Abstract: Broadly applicable and stereoselective formation of glycosidic linkage remains challenging yet of critical importance in giycoscience. By developing an SN2 glycosylation, this work advances a general solution to this challenge via stereoinversion at the anomeric position of glycosyl ester donors. This SN2 process is enabled by a basic directing-group in the leaving-group, which is activated by a cationic gold catalyst or any other electrophilic reagent. Unlike all the reported directing group approaches, this strategy is applicable to any glycosyl donors—a long sought-after yet unmet goal in carbohydrate chemistry; moreover, the basic directing-group upon glycosylation is lost as part of the leaving-group and hence traceless in the glycoside products, therefore avoiding potential complications in downstream transformations. Highly selective construction of glycosidic bonds including challenging 1,2-cis glycosidic bonds is achieved in excellent yields.

Abstract: In a tower integrated by the heating and drying section and the cooling section, both sides of the heating and drying section housing are provided with an air inlet box and an air outlet box; the air inlet box is communicating with a heat exchanger and distribution pipes in the heating and drying section housing, the air outlet box is communicating with distribution pipes in the heating and drying section housing and a dust remover; both sides of the cooling section housing are provided with an air inlet box and an air outlet box; the air inlet box is communicating with a heat exchanger and distribution pipes in the cooling section housing; the air outlet box is communicating with distribution pipes in the cooling section housing and a dust remover. The integral device improves the heat exchange effect and preventing the polypropylene particles from aging.

Abstract: A drill bit for cutting formation comprises a bit body, a plurality of cutters, and a plurality of blades with pockets to accommodate the cutters, respectively. Each of the plurality of cutters has a substrate, an ultra-hard layer, an inclined surface on the top of the ultra-hard layer, wherein the inclined surface slants downward from a cutting edge to a trailing edge. The cutter can improve cutting efficiency and service life.

Abstract: A fly ash-based fire-prevention and extinguishing material with carbon dioxide mineralized and stored, and a preparation method thereof are provided. The preparation method includes: separately weighing 100 parts to 120 parts of water, 1 part to 3 parts of a solid strong alkali, and 20 parts to 40 parts of a fly ash as raw materials, pouring the raw materials into a reactor successively to obtain a resulting mixture, and stirring the resulting mixture at a high rotational speed; adding 10 parts to 20 parts of a solubilizing agent to the reactor, sealing the reactor, introducing carbon dioxide to the reactor at room temperature to maintain a carbon dioxide pressure to obtain a resulting slurry, and stirring the resulting slurry at a high rotational speed; and further introducing carbon dioxide into the reactor to increase the carbon dioxide pressure, and stirring the resulting slurry at a low rotational speed.

Abstract: A carrier device in semiconductor processing equipment includes a base and an edge ring. The base includes a base body configured to carry a wafer and has an outer diameter smaller than a diameter of the wafer. The edge ring surrounds the base and has an outer diameter greater than the diameter of the wafer. An outer circumferential surface of the base body faces and is spaced from an inner circumferential surface of the edge ring to form a first annular channel. The first annular channel communicates with a gas supply system. When the base body carries the wafer, an upper surface of the edge ring faces and is spaced from a lower surface of the wafer to form a second annular channel. The first annular channel communicates with the second annular channel.

Abstract: The present invention proposes an in-situ freezing machining method for an integrated thin-walled array structure. In the method, the area among cups is cut off first; then, the outer walls of a cup array are machined; and finally, water filling and freezing are carried out, and in-situ freezing machining of the inner walls of the cup array is carried out. Then, hoisting and turning over are carried out, and the area among cavities is cut off; then, the outer walls of a cavity array are machined; and finally, water filling and freezing are carried out, and in-situ freezing machining of the inner walls of the cavity array is carried out. The method realizes in-situ freezing clamping of workpieces, avoids error accumulation caused by repeated installation of a fixture, and can refrigerate efficiently, suppress ambient and cutting thermal interference, and ensure the stability of freezing fixture.

Abstract: An electronic device may be provided with peripheral conductive housing structures, a first antenna, and a second antenna. A gap may divide the housing structures into a first segment forming an arm of the first antenna and a second segment forming an arm of the second antenna. A first feed terminal may be coupled to the first segment and a second feed terminal may be coupled to the second segment. Switchable components may be coupled in parallel between the first and second feed terminals across the gap. The switchable components may be adjusted to tune the frequency response of the first and/or second antenna. The switchable components may have a first state in which only the first feed terminal feeds the first antenna and may have a second state in which both the first and second feed terminals feed the first antenna.

Abstract: An electronic device may be provided with an antenna having a resonating element and a light source module mounted to a flexible printed circuit and a metal cowling. The module may emit light through a rear housing wall. The printed circuit may be interposed between the metal cowling and a conductive support plate in the rear housing wall. The printed circuit may include a ground trace coupled to the resonating element. A dimpled pad may couple the ground trace to the support plate. Compressive foam may be used to exert a force against the flexible printed circuit that presses the dimpled pad against the conductive support plate. The ground trace and the dimpled pad may form a return path to ground for the resonating element. The dimpled pad may occupy less height within the device than other structures such as metal springs.

Abstract: Disclosed are a PAM restriction-free adenine base editor fused protein and use. A mutant polypeptide is provided, which comprises an N-terminal fragment of SpRY(D10A), a TadA8e fragment, and a C-terminal fragment of SpRY(D10A) polypeptide in sequence from the N terminus to the C terminus. A fused protein including the mutant polypeptide can target the whole genome, thereby broadening the editable range of the genome. It can induce a base transition of A:T to G:C more efficiently, and has great use potential, including but not limited to, simulation or correction of pathogenic sites in genetic disorders. It lowers off-target at the transcriptome level, and is a mutant form with high efficiency and low off-target.

Abstract: A method and apparatus for managing buffering of data packets of a network card, a terminal and a storage medium are provided. The method includes: setting ring buffer queues, setting a length of each ring buffer queue, then setting a buffer pool formed by two ring buffer queues, and setting the two ring buffer queues in the buffer pool as a busy queue and an idle queue, respectively; a network card driver receiving data packets from a data link, classifying the data packets, sequentially buffering the classified data packets into the busy queue, and then sequentially mapping addresses of the buffered data packets in the busy queue into the idle queue; acquiring latest addresses of the buffered data packets in the busy queue; and the upper-layer application successively acquiring and processing the buffered data packets, and successively releasing the addresses of the processed buffered data packets in the busy queue.

Abstract: A method and apparatus for managing buffering of data packets of a network card, a terminal and a storage medium are provided.

Abstract: The present invention relates to a vaginal sustained-release drug delivery system for luteal support and a method for preparation and use thereof. The vaginal sustained-release drug delivery system for luteal support is a progesterone depot-type vaginal ring having a bilayer structure of a core layer and a film layer enclosing the core layer, wherein the core layer is composed of a solid scaffold carrier of medical EVA containing a drug uniformly dispersed therein, and the film layer is composed of a medical EVA material containing no drug. The vaginal sustained-release drug delivery system for luteal support according to the present invention can be used for assisted reproduction and for treatment of functional uterine bleeding, premenstrual syndrome and the like due to luteal phase defect with a significantly improved therapeutic effect.

Abstract: The present invention discloses a method for lowering an oil pipe in a gas well without well-killing, a soluble bridge plug and a material preparation method thereof, wherein, the method comprises the steps of: lowering a bridge plug in a wellbore such that the bridge plug blocks the wellbore at a predetermined location in the wellbore; injecting water in the wellbore after the pressure in the wellbore has been relieved so as to replace gases in the wellbore; and lowering an oil pipe in the wellbore to the location of the bridge plug. The method for lowering an oil pipe in a gas well without well-killing, the soluble bridge plug and the material preparation method thereof provided in the present invention successfully solve the problem of high cost for lowering an oil pipe under pressure after a fracturing fluid has been injected into the casing.

Abstract: The present invention relates to a vaginal sustained-release drug delivery system for luteal support and a method for preparation and use thereof. The vaginal sustained-release drug delivery system for luteal support is a progesterone depot-type vaginal ring having a bilayer structure of a core layer and a film layer enclosing the core layer, wherein the core layer is composed of a solid scaffold carrier of medical EVA containing a drug uniformly dispersed therein, and the film layer is composed of a medical EVA material containing no drug. The vaginal sustained-release drug delivery system for luteal support according to the present invention can be used for assisted reproduction and for treatment of functional uterine bleeding, premenstrual syndrome and the like due to luteal phase defect with a significantly improved therapeutic effect.

Abstract: The present invention discloses a method for lowering an oil pipe in a gas well without well-killing, a soluble bridge plug and a material preparation method thereof, wherein, the method comprises the steps of: lowering a bridge plug in a wellbore such that the bridge plug blocks the wellbore at a predetermined location in the wellbore; injecting water in the wellbore after the pressure in the wellbore has been relieved so as to replace gases in the wellbore; and lowering an oil pipe in the wellbore to the location of the bridge plug. The method for lowering an oil pipe in a gas well without well-killing, the soluble bridge plug and the material preparation method thereof provided in the present invention successfully solve the problem of high cost for lowering an oil pipe under pressure after a fracturing fluid has been injected into the casing.

Abstract: A method of manufacturing a semiconductor device is disclosed, which can completely remove hard mask residues left along boundaries between a high-voltage device region and STI structures after a dry etch process, by partially reducing a thickness of each of the exposed portion of the respective STI structures adjacent to the high-voltage device region so as to sufficiently expose the residues. As a result, after a portion of an underlying pad oxide corresponding to the high-voltage device region is removed in a subsequent process, the exposed surface of the substrate is uniform with a smooth and clear border. Therefore, no sharp corners will emerge at a border of a gate oxide subsequently grown on the exposed surface of the substrate, and the gate oxide is thus morphologically improved, thereby resulting in an improvement of the reliability of the high-voltage semiconductor device being fabricated.

Abstract: A method for analyzing circuit pattern is disclosed. The method includes the steps of: providing a plurality of monitor metal line structures formed on discrete locations of a substrate corresponding to different values of variable factors; performing a defect review to identify failure locations of the monitor metal line structures; determining a failure tendency of the monitor metal line structures so as to determine a boundary of the variable factors; and determining whether adjustment is to be made to product metal line structures.

Abstract: A method of manufacturing a semiconductor device is disclosed, which can completely remove hard mask residues left along boundaries between a high-voltage device region and STI structures after a dry etch process, by partially reducing a thickness of each of the exposed portion of the respective STI structures adjacent to the high-voltage device region so as to sufficiently expose the residues. As a result, after a portion of an Underlying pad oxide corresponding to the high-voltage device region is removed in a subsequent process, the exposed surface of the substrate is uniform with a smooth and clear border. Therefore, no sharp corners will emerge at a border of a gate oxide subsequently grown on the exposed surface of the substrate, and the gate oxide is thus morphologically improved, thereby resulting in an improvement of the reliability of the high-voltage semiconductor device being fabricated.

Abstract: A test pattern structure including a first conductive layer and a second conductive layer is provided. The second conductive layer is directly disposed on the first conductive layer and connected to the first conductive layer through a plurality of connection interfaces. The test pattern structure of the present invention can detect the interconnection failure quickly and correctly without SEM identification.