode layers come into contact to generate a second key signal in response to elastic deformation of the elastic body when the force is applied.

Abstract: A pressure sensor comprises a first sensing module comprising a first negative electrode and first support structures arranged at intervals on the first negative electrode. A first flexible insulating layer covers an upper surface of the first support structures and first positive electrodes are arranged at intervals on a lower surface of the first flexible insulating layer and distributed between the first support structures. A second sensing module comprises a second negative electrode disposed on the first flexible insulating layer and second support structures are arranged at intervals on the second negative electrode. A second flexible insulating layer covers an upper surface of the second support structures. Second positive electrodes are arranged on a lower surface of the second flexible insulating layer at intervals and distributed between the second support structures. The first support structures are offset from the second support structures.

Abstract: An electronic keyboard comprises a plurality of keys and a housing comprising a cavity. The cavity accommodates a circuit board, a pressing layer and at least one pressure sensor arranged therein. Each pressure sensor is provided between a lower portion of the cavity and the circuit board, the pressing layer is moveably connected to each of the keys and the circuit board is provided between the pressing layer and the lower portion. Each pressure sensor is connected to the circuit board, and a force-receiving surface of each pressure sensor aligns with a projection area of the corresponding one of the keys.

Abstract: A touch pad, comprises a housing comprising a vibration device, a cover, a capacitive sensing layer electrically connected to a processor and a pressure sensing layer arranged in the housing, also electrically connected to the processor. The capacitive sensing layer is positioned between the cover and the pressure sensing layer. The processor is configured to utilize a signal output from either the capacitive sensing layer or the pressure sensing layer to activate the vibration device.

Abstract: A touch device comprises a base, a membrane pressure sensor arranged on the base, a touch sensing layer covering the membrane pressure sensor, and a force feedback structure arranged on the lower surface of the touch sensing layer and electrically connected to the membrane pressure sensor. The membrane pressure sensor is configured to generate a pressing signal related to the force applied to it, and the force feedback structure is configured to receive the pressing signal and generate a feedback force corresponding to it.

Abstract: A button structure comprises a base layer, a supporting structure arranged on the base layer, an elastic film layer, the elastic film layer covering the support structure and connected to the support structure, the support structure and the elastic film layer defining a cavity above the base layer, a first upper electrode arranged on the lower surface of the elastic film layer and located in the cavity, a first lower electrode, arranged on the base layer and located in the cavity, and a first variable resistance elastic body between the first upper and first lower electrodes, either arranged on the lower surface of the first upper electrode or arranged on the upper surface of the first lower electrode. When the elastic film layer is elastically deformed in the direction of the base layer, the first variable resistance elastic body connects the first upper electrode with the first lower electrode so as to generate a first signal related to the elastic deformation of the first variable resistance elastic body.

Abstract: A pressure sensor comprises a base layer, a supporting structure arranged on the base layer, an elastic layer disposed above the base layer and the supporting structure, having a curved lower surface that is recessed away from the base layer, wherein the curved lower surface, the supporting structure and the base layer define a cavity with an arched top wall. A first electrode, a second electrode, and an elastic body are all arranged within the cavity, such that when the elastic layer is elastically deformed in the direction of the base layer, the elastic body electrically connects the first electrode with the second electrode, so as to generate a first signal related to the elastic deformation of the elastic body.

Abstract: An apparatus for use in the assembly of an electronic device, such as a mobile telephone, comprises a pressure sensor. The pressure sensor is embedded within an inner elastic layer and the inner elastic layer is embedded within an outer elastic layer. The inner elastic layer has an elastic modulus which is greater than the elastic modulus of the outer elastic layer.

Abstract: A button structure (708) comprises a base (709) comprising a slot (203) and a sensing element (710) inserted into the slot. A pressure concentration element (711) is fixedly connected to the sensing element and a key cap (712) is mounted to the base. The key cap comprises a core member (503) fixedly connected to a lower surface of a top plate (504) of the key cap. The core member comprises a lower surface (506) configured to be brought into contact with the pressure concentration element on application of a pressure to an upper surface of the top plate, such that the applied pressure is transmitted to the sensing element through the core member and the pressure concentration part.

Abstract: A pressure sensor comprises a first sensing module comprising a first negative electrode and first support structures arranged at intervals on the first negative electrode. A first flexible insulating layer covers an upper surface of the first support structures and first positive electrodes are arranged at intervals on a lower surface of the first flexible insulating layer and distributed between the first support structures. A second sensing module comprises a second negative electrode disposed on the first flexible insulating layer and second support structures are arranged at intervals on the second negative electrode. A second flexible insulating layer covers an upper surface of the second support structures. Second positive electrodes are arranged on a lower surface of the second flexible insulating layer at intervals and distributed between the second support structures. The first support structures are offset from the second support structures.

Abstract: A pressure sensor comprises a substrate and a conductive layer disposed on the substrate and a spacer layer having a thickness larger than the thickness of the conductive layer. The pressure sensor also comprises an elastic membrane connected to the spacer layer, which overlays the conductive layer with the spacer layer providing a space therebetween and a sensing electrode layer arranged on a lower surface of the elastic membrane and spaced apart from the conductive layer. The sensing electrode layer forms at least two electrodes opposed and spaced apart from each other. The two electrodes are respectively connected to respective connectors and contact the conductive layer in response to an applied pressure on the elastic membrane. Each electrode transmits an output signal of resistance data to a processor through the respective connector.

Abstract: A pressure sensing device comprises a first diaphragm which is deformable and a second diaphragm which is non-deformable. One of the diaphragms comprises a pressure sensitive material arranged on its surface. The other diaphragm comprises a detection electrode arranged its surface. The first diaphragm forms part of a force transmission device comprising a cavity having a force transmission fluid therein. The force transmission device is configured to receive an external force and transmit the external force to the first diaphragm, such that the first and second diaphragms are mutually deformed in response to the external force.

Abstract: An apparatus for providing a switch mechanism comprises a housing and a pressure sensitive device mounted to the housing. An actuator is moveably connected to the housing to enable the actuator to move along an axis towards and away from the pressure sensitive device. A resilient member has a first end connected to the actuator and a second end connected to the pressure sensitive device.

Abstract: An encrypted photographing method based on fingerprint recognition, and a system thereof are disclosed. The method may include: when detecting starting an encrypted photographing mode, obtaining an unlocking fingerprint for starting the encrypted photographing mode; when detecting a photographing instruction, generating an original photo and generating a key pair based on the unlocking fingerprint wherein the key pair may include an encryption key and a decryption key; encrypting the original photo according to the encryption key so as to generate an encrypted photo; and generating a corresponding system directory according to the decryption key, and saving the encrypted photo to the generated system directory. The present disclosure improves the security of a photo, and avoids leaking the content of an encrypted photo.

Abstract: A double-antenna radio frequency power detection circuit comprises a radio frequency transceiver, a switching module, a first power detection module, a second power detection module, a first antenna, and a second antenna. The switching module outputs a radio frequency signal received from the radio frequency transceiver, to the first power detection module or the second power detection module according to a switching signal. The first power detection module or the second power detection module respectively detects the transmit power of the radio frequency signal passing through the first antenna or the second antenna, and gives a feedback to the radio frequency transceiver.

Abstract: The present invention relates to TrkB binding agonists, and to the use of such agonists in the treatment of neurological disorders and other disorders. The present invention also relates to specific TrkB binding agonists comprising CDRs, variable regions, heavy and light chains, and variant sequences thereof.