Abstract: Provided herein are bilobalide derivative compounds, processes for making, methods of using, and uses thereof for preventing or treating neurological disease and cancer.

Abstract: In an method for detecting a closed loop in MRI: 3D coordinates of key characteristic points of an MRI examination subject are acquired; the 3D coordinates of the key characteristic points are adapted to a 3D body standard model, to obtain a 3D virtual body model of the examination subject; 3D surface regions of pre-designated body parts are extracted from the 3D virtual body model; based on pre-defined body parts where skin contact is likely to occur, a distance between 3D surface regions of two body parts in each body part pair are calculated; and in response to the distance between the 3D surface regions of the two body parts in any body part pair being less than a preset first threshold, a risk of a closed loop in the examination subject is determined.

Abstract: The disclosure provides a manufacturing method for a backflow type irrigation needle tip, and a backflow type irrigation needle tip. In the manufacturing method, a pointed portion of the irrigation needle tip is a closed end. The method includes: setting a laser parameter of the laser apparatus, where the laser parameter includes a repetition frequency, single pulse energy, and a focal spot size; setting a diameter parameter of a laser machining trajectory; adjusting a laser beam for aiming to a designated portion of the irrigation needle tip to be machined, and adjusting a direction of the laser beam and an axial direction of the irrigation needle tip to form an angle, where a range of the angle ? is 10°??<90°; and activating the laser apparatus, and forming an inclined hole towards the closed end on a pipe wall of the irrigation needle tip.

Abstract: A photovoltaic inverter and a temperature detection apparatus. The photovoltaic inverter includes a plurality of photovoltaic terminals, a converter, a printed circuit board (PCB), a temperature detection circuit, and a controller. The plurality of photovoltaic terminals are correspondingly connected to a plurality of photovoltaic modules. The PCB includes an electrically conductive layer and at least one thermally conductive insulation layer. One end of each photovoltaic terminal is soldered on the PCB, and the other end is connected to a corresponding photovoltaic module in a thermally conductive manner. The electrically conductive layer transmits electric energy generated by the plurality of photovoltaic modules to the converter. Each thermally conductive insulation layer conducts heat generated by at least one photovoltaic terminal. The temperature detection circuit detects a temperature of each thermally conductive insulation layer.

Abstract: The disclosure relates to techniques for scan preparation in a medical imaging system. The technique includes triggering a 3D camera acquiring a 2D color and depth image of a patient when a patient bed is at an origin position, inputting the image into a pre-trained first body information model to obtain position information of multiple body feature site points, and calculating position information of multiple candidate scanning regions in the patient bed coordinate system. The technique further includes providing the position information of the multiple candidate scanning regions to a medical imaging application apparatus, so that the medical imaging application apparatus determines position information of a current scanning region in the patient bed coordinate system and controls the patient bed to move the current scanning region to a scanning center of a medical imaging device according to the position of the patient bed relative to the scanning center.

Abstract: A magnetic resonance scanning method including: detecting the positions of individual characteristic points of interest and the positions and sizes of individual sites of interest of a target human body in the current MR scan; calculating a scan start position and a total scan range of the current MR scan according to the detected positions of the individual characteristic points of interest and the positions and sizes of the individual sites of interest of the target human body; and performing the current MR scan according to the calculated scan start position and total scan range of the MR scan. In an aspect, the scanning method is fully automatic.

Abstract: The present disclosure relates to compounds of Formula I: that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.

Abstract: A single groove single-sided fastener comprises: a rivet consisting of a rivet head, a polish rod, a locking groove, a tail pulling groove and a tail tooth in sequence, and a lantern ring consisting of a sleeve and a dead head; a tail of the rivet is of a single groove short-tail structure, a ratio of a length of the tail pulling groove to a total length of the tail tooth is 0.1˜1.5, an included angle between a bottom generatrix of the tail pulling groove and an axis of the rivet is ?30°˜0°, two axial ends of the bottom of the tail pulling groove and the tail of the tail tooth are of a fillet transition structure, a ratio of a length of a straight part of the tail tooth to the total length of the tail tooth is 0.1˜1.

Abstract: Computer software architectures are disclosed that use improved machine learning techniques for data science and data clustering. Computer operations are improved by more efficiently and effectively processing relevant data. Based on a clustering model, initial clusters of taxonomical pairs of entity classifications and entity sub-classifications using taxonomical-level textual data representative of one or more aspects of electronic transactions associated with the taxonomical pairs can be determined, wherein the clustering model has been generated based on machine learning applied to past clusters of past taxonomical pairs of entity classifications and entity sub-classifications other than the initial clusters of the taxonomical pairs, and iteratively refining the initial clusters, according to a similarity criterion, resulting in tuned clusters.

Abstract: The present disclosure relates to a method and system for monitoring on route transportations. The method includes obtaining a driving route of a target vehicle; obtaining a reference position on the driving route away from a first current position of the target vehicle; determining a second current position of the target vehicle after a reference time; determining a distance between the second current position and the reference position is greater than a preset distance; and sending a signal to a target terminal indicating that the target vehicle is off-route.

Abstract: A single groove single-sided fastener comprises: a rivet consisting of a rivet head, a polish rod, a locking groove, a tail pulling groove and a tail tooth in sequence, and a lantern ring consisting of a sleeve and a dead head; a tail of the rivet is of a single groove short-tail structure, a ratio of a length of the tail pulling groove to a total length of the tail tooth is 0.1˜1.5, an included angle between a bottom generatrix of the tail pulling groove and an axis of the rivet is ?30°˜?0°, two axial ends of the bottom of the tail pulling groove and the tail of the tail tooth are of a fillet transition structure, a ratio of a length of a straight part of the tail tooth to the total length of the tail tooth is 0.1˜1.

Abstract: The invention discloses a pulling rivet for fasten-connecting a conductive material. It consists of a rivet and a lantern ring, wherein the rivet comprises a dead head, a polish rod, a locking groove, a pulling groove and a short tail, the lantern ring comprises a flange, a deformation area and a clamping tooth, and a sharp protrusion is arranged on a contact surface of an inner side of the dead head and a fasten-coupling piece. The sharp protrusions of the present invention can be embedded into the surface of the fastening piece to prevent the sliding between the fasten-coupling piece and the rivet, and because the sharp protrusions are embedded into the surface of the fasten-coupling piece to form a tightly fitted whole, which improves the conductivity of the rivet and the frame.

Abstract: Disclosed in embodiments of the present invention are a synchronous control method and system for a laser test of an optical engine. The operation of a laser can be driven by the synchronous control system. When a test of a data point is finished and the optical engine stops for optical window cleaning, the laser may still maintain stable operation under the driving of the synchronous control system, experiments may be directly carried out next time, and thus, laser test efficiency of the optical engine can be improved. Moreover, the synchronous control system is adopted to independently drive the laser to achieve energy stability before experiments, preventing an influence of long-term operation on the performance of the optical engine, and improving test accuracy.

Abstract: An indazole hydrazide compound, as represented in formula (I); wherein, R is selected from substituted alkyl, substituted alkenyl and substituted phenyl; substituent in the substituted alkyl and substituted alkenyl includes phenyl and/or substituted phenyl; R? is selected from H and alkyl. Compared with the prior art, the above indole hydrazide compound can be used as integrin av?3 receptor antagonist. Besides, it has obvious anti-prostate cancer activity and has a significant inhibitory effect on enzalutamide-resistant cell lines. In addition, the above-mentioned compound has obvious anti-tumor angiogenesis activity and can be used in the preparation of anti-tumor angiogenesis drugs to inhibit tumor angiogenesis.

Abstract: A printer head for three-dimensional printing of a continuous fiber-reinforced thermoset composite may include a deposition syringe, a fiber housing, and a feeding tube. The deposition syringe may define a resin reservoir, an air chamber, and a first inlet port configured to deliver a first flow of air to the air chamber. The deposition syringe may include a syringe body and a piston. The syringe body may include an inlet section, a needle section, and a converging section disposed between the inlet section and the needle section. The fiber housing may define a fiber chamber and a second inlet port configured to deliver a second flow of air to the fiber chamber. The feeding tube may extend from the fiber chamber to the needle section and may be configured to receive the second flow of air therein and to guide a fiber from the fiber chamber to the needle section.

Abstract: Disclosed are a mobile Internet-based integrated vehicle energy replenishment system and method, and a storage medium.

Abstract: The present disclosure relates to a method and system for monitoring on route transportations. The method includes obtaining a driving route of a target vehicle; obtaining a reference position on the driving route away from a first current position of the target vehicle; determining a second current position of the target vehicle after a reference time; determining a distance between the second current position and the reference position is greater than a preset distance; and sending a signal to a target terminal indicating that the target vehicle is off-route.

Abstract: Disclosed in embodiments of the present invention are a synchronous control method and system for a laser test of an optical engine. The operation of a laser can be driven by the synchronous control system. When a test of a data point is finished and the optical engine stops for optical window cleaning, the laser may still maintain stable operation under the driving of the synchronous control system, experiments may be directly carried out next time, and thus, laser test efficiency of the optical engine can be improved. Moreover, the synchronous control system is adopted to independently drive the laser to achieve energy stability before experiments, preventing an influence of long-term operation on the performance of the optical engine, and improving test accuracy.

Abstract: The present disclosure relates to compounds that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.