Abstract: A flexible optic fiber sensor film, a mat structure comprising the same and a method of use of the mat structure are provided. The flexible optic fiber sensor film comprises a sandwiched layer and an optic fiber cable arranged in the sandwiched layer; the flexible optic fiber sensor film further comprises protrusions arranged on the sandwiched layer to abut against the optic fiber cable. The flexible optic fiber sensor film is configured for generating light loss in the optic fiber cable when there are body movements of a human subject lying on top of the flexible optic fiber sensor film. The application is safe and comfortable to the human subject.

Abstract: The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent. One particularly preferred method uses methyl chloroformamide in a one-pot reaction at elevated temperatures to provide VNP40101M in high yield.

Abstract: Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Methods of treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy. where R is C1-C10 alkyl or haloalkyl; R? and R? are each independently C1-C10 alkyl; and R1 is C1-C10 alkyl, or a pharmaceutically acceptable salt, solvate, polymorph or metabolite thereof.

Abstract: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring the signal, thereby determining the AGT activity in said sample. This invention provides different uses of this method.

Abstract: Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy. where R is C1-C10 alkyl or haloalkyl; R? and R? are each independently C1-C10 alkyl; R1 is CH3; and X is O; or a pharmaceutically acceptable salt, solvate, polymorph or metabolite thereof.

Abstract: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring the signal, thereby determining the AGT activity in said sample. This invention provides different uses of this method.

Abstract: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring the signal, thereby determining the AGT activity in said sample. This invention provides different uses of this method.

Abstract: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring the signal, thereby determining the AGT activity in said sample. This invention provides different uses of this method.

Abstract: Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formulas I, II, III and IV. Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy.

Abstract: A packet timing method and apparatus for use with a system for controlling digital TV program start time. An encoder inserts a program clock reference (PCR) timing field, in at least two intervals in transport packets. A decoder generates a decoder-clock signal from the PCR timing signal, which has the same frequency as an encoder-clock signal used for encoding. In response to the PCR timing field, a rate of consumption of data is synchronized with a rate of production of data, and chroma sub-carrier is synchronized.

Abstract: A conditional access method and apparatus for use with a system for controlling of digital TV program start time. Subscriber access is authorized to digital program streams. Content are divided into a plurality of working periods. Each working period of the plurality of working periods is scrambled with a different working key. A working key of a given period is delivered ahead of the given period. The working key is synchronized with scrambling control bits in an header working keys are inserted into an entitlement control message (ECM) packet, and the ECM packet is encrypted using a service key. A time period is inserted into the ECM packet during which the service key is valid. A service key is inserted in an entitlement.

Abstract: A method of an input unit of a method and apparatus for controlling digital TV program start time. The input unit and method of the input unit receive digital channels from multiple sources, as a plurality of digital-transport streams, respectively. Each digital-transport stream has a multiplicity of transport packets. The input unit and method time-stamp each of the received transport packets of the multiplicity of transport packets, thereby generating a plurality of time-stamped packets, and aggregate the plurality of time-stamped packets, and scramble the aggregated plurality of time-stamped packets. The scrambled-aggregated plurality of time-stamped packets are encapsulated.

Abstract: A video system for providing a large number of video streams. The video system includes a video server and dividing means. Storage means, a switch and control means are located at the video server. The video server has a plurality of central-processing units (CPUs). The dividing means divides a plurality of input video-streams entering the video system, and sends the divided plurality of input-video streams, with each divided video stream identified with a separate Ethernet address, to the video server. The storage means stores an input video-stream of the plurality of input video-streams as a stored-video stream. The switch routes an input-video stream of the plurality of input-video streams to the storage means. The control means controls the storage means to replay the stored-video stream and to control portions of the stored-video stream at an appropriate time, and controls the plurality of CPUs at the video server to work in parallel.

Abstract: The present invention relates to compounds according to the structure (I): Where R is —CH3 or —CH2CH2Cl; R? is C1-C7 alkyl or —CH2CH2Cl; R2 or R4 is OP03H2, N02, OCO(Glu-OH), NHCO(Glu-OH), NHR7 and unassigned groups of R2, R3, R4, R5 and R6 are, independently, H, F, Cl, Br, I, OH, OP03H2, OCH3, CF3, OCF3, NO2, CN, SO2CH3, SO2CF3, COCH3, COOCH3, SCH3, SFs, NH2, NHR7, N(CH3)2, OPO3H2, or a C1-C7 alkyl group with the proviso that when any two of unassigned groups of R2, R3, R4, R5 or R6 are other than H, the other two of unassigned groups of R2, R3, R4, R5 or R6 are H. R7 is H or polyglutamyl as described. Phosphoric acid and glutamic acid can be a free acid or pharmaceutically acceptable salt thereof.

Abstract: A construction arrangement for a small set-top box to protect cryptographic capabilities and prevent a digital program in clear from being able to be tapped as required by Digital Rights Management protocols. A first layer of sheet metal capable of blocking X-rays, is formed as a shallow pan to hold a set of printed circuit boards. A second layer has a thin epoxy based printed circuit material. A third layer has a printed circuit board with integrated components placed on top of the second layer. A fourth layer has a three layer thin printed circuit board with a first and second metallic layer and holes for large components, such as electrolytic capacitors. A black liquid thermosetting epoxy fills the interstices between the sheet metal layer and the second layer, and between the second layer and the third layer, and between the third layer and the fourth layer, thereby preventing access to exposed circuit trace carrying digital signals in the clear.

Abstract: The present invention relates to compounds according to the structure (I): Where R is —CH3 or —CH2CH2Cl; R? is C1-C7 alkyl or —CH2CH2Cl; R2 or R4 is OPO3H2, NO2, OCO(Glu-OH), NHCO(Glu-OH), NHR7 and unassigned groups of R2, R3, R4, R5 and R6 are, independently H, F, Cl, Br, I, OH, OPO3H2, OCH3, CF3, OCF3, NO2, CN, SO2CH3, SO2CF3, COCH3, COOCH3, SCH3, SF5, NH2, NHR7, N(CH3)2, OPO3H2, or a C1-C7 alkyl group with the proviso that when any two of unassigned groups of R2, R3, R4, R5 or R6 are other than H, the other two of unassigned groups of R2, R3, R4, R5 or R6 are H. R7 is H or polyglutamyl as described. Phosphoric acid and glutamic acid can be a free acid or pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds according to the structure (I): 1

Abstract: The invention provides methods to assay and regulate the replication of hepatitis B virus (HBV), employing methods of generating HBV replication mutants. Based on the polymerase gene of HBV strains, various primers were designed, and by using restriction enzymes and polymerase chain reaction, fragments of the polymerase gene were substituted, and the replicative competency of the newly constructed recombinant polymerase gene was analyzed. This invention can be used to look for new functional domains in the polymerase and for designing anti-HBV replicating drugs and diagnostic reagents.

Abstract: The present invention relates to compounds according to the structure: Where R is H or CH3; R2 is phosphate which can be free acid or salt; R3 is H, F, Cl, Br, I, OCH3, OCF3 , CF3 or a C1-C3 alkyl group; R4 is H, F, Cl, Br, I, OCH3, OCF3 or CF3; and R5 and R6 are each independently H, F, Cl, Br, I, OCH3, OCF3 or CF3, with the proviso that when any two of R3, R4, R5 or R6 are other than H, the other two of R3, R4, R5 or R6 are H which may be used to treat neoplasia, including cancer.

Abstract: The present invention relates to compounds according to the structure: 1